{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:31:06Z","timestamp":1762032666210},"reference-count":0,"publisher":"The Royal Society","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biogr. Mems Fell. R. Soc."],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>\n            Julie Axelrod was a laboratory technician until the age of 42 years, when he finally achieved his PhD and independence. He worked at the National Institutes of Health for most of his career. Among his early pioneering research achievements in applying chemical and biochemical approaches to neuroscience were the discoveries of the painkiller acetaminophen (Tylenol, Paracetamol) and the liver microsomal drug\u2013metabolizing enzymes, and the establishment of catechol\u2013\n            <jats:italic>O<\/jats:italic>\n            \u2013methyltransferase as an important enzyme in catecholamine metabolism. He shared the Nobel Prize in Physiology or Medicine in 1970 for his discovery that the reuptake of noradrenaline (norepinephrine) into the nerve endings from which it was released represented a novel method of neurotransmitter inactivation. An important corollary was the finding that antidepressant drugs acted as inhibitors of this uptake process.\n          <\/jats:p>","DOI":"10.1098\/rsbm.2006.0002","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T04:03:17Z","timestamp":1181793797000},"page":"1-13","source":"Crossref","is-referenced-by-count":2,"title":["Julius Axelrod. 30 May 1912 \u2014 29 December 2004"],"prefix":"10.1098","volume":"52","author":[{"given":"Leslie","family":"Iversen","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of OxfordMansfield Road, Oxford OX1 3QTUK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2006,12]]},"container-title":["Biographical Memoirs of Fellows of the Royal Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsbm.2006.0002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsbm.2006.0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T08:52:37Z","timestamp":1613724757000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsbm.2006.0002"}},"subtitle":["Elected ForMemRS 1979"],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":0,"alternative-id":["10.1098\/rsbm.2006.0002"],"URL":"https:\/\/doi.org\/10.1098\/rsbm.2006.0002","relation":{},"ISSN":["0080-4606","1748-8494"],"issn-type":[{"value":"0080-4606","type":"print"},{"value":"1748-8494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}