{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:03:08Z","timestamp":1789020188407,"version":"build-2803163510"},"reference-count":57,"publisher":"The Royal Society","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wilson Family Trust"},{"name":"Revive & Restore Wild Genomes"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Biol. Lett."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Pigmentation in mammalian hair follicles is governed in part by interactions between agouti signalling protein (ASIP) and the melanocortin 1 receptor (MC1R). The most common coat colours in mammals result from alternating bands of dark eumelanin and light phaeomelanin within individual hair shafts. However, coats dominated by a single melanin have arisen several times. Here, we examine the genetic basis of two instances in marsupials: a melanistic morph of the eastern quoll (\n                    <jats:italic toggle=\"yes\">Dasyurus viverrinus<\/jats:italic>\n                    ) found at high frequency in the wild, and a rare case of fixed xanthism in the marsupial moles. In eastern quolls, we identify a deletion encompassing the\n                    <jats:italic toggle=\"yes\">ASIP<\/jats:italic>\n                    start codon which was found to be homozygous only in the melanistic animals examined. This mutation appears to be convergent with that recently discovered in its dark-coated relative, the Tasmanian devil (\n                    <jats:italic toggle=\"yes\">Sarcophilus harrisii<\/jats:italic>\n                    ). Conversely, we show that a non-sense mutation which severely truncates\n                    <jats:italic toggle=\"yes\">MC1R<\/jats:italic>\n                    in the southern marsupial mole (\n                    <jats:italic toggle=\"yes\">Notoryctes typhlops<\/jats:italic>\n                    ) is a candidate driver of its pale-yellow coat. Together with other recent findings, our results suggest that loss-of-function mutations have occurred repeatedly within the marsupials, representing a mechanism underpinning coat colour variation.\n                  <\/jats:p>","DOI":"10.1098\/rsbl.2025.0302","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:05:32Z","timestamp":1761087932000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Loss-of-function mutations in\n                    <i>ASIP<\/i>\n                    and\n                    <i>MC1R<\/i>\n                    are associated with coat colour variation in marsupials"],"prefix":"10.1098","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1754-8207","authenticated-orcid":true,"given":"Ryan","family":"Sauermann","sequence":"first","affiliation":[{"name":"School of BioSciences, The University of Melbourne","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-1530","authenticated-orcid":true,"given":"Bronwyn","family":"Fancourt","sequence":"additional","affiliation":[{"name":"School of Environmental and Rural Science, University of New England","place":["Armidale, Australia"]},{"name":"Department of the Environment, Tourism, Science & Innovation, Queensland Parks and Wildlife Service","place":["Toowoomba, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Australian Reptile Park & Aussie Ark","place":["Somersby, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Shute","sequence":"additional","affiliation":[{"name":"Australian Reptile Park & Aussie Ark","place":["Somersby, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Reid","sequence":"additional","affiliation":[{"name":"Australian Reptile Park & Aussie Ark","place":["Somersby, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1900-2263","authenticated-orcid":true,"given":"Andrew J.","family":"Pask","sequence":"additional","affiliation":[{"name":"School of BioSciences, The University of Melbourne","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-5254","authenticated-orcid":true,"given":"Charles Yakov","family":"Feigin","sequence":"additional","affiliation":[{"name":"School of Agriculture, Biomedicine and Environment, La Trobe University","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.05.032"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12292572"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-023-02213-7"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00128-3"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006435"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12862-019-1471-7"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0431157100"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2052.2008.01712.x"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.3897\/neotropical.19.e125890"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1515\/mammalia-2023-0104"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010005"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/age.12660"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ani14233354"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06251-0"},{"key":"e_1_3_8_16_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1644\/1545-1410(2001)677<0001:DV>2.0.CO;2","article-title":"Dasyurus viverrinus","author":"Jones ME","year":"2001","unstructured":"Jones ME, Rose RK. 2001 Dasyurus viverrinus. Mamm. Species 1\u20139. (doi:10.2307\/0.677.1)","journal-title":"Mamm. Species"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-384719-5.00089-7"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado4140"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10914-013-9236-3"},{"key":"e_1_3_8_20_2","first-page":"70","article-title":"The animal life of the Sunbury district sixty years ago","volume":"24","author":"Batey I","year":"1907","unstructured":"Batey I. 1907 The animal life of the Sunbury district sixty years ago. Vic. Nat. 24, 70\u201371.","journal-title":"Vic. Nat."},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.2307\/1374524"},{"key":"e_1_3_8_22_2","unstructured":"Fancourt B. 2010 Spatial and temporal variation in declining eastern quoll (Dasyurus viverrinus) populations in Tasmania. PhD thesis. University of Tasmania Hobart Tasmania."},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu176"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1071\/AM75007"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00095"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1010"},{"key":"e_1_3_8_28_2","article-title":"Genome of the endangered eastern quoll (Dasyurus viverrinus) reveals signatures of historical decline and pelage color evolution","author":"Hartley GA","year":"2023","unstructured":"Hartley GA et al. 2023 Genome of the endangered eastern quoll (Dasyurus viverrinus) reveals signatures of historical decline and pelage color evolution. bioRxiv 2023.2009.2006.556354. 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