{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:14:16Z","timestamp":1789730056513,"version":"4.0.1"},"reference-count":57,"publisher":"The Royal Society","issue":"3","license":[{"start":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T00:00:00Z","timestamp":1302048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cerebral aneurysms are a multi-factorial disease with severe consequences. A core part of the European project @neurIST was the physical characterization of aneurysms to find candidate risk factors associated with aneurysm rupture. The project investigated measures based on morphological, haemodynamic and aneurysm wall structure analyses for more than 300 cases of ruptured and unruptured aneurysms, extracting descriptors suitable for statistical studies. This paper deals with the unique challenges associated with this task, and the implemented solutions. The consistency of results required by the subsequent statistical analyses, given the heterogeneous image data sources and multiple human operators, was met by a highly automated toolchain combined with training. A testimonial of the successful automation is the positive evaluation of the toolchain by over 260 clinicians during various hands-on workshops. The specification of the analyses required thorough investigations of modelling and processing choices, discussed in a detailed analysis protocol. Finally, an abstract data model governing the management of the simulation-related data provides a framework for data provenance and supports future use of data and toolchain. This is achieved by enabling the easy modification of the modelling approaches and solution details through abstract problem descriptions, removing the need of repetition of manual processing work.<\/jats:p>","DOI":"10.1098\/rsfs.2010.0033","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T12:47:50Z","timestamp":1310474870000},"page":"308-319","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["@neurIST complex information processing toolchain for the integrated management of cerebral aneurysms"],"prefix":"10.1098","volume":"1","author":[{"given":"M. C.","family":"Villa-Uriol","sequence":"first","affiliation":[{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), c\/ Tanger 122\u2013140, E08018 Barcelona, Spain 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Berti","sequence":"additional","affiliation":[{"name":"Consulting in mathematical methods, Bonn, Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Hose","sequence":"additional","affiliation":[{"name":"Medical Physics Group, Faculty of Medicine, University of Sheffield, Sheffield, UK 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Marzo","sequence":"additional","affiliation":[{"name":"Medical Physics Group, Faculty of Medicine, University of Sheffield, Sheffield, UK 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chiarini","sequence":"additional","affiliation":[{"name":"BioComputing Competence Centre SCS s.r.l., Casalecchio di Reno, Italy 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Penrose","sequence":"additional","affiliation":[{"name":"ANSYS UK, Ltd, Abingdon, UK 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pozo","sequence":"additional","affiliation":[{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), c\/ Tanger 122\u2013140, E08018 Barcelona, Spain 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"University of Applied Science Koblenz, Germany 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Medical Physics Group, Faculty of Medicine, University of Sheffield, Sheffield, UK 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lycett","sequence":"additional","affiliation":[{"name":"Medical Physics Group, Faculty of Medicine, University of Sheffield, Sheffield, UK 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Larrabide","sequence":"additional","affiliation":[{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), c\/ Tanger 122\u2013140, E08018 Barcelona, Spain 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Frangi","sequence":"additional","affiliation":[{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), c\/ Tanger 122\u2013140, E08018 Barcelona, Spain 2"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), c\/ Tanger 122\u2013140, E08018 Barcelona, Spain 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2011,4,6]]},"reference":[{"key":"2026022414450184800_RSFS20100033C1","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1056\/NEJMra052760","article-title":"Medical progress: cerebral aneurysms","volume":"355","author":"Brisman,","year":"2006","journal-title":"New Engl. J. Med."