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Interpreting the predicted outcomes of a public health decision requires not only high-quality modelling but also an ethical framework for assessing the benefits and harms associated with different options. The design and specification of ethical frameworks matured independently of computational modelling, so many values recognized as important for ethical decision-making are missing from computational models. We demonstrate a proof-of-concept approach to incorporate multiple public health values into the evaluation of a simple computational model for vaccination against a pathogen such as SARS-CoV-2. By examining a bounded space of alternative prioritizations of three values relevant to public health ethics (aggregate clinical burden, equity in clinical burden, equity in adverse effects from vaccination), we identify value trade-offs, where the outcomes of optimal strategies differ depending on the ethical framework. This work demonstrates an approach to incorporating diverse values into decision criteria used to evaluate outcomes of models of infectious disease interventions.<\/jats:p>","DOI":"10.1098\/rsfs.2025.0004","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:53:04Z","timestamp":1758873184000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Including frameworks of public health ethics in computational modelling of infectious disease interventions"],"prefix":"10.1098","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1824-7653","authenticated-orcid":true,"given":"Alexander E.","family":"Zarebski","sequence":"first","affiliation":[{"name":"University of Melbourne School of Mathematics and Statistics","place":["Parkville, Australia"]},{"name":"University of Oxford Pandemic Sciences Institute","place":["Oxford, UK"]},{"name":"MRC Biostatistics Unit","place":["Cambridge, UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-5960","authenticated-orcid":true,"given":"Nefel","family":"Tellioglu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity","place":["Melbourne, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-1010","authenticated-orcid":true,"given":"Jessica E.","family":"Stockdale","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Simon Fraser University","place":["Burnaby, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-6987","authenticated-orcid":true,"given":"Julie A.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Information Systems and Modeling Group, Los Alamos National Laboratory","place":["Los Alamos, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-0470","authenticated-orcid":true,"given":"Wasiur R.","family":"KhudaBukhsh","sequence":"additional","affiliation":[{"name":"School of Mathematical Sciences, University of Nottingham","place":["Nottingham, UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-0405","authenticated-orcid":true,"given":"Joel C.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Mathematical and Physical Sciences, La Trobe University","place":["Melbourne, Australia"]},{"name":"Australian Centre for AI in Medical Innovation","place":["Melbourne, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-4049","authenticated-orcid":true,"given":"Cameron","family":"Zachreson","sequence":"additional","affiliation":[{"name":"The University of Melbourne School of Computing and Information Systems","place":["Parkville, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordhb\/9780190245191.001.0001"},{"key":"e_1_3_8_3_2","first-page":"796","volume-title":"The Oxford handbook of public health ethics","author":"Smith M","year":"2019","unstructured":"Smith M, Upshur R. 2019 Pandemic disease, public health, and ethics. 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