{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:15:32Z","timestamp":1788358532143,"version":"build-2803163510"},"reference-count":40,"publisher":"The Royal Society","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/-\/media\/journals\/author\/Licence-to-Publish-20062019-final.pdf"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"L'Oreal-UNESCO Fellowship for Women in Science"},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Biol. Lett."],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    In most mammals, running is fuelled by oxidization of endogenous carbohydrates and lipids while amino acids contribute little (&lt;\u20095\u201310%). Common vampire bats (\n                    <jats:italic>Desmodus rotundus<\/jats:italic>\n                    ), however, specialize on a unique, protein-rich blood diet. Therefore, we hypothesized that (i) vampire bats would rapidly begin utilizing dietary amino acids to support running metabolism, and (ii) that relative reliance on essential and non-essential amino acids would be similar. We fed bats cow\u2019s blood enriched either with isotopically labelled glycine (non-essential amino acid) or leucine (essential amino acid). Bats were exercised at speeds of 10, 20 and 30 m\u2009min\n                    <jats:sup>\u22121<\/jats:sup>\n                    on a respirometry treadmill, allowing us to assess metabolic rate (i.e. O\n                    <jats:sub>2<\/jats:sub>\n                    consumption and CO\n                    <jats:sub>2<\/jats:sub>\n                    production) and track the oxidation of labelled amino acids in exhaled CO\n                    <jats:sub>2<\/jats:sub>\n                    . Vampire bats oxidized amino acids as their primary fuel as indicated by a respiratory exchange ratio (RER = ratio of CO\n                    <jats:sub>2<\/jats:sub>\n                    production to O\n                    <jats:sub>2<\/jats:sub>\n                    consumption rates) of approximately 0.8\u20130.9 at all speeds, with the labelled meal accounting for as much as 60% of oxidized fuels at peak usage. Similar oxidation rates indicated bats did not discriminate between essential and non-essential amino acid use. These findings reiterate how strongly metabolism can be shaped by a specialized diet.\n                  <\/jats:p>","DOI":"10.1098\/rsbl.2024.0453","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T19:05:27Z","timestamp":1730833527000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Vampire bats rapidly fuel running with essential or non-essential amino acids from a blood meal"],"prefix":"10.1098","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4812-8869","authenticated-orcid":true,"given":"Giulia S.","family":"Rossi","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Toronto, Scarborough, Ontario M1C 1A4, Canada"},{"name":"Department of Biology, McMaster University, Hamilton, Ontario L8S 4E8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-6510","authenticated-orcid":true,"suffix":"Jr","given":"Kenneth C.","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Toronto, Scarborough, Ontario M1C 1A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.6.2253"},{"key":"e_1_3_7_3_2","first-page":"17","volume-title":"Progress in molecular biology and translational science","author":"Mul JD","unstructured":"Mul JD, Stanford KI, Hirshman MF, Goodyear LJ. 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