},{"key":"2026022414450184800_RSFS20100033C2","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/S0140-6736(02)11314-6","article-title":"International subarachnoid aneurysm trial (ISAT) of neurological clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial","volume":"360","author":"Molyneux,","year":"2002","journal-title":"Lancet"},{"key":"2026022414450184800_RSFS20100033C3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","article-title":"Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment","volume":"362","author":"Wiebers,","year":"2003","journal-title":"Lancet"},{"key":"2026022414450184800_RSFS20100033C4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00424-002-0890-1","article-title":"The IUPS human physiome project","volume":"445","author":"Hunter,","year":"2002","journal-title":"Eur. J. Physiol."},{"key":"2026022414450184800_RSFS20100033C5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nrm1017","article-title":"Integration from proteins to organs: the physiome project","volume":"4","author":"Hunter,","year":"2003","journal-title":"Nature"},{"key":"2026022414450184800_RSFS20100033C6","article-title":"Seeding the EuroPhysiome: a roadmap to the virtual physiological human. See","author":"STEP Consortium","year":"2007"},{"key":"2026022414450184800_RSFS20100033C7","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1098\/rsta.2008.0089","article-title":"The EuroPhysiome, STEP and a roadmap for the virtual physiological human","volume":"366","author":"Fenner,","year":"2008","journal-title":"Proc. R. Soc. A"},{"key":"2026022414450184800_RSFS20100033C8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.2170\/physiolsci.RP009908","article-title":"The virtual physiological human\u2014a European initiative for in silico human modelling","volume":"58","author":"Viceconti,","year":"2008","journal-title":"J. Physiol. Sci."},{"key":"2026022414450184800_RSFS20100033C9","first-page":"161","article-title":"The @neurIST project","volume":"138","author":"Iavindrasana,","year":"2008","journal-title":"Stud. Health Technol. Inform."},{"key":"2026022414450184800_RSFS20100033C10","first-page":"173","article-title":"@neurIST\u2014chronic disease management through integration of heterogeneous data and computer-interpretable guideline services","volume":"138","author":"Dunlop,","year":"2008","journal-title":"Stud. Health Technol. Inform."},{"key":"2026022414450184800_RSFS20100033C11","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1109\/TNB.2007.897438","article-title":"A service-oriented grid infrastructure for biomedical data and compute services","volume":"6","author":"Arbona,","year":"2007","journal-title":"IEEE Trans. Nanobiosci."},{"key":"2026022414450184800_RSFS20100033C12","first-page":"165","article-title":"@neuLink: a service-oriented application for biomedical knowledge discovery","volume":"138","author":"Friedrich,","year":"2008","journal-title":"Stud. Health Technol. Inform."},{"key":"2026022414450184800_RSFS20100033C13","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1098\/rsta.2008.0099","article-title":"Knowledge environments representing molecular entities for the virtual physiological human","volume":"366","author":"Hofmann-Apitius,","year":"2008","journal-title":"Phil. Trans. R. Soc. A"},{"key":"2026022414450184800_RSFS20100033C14","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1109\/TITB.2010.2049268","article-title":"@neurist\u2014infrastructure for advanced disease management through integration of heterogeneous data, computing, and complex processing services","volume":"14","author":"Benkner,","year":"2010","journal-title":"IEEE Trans. Info. Technol. BioMed."},{"key":"2026022414450184800_RSFS20100033C15","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1115\/IMECE2004-60024","article-title":"Modeling the geometry, hemodynamics and tissue mechanics of cerebral aneurysms","author":"Ma,","year":"2004","journal-title":"Proc. of IMECE: ASME Int. Mechanical Engineering Congress and Exposition, Advances in Bioengineering"},{"key":"2026022414450184800_RSFS20100033C16","article-title":"Modeling the geometry, hemodynamics, and tissue mechanics of cerebral aneurysms","author":"Ma,","year":"2004"},{"key":"2026022414450184800_RSFS20100033C17","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev.bioeng.10.061807.160439","article-title":"Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models","volume":"10","author":"Humphrey,","year":"2008","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"2026022414450184800_RSFS20100033C18","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1109\/TMI.2005.844159","article-title":"Efficient pipeline for image-based patient-specific analysis of cerebral aneurysm hemodynamics: technique and sensitivity","volume":"24","author":"Cebral,","year":"2005","journal-title":"IEEE Trans. Med. Imag."