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It has been shown that H\n            <jats:sub>2<\/jats:sub>\n            S reacts with NO and its metabolites and several potentially biologically active species have been identified. Thionitrous acid (HSNO) was proposed to be an intermediate product of the reaction of\n            <jats:italic>S<\/jats:italic>\n            -nitrosothiols with H\n            <jats:sub>2<\/jats:sub>\n            S capable of crossing the membranes and causing further trans-nitrosation of proteins. Alternatively, formation of nitrosopersulfide (SSNO\n            <jats:sup>\u2212<\/jats:sup>\n            ) has been proposed in this reaction. SSNO\n            <jats:sup>\u2212<\/jats:sup>\n            was claimed to be particularly stable and inert to H\n            <jats:sub>2<\/jats:sub>\n            S, thiols and cyanides. It is suggested that this putative SSNO\n            <jats:sup>\u2212<\/jats:sup>\n            slowly decomposes to give NO, HNO and polysulfides. However, the chemical studies with pure SSNO\n            <jats:sup>\u2212<\/jats:sup>\n            salts showed some conflicting observations. In this study, we work with pure PNP\n            <jats:sup>+<\/jats:sup>\n            SSNO\n            <jats:sup>\u2212<\/jats:sup>\n            to show that contrary to everything that is claimed for the yellow reaction product of GSNO with H\n            <jats:sub>2<\/jats:sub>\n            S, pure SSNO\n            <jats:sup>\u2212<\/jats:sup>\n            decomposes readily in the presence of cyanide, H\n            <jats:sub>2<\/jats:sub>\n            S and glutathione to form SNO\n            <jats:sup>\u2212<\/jats:sup>\n            . Based on literature overview and chemical data about the structures of HSNO\/SNO\n            <jats:sup>\u2212<\/jats:sup>\n            and SSNO\n            <jats:sup>\u2212<\/jats:sup>\n            we discuss the biological role these two species could have.\n          <\/jats:p>","DOI":"10.1098\/rsfs.2016.0139","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T10:10:10Z","timestamp":1487326210000},"page":"20160139","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Nitrosopersulfide (SSNO\n            <sup>\u2212<\/sup>\n            ) decomposes in the presence of sulfide, cyanide or glutathione to give HSNO\/SNO\n            <sup>\u2212<\/sup>\n            : consequences for the assumed role in cell signalling"],"prefix":"10.1098","volume":"7","author":[{"given":"Rudolf","family":"Wedmann","sequence":"first","affiliation":[{"name":"Department of Chemistry and Pharmacy, Friedrich-Alexander University of Erlangen-Nuremberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Ivanovic-Burmazovic","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmacy, Friedrich-Alexander University of Erlangen-Nuremberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0060-0041","authenticated-orcid":false,"given":"Milos R.","family":"Filipovic","sequence":"additional","affiliation":[{"name":"University of Bordeaux, IBGC, UMR 5095, 33077 Bordeaux, France"},{"name":"CNRS, IBGC, UMR 5095, 33077 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.05.005"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.268re2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.240242"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199919"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.920991"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.795"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3583fje"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2014.11.040"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5381"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3009693"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111389"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.12.017"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.06.003"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201305669"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004093"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005478"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.06.029"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202916109"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.05.007"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6878"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321871111"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.235119"},{"key":"e_1_3_3_28_2","article-title":"Ap39, a mitochondria-targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling","author":"Karwi GQ","journal-title":"Br. 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