{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T01:33:40Z","timestamp":1772156020311,"version":"3.50.1"},"reference-count":55,"publisher":"The Royal Society","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/-\/media\/journals\/author\/Licence-to-Publish-20062019-final.pdf"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/100000076","name":"Directorate for Biological Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Biol. Lett."],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    Variation in ambient temperature and food availability is commonplace in nature and likely exerts several types of eco-evolutionary pressures that mediate species\u2019 interactions. In predator\u2013prey interactions between snakes and rodents, the molecular interface is formed by snake venom and mammalian venom resistance proteins. However, the abiotic factors modulating resistance are poorly understood. Here, we measured serum-based venom resistance of desert woodrats (\n                    <jats:italic>Neotoma lepida<\/jats:italic>\n                    ) maintained at either cool or warm ambient temperatures and fed creosote bush resin (native diet) or a control diet. Woodrat serum was collected and tested for its ability to inhibit the activity of rattlesnake venom metalloproteinases. Woodrats raised at cooler temperatures, as well as those consuming diets with creosote resin, were significantly less able to inhibit snake venom, suggesting that they would be more susceptible to snakebite. These results suggest that temperature and dietary variation across the distribution over which these rattlesnakes and woodrats interact could structure the outcomes of these predator\u2013prey interactions. Additionally, these results may help explain why ambient temperatures, rather than dietary differences, predict the presence of neurotoxic versus proteolytic venom phenotypes in some rattlesnake species.\n                  <\/jats:p>","DOI":"10.1098\/rsbl.2025.0068","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T19:05:22Z","timestamp":1744743922000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ambient temperature and toxic diets constrain snake venom resistance in a desert rodent"],"prefix":"10.1098","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-3012","authenticated-orcid":true,"given":"Matthew L.","family":"Holding","sequence":"first","affiliation":[{"name":"Life Sciences Institute, University of Michigan","place":["Ann Arbor, USA"]},{"name":"Department of Ecology and Evolutionary Biology, University of Michigan","place":["Ann Arbor, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0451-3690","authenticated-orcid":true,"given":"Alexandra","family":"Coconis","sequence":"additional","affiliation":[{"name":"Program in Ecology, Evolution, and Conservation Biology, Department of Natural Resources and Environmental Science, University of Nevada Reno","place":["Reno, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-1585","authenticated-orcid":true,"given":"Patrice K.","family":"Connors","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Utah","place":["Salt Lake City, USA"]},{"name":"Department of Biological Sciences, Colorada Mesa University","place":["Grand Junction, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-3749","authenticated-orcid":true,"given":"Marjorie D.","family":"Matocq","sequence":"additional","affiliation":[{"name":"Program in Ecology, Evolution, and Conservation Biology, Department of Natural Resources and Environmental Science, University of Nevada Reno","place":["Reno, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-4934","authenticated-orcid":true,"given":"M. Denise","family":"Dearing","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Utah","place":["Salt Lake City, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2015.2387"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2022.888550"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/588490"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2013.0562"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2013.07.007"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1979.237.6.H705"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-012-0670-y"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/mec.14192"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001414"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2015579118"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.2307\/2421524"},{"key":"e_1_3_8_13_2","first-page":"228","volume-title":"Biology of the rattlesnakes II","author":"Gren E","year":"2017","unstructured":"Gren E, Kelln W, Person C. 2017 Geographic variation of venom composition and neurotoxicity in the rattlesnakes Crotalus oreganus and C. helleri: assessing the potential roles of selection and neutral evolutionary processes in shaping venom variation. In Biology of the rattlesnakes II (eds MJ Dreslik, WK Hayes, SJ Beaupre, SP Mackessy), pp. 228\u2013252. Rodeo, NM: Eco Herpetological Publishing and Distribution."},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35810-9"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2018.2735"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/jeb.13347"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2015.2841"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1644\/08-MAMM-A-261.1"},{"key":"e_1_3_8_19_2","article-title":"The desert woodrat (Neotoma lepida) induces a diversity of biotransformation genes in response to creosote bush resin","volume":"280","author":"Greenhalgh R","year":"2024","unstructured":"Greenhalgh R, Klure DM, Orr TJ, Armstrong NM, Shapiro MD, Dearing MD. 2024 The desert woodrat (Neotoma lepida) induces a diversity of biotransformation genes in response to creosote bush resin. Comp. Biochem. Physiol. C 280, 109870. 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In Biology of the rattlesnakes (eds WK Hayes, KR Beaman, MD Cardwell, SP Bush), pp. 557\u2013568. Loma Linda, CA: Loma Linda University Press."},{"key":"e_1_3_8_25_2","first-page":"495","volume-title":"Biology of the rattlesnakes","author":"Mackessy SP","year":"2008","unstructured":"Mackessy SP. 2008 Venom composition in rattlesnakes: trends and biological significance. In Biology of the rattlesnakes (eds WK Hayes, KR Beaman, MD Cardwell, SP Bush), pp. 495\u2013510. 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