},{"key":"2026022414450184800_RSFS20100033C19","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1098\/rsta.2010.0095","article-title":"Toward integrated management of cerebral aneurysms","volume":"368","author":"Villa-Uriol,","year":"2010","journal-title":"Phil. Trans. R. Soc. A"},{"key":"2026022414450184800_RSFS20100033C20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/00006123-199907000-00028","article-title":"Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms","volume":"45","author":"Ujiie,","year":"1999","journal-title":"Neurosurgery"},{"key":"2026022414450184800_RSFS20100033C21","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1023\/B:ABME.0000012746.31343.92","article-title":"Three-dimensional geometrical characterization of cerebral aneurysms","volume":"32","author":"Ma,","year":"2004","journal-title":"Ann. Biomed. Eng."},{"key":"2026022414450184800_RSFS20100033C22","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3171\/jns.2005.102.2.0355","article-title":"Quantified aneurysm shape and rupture risk","volume":"102","author":"Raghavan,","year":"2005","journal-title":"J. Neurosurg."},{"key":"2026022414450184800_RSFS20100033C23","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1109\/TMI.2007.901008","article-title":"Morphological characterization of intracranial aneurysms using 3-D moment invariants","volume":"26","author":"Millan,","year":"2007","journal-title":"IEEE Trans. Med. Imag."},{"key":"2026022414450184800_RSFS20100033C24","first-page":"559","article-title":"Image-based computational simulation of flow dynamics in a giant intracranial aneurysm","volume":"24","author":"Steinman,","year":"2003","journal-title":"Am. J. Neuroradiol."},{"key":"2026022414450184800_RSFS20100033C25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1001\/archneur.1963.00460030056005","article-title":"Histopathology of cerebral aneurysms","volume":"8","author":"Stehbens,","year":"1963","journal-title":"Arch. Neurol."},{"key":"2026022414450184800_RSFS20100033C26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/978-1-4613-3207-7_12","article-title":"Arterial structure at branches and bifurcations with reference to physiological and pathological processes, including aneurysm formation","volume-title":"Structure and function of the circulation","author":"Stehbens,","year":"1981"},{"key":"2026022414450184800_RSFS20100033C27","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/10255840108908009","article-title":"Multiaxial mechanical behavior of human saccular aneurysms","volume":"4","author":"Seshaiyer,","year":"2001","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"2026022414450184800_RSFS20100033C28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1115\/1.2401187","article-title":"Nonlinear anisotropic stress analysis of anatomically realistic cerebral Aneurysms","volume":"129","author":"Ma,","year":"2007","journal-title":"Trans. ASME J. Biomech. Eng."},{"key":"2026022414450184800_RSFS20100033C29","author":"Berti,","year":"2010"},{"key":"2026022414450184800_RSFS20100033C30","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.1016\/j.cma.2009.02.004","article-title":"Open problems in computational vascular biomechanics: hemodynamics and arterial wall mechanics","volume":"198","author":"Taylor,","year":"2009","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"2026022414450184800_RSFS20100033C31","doi-asserted-by":"crossref","DOI":"10.3174\/ajnr.A2306","article-title":"Patient-specific computational hemodynamics of intracranial aneurysms from 3DRA and CTA: an in vivo reproducibility study","author":"Geers,","year":"2011","journal-title":"Am. J. Neuroradiol."