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The significance of cardiac disease has motivated the application of state-of-the-art clinical imaging techniques and functional signal analysis to aid diagnosis and clinical planning. Measurements of cardiac function currently provide high-resolution datasets for characterizing cardiac patients. However, the clinical practice of using population-based metrics derived from separate image or signal-based datasets often indicates contradictory treatments plans owing to inter-individual variability in pathophysiology. To address this issue, the goal of our work, demonstrated in this study through four specific clinical applications, is to integrate multiple types of functional data into a consistent framework using multi-scale computational modelling.<\/jats:p>","DOI":"10.1098\/rsfs.2010.0048","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T12:47:50Z","timestamp":1310474870000},"page":"349-364","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":122,"title":["euHeart: personalized and integrated cardiac care using patient-specific cardiovascular modelling"],"prefix":"10.1098","volume":"1","author":[{"given":"Nic","family":"Smith","sequence":"first","affiliation":[{"name":"St Thomas' Hospital, King's College London 1 , ,"},{"name":"London, UK 1 , ,"},{"name":"University of Oxford 2 , ,"},{"name":"Oxford, UK 2 , ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaide","family":"de Vecchi","sequence":"additional","affiliation":[{"name":"St Thomas' Hospital, King's College London 1 , ,"},{"name":"London, UK 1 , ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McCormick","sequence":"additional","affiliation":[{"name":"University of Oxford 2 , ,"},{"name":"Oxford, UK 2 , ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nordsletten","sequence":"additional","affiliation":[{"name":"St Thomas' Hospital, King's College London 1 , ,"},{"name":"London, UK 1 , ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Camara","sequence":"additional","affiliation":[{"name":"Universitat Pompeu Fabra 3 , ,"},{"name":"Barcelona, Spain 3 , ,"},{"name":"Biomaterials and Nanomedicine (CIBER-BBN) 4 , ,"},{"name":"Barcelona, Spain 4 , ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro F.","family":"Frangi","sequence":"additional","affiliation":[{"name":"Universitat Pompeu Fabra 3 , ,"},{"name":"Barcelona, Spain 3 , ,"},{"name":"Biomaterials and Nanomedicine (CIBER-BBN) 4 , ,"},{"name":"Barcelona, Spain 4 , ,"},{"name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Delingette","sequence":"additional","affiliation":[{"name":"INRIA Sophia-Antipolis, Sophia Antipolis Cedex, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Sermesant","sequence":"additional","affiliation":[{"name":"INRIA Sophia-Antipolis, Sophia Antipolis Cedex, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin","family":"Relan","sequence":"additional","affiliation":[{"name":"INRIA Sophia-Antipolis, Sophia Antipolis Cedex, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Ayache","sequence":"additional","affiliation":[{"name":"INRIA Sophia-Antipolis, Sophia Antipolis Cedex, France 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"Krueger","sequence":"additional","affiliation":[{"name":"Karlsruhe Institute of Technology (KIT) 7 , ,"},{"name":"Karlsruhe, Germany 7 , ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walther H. 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