},{"key":"2026022414450184800_RSFS20100033C32","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1080\/10255840802654335","article-title":"Influence of inlet boundary conditions on the local haemodynamics of intracranial aneurysms","volume":"12","author":"Marzo,","year":"2009","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"2026022414450184800_RSFS20100033C33","first-page":"884","article-title":"Computational haemodynamics in cerebral aneurysms: the effects of modelled versus measured boundary conditions","volume":"2","author":"Marzo,","year":"2010","journal-title":"Ann. Biomed. Eng."},{"key":"2026022414450184800_RSFS20100033C34","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3174\/ajnr.A0848","article-title":"Detection of aneurysms by 64-section multidetector CT angiography in patients acutely suspected of having an intracranial aneurysm and comparison with digital subtraction and 3D rotational angiography","volume":"29","author":"McKinney,","year":"2008","journal-title":"Am. J. Neuroradiol."},{"key":"2026022414450184800_RSFS20100033C35","doi-asserted-by":"publisher","first-page":"976","DOI":"10.3174\/ajnr.A0964","article-title":"3D rotational angiography: the new gold standard in the detection of additional intracranial aneurysms","volume":"29","author":"van Rooij,","year":"2008","journal-title":"Am. J. Neuroradiol."},{"key":"2026022414450184800_RSFS20100033C36","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.media.2007.01.002","article-title":"Non-parametric geodesic active regions: method and evaluation for cerebral aneurysms segmentation in 3DRA and CTA","volume":"11","author":"Hernandez,","year":"2007","journal-title":"Med. Image Anal."},{"key":"2026022414450184800_RSFS20100033C37","doi-asserted-by":"publisher","first-page":"691419","DOI":"10.1117\/12.770564","article-title":"Image intensity standardization in 3D rotational angiography and its application to vascular segmentation","volume-title":"SPIE Medical Imaging 2008: Image Processing, San Diego, CA, USA","author":"Bogunovi\u0107,","year":"2008"},{"key":"2026022414450184800_RSFS20100033C38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1118\/1.3515749","article-title":"Automated segmentation of cerebral vasculature with aneurysms in 3DRA and TOF-MRA using geodesic active regions: an evaluation study","volume":"38","author":"Bogunovic,","year":"2011","journal-title":"Med. Phys."},{"key":"2026022414450184800_RSFS20100033C39","article-title":"Flux driven medial curve extraction","author":"Mellado,","year":"2007","journal-title":"Insight J."},{"key":"2026022414450184800_RSFS20100033C40","doi-asserted-by":"publisher","first-page":"H208","DOI":"10.1152\/ajpheart.00037.2009","article-title":"Validation of a one-dimensional model of the systemic arterial tree","volume":"297","author":"Reymond,","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2026022414450184800_RSFS20100033C41","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1109\/TPAMI.2010.139","article-title":"Efficient 3D Geometric and Zernike moments computation from unstructured surface meshes","volume":"33","author":"Pozo,","year":"2011","journal-title":"IEEE Trans. Pattern Anal. Machine Intell."},{"key":"2026022414450184800_RSFS20100033C42","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1109\/IEMBS.2010.5627610","article-title":"Morphological descriptors as rupture indicators in middle cerebral artery aneurysms","author":"Valencia,","year":"2010","journal-title":"Proc. IEEE EMBS. EMBC"},{"key":"2026022414450184800_RSFS20100033C43","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.media.2009.10.005","article-title":"Automated detection of intracranial aneurysms based on parent vessel 3D analysis","volume":"14","author":"Lauric,","year":"2010","journal-title":"Med. Image Anal."},{"key":"2026022414450184800_RSFS20100033C44","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1259\/bjr\/67593727","article-title":"An objective approach to digital removal of saccular aneurysms: technique and applications","volume":"82","author":"Ford,","year":"2009","journal-title":"Bri. J. Radiol."},{"key":"2026022414450184800_RSFS20100033C45","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1109\/ISBI.2010.5490172","article-title":"Neck localization and geometry quantification of intracranial aneurysms","author":"Sgouritsa,","year":"2010","journal-title":"IEEE Int. Symp. Biomed. Imag."},{"key":"2026022414450184800_RSFS20100033C46","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1109\/IEMBS.2010.5626075","article-title":"Automated intracranial aneurysm isolation and quantification","volume-title":"Proc. IEEE EMBS. EMBC","author":"Larrabide,","year":"2010"},{"key":"2026022414450184800_RSFS20100033C47","article-title":"The FEANOR source code","author":"Schmidt,","year":"2010"},{"key":"2026022414450184800_RSFS20100033C48","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1145\/1084805.1084812","article-title":"A survey of data provenance in e-science","volume":"34","author":"Simmhan,","year":"2005","journal-title":"SIGMOD Record"},{"key":"2026022414450184800_RSFS20100033C49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2009\/760364","article-title":"The role of computational fluid dynamics in the management of unruptured intracranial aneurysms: a clinicians' view","volume":"2009","author":"Singh,","year":"2009","journal-title":"Comput. Intell. Neurosci."},{"key":"2026022414450184800_RSFS20100033C50","doi-asserted-by":"publisher","first-page":"65111F","DOI":"10.1117\/12.708955","article-title":"Combined clinical and computational information in complex cerebral aneurysms: application to mirror cerebral aneurysms","volume-title":"SPIE Medical Imaging: Physiology, Function, and Structure from Medical Images, San Diego, CA, USA","author":"Radaelli,","year":"2007"},{"key":"2026022414450184800_RSFS20100033C51","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.clineuro.2009.12.018","article-title":"Effects of smoking and hypertension on wall shear stress and oscillatory shear index at the site of intracranial aneurysm formation","volume":"112","author":"Singh,","year":"2010","journal-title":"Clin. Neurol. Neurosurg."},{"key":"2026022414450184800_RSFS20100033C52","first-page":"17","article-title":"The effects of aortic coarctation on cerebral hemodynamics and its importance in the etiopathogenesis of intracranial aneurysms","volume":"3","author":"Singh,","year":"2010","journal-title":"J. Vasc. Interv. Neurol."},{"key":"2026022414450184800_RSFS20100033C53","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3174\/ajnr.A2398","article-title":"Aneurysm rupture following treatment with flow-diverting stents: computational hemodynamics analysis of treatment","volume":"32","author":"Cebral,","year":"2010","journal-title":"Am. J. Neuroradiol."},{"key":"2026022414450184800_RSFS20100033C54","article-title":"Fast virtual deployment of self-expandable stents: method and in vitro evaluation for intracranial aneurysmal stenting","author":"Larrabide,","year":"2011","journal-title":"Med. Image Anal."},{"key":"2026022414450184800_RSFS20100033C55","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1016\/j.jbiomech.2008.04.035","article-title":"Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model: A report on the Virtual Intracranial Stenting Challenge 2007","volume":"41","author":"Radaelli,","year":"2008","journal-title":"J. Biomech."},{"key":"2026022414450184800_RSFS20100033C56","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1109\/ISBI.2009.5193280","article-title":"Hemodynamic alterations of a patient-specific intracranial aneurysm induced by virtual deployment of stents in various axial orientation","volume-title":"IEEE Int. Symp. Biomed. Imag., Boston, MA, USA","author":"Kim,","year":"2009"},{"key":"2026022414450184800_RSFS20100033C57","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/ng.563","article-title":"Genome-wide association study of intracranial aneurysm identifies three new risk loci","volume":"42","author":"Yasuno,","year":"2010","journal-title":"Nat. Genet."}],"container-title":["Interface Focus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsfs.2010.0033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsfs.2010.0033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rsfs\/article-pdf\/1\/3\/308\/133579\/rsfs.2010.0033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rsfs\/article-pdf\/1\/3\/308\/133579\/rsfs.2010.0033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:45:12Z","timestamp":1771962312000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rsfs\/article\/1\/3\/308\/27336\/neurIST-complex-information-processing-toolchain"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,6]]},"references-count":57,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,4,6]]},"published-print":{"date-parts":[[2011,6,6]]}},"URL":"https:\/\/doi.org\/10.1098\/rsfs.2010.0033","relation":{},"ISSN":["2042-8898","2042-8901"],"issn-type":[{"value":"2042-8898","type":"print"},{"value":"2042-8901","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,6]]},"assertion":[{"value":"2010-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}