{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:09:55Z","timestamp":1785877795265,"version":"3.56.0"},"reference-count":21,"publisher":"The Royal Society","issue":"11","license":[{"start":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T00:00:00Z","timestamp":1155600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2006,12,22]]},"abstract":"<jats:p>\n            In order to study the pathobiological impact of the nanometre-scale of materials, we evaluated the effects of five different materials as nanoparticulate biomaterials in comparison with bulk samples in contact with living tissues. Five groups out of 10 rats were implanted bilaterally for up to 12 months with materials of the same type, namely TiO\n            <jats:sub>2<\/jats:sub>\n            , SiO\n            <jats:sub>2<\/jats:sub>\n            , Ni, Co and polyvinyl chloride (PVC), subcutaneously with bulk material on one side of the vertebral column and intramuscularly with nanoparticulate material on the contralateral side. At the end of each implantation time, the site was macroscopically examined, followed by histological processing according to standard techniques. Malignant mesenchymal tumours (pleomorphic sarcomas) were obtained in five out of six cases of implanted Co nanoparticle sites, while a preneoplastic lesion was observed in an animal implanted with Co in bulk form. In the Ni group, all animals rapidly developed visible nodules at the implanted sites between 4 and 6 months, which were diagnosed as rhabdomyosarcomas. Since the ratio of surface area to volume did not show significant differences between the Ni\/Co group and the TiO\n            <jats:sub>2<\/jats:sub>\n            \/SiO\n            <jats:sub>2<\/jats:sub>\n            \/PVC group, we suggested that the induction of neoplasia was not mediated by physical effects, but was mediated by the well-known carcinogenic impact of Ni and Co. The data from the Co group show that the physical properties (particulate versus bulk form) could have a significant influence on the acceleration of the neoplastic process.\n          <\/jats:p>","DOI":"10.1098\/rsif.2006.0145","type":"journal-article","created":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T20:08:47Z","timestamp":1155758927000},"page":"767-775","source":"Crossref","is-referenced-by-count":55,"title":["Biological tolerance of different materials in bulk and nanoparticulate form in a rat model: sarcoma development by nanoparticles"],"prefix":"10.1098","volume":"3","author":[{"given":"Torsten","family":"Hansen","sequence":"first","affiliation":[{"name":"Institute of Pathology, Johannes Gutenberg-University of MainzLangenbeckstr. 1, 55101 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Clermont","sequence":"additional","affiliation":[{"name":"Biomatech S.A., Zone Industrielle de I'Islon115 Rue Pasteur, 38670 Chasse-sur-Rh\u00f4ne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Alves","sequence":"additional","affiliation":[{"name":"Biomatech S.A., Zone Industrielle de I'Islon115 Rue Pasteur, 38670 Chasse-sur-Rh\u00f4ne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosy","family":"Eloy","sequence":"additional","affiliation":[{"name":"Biomatech S.A., Zone Industrielle de I'Islon115 Rue Pasteur, 38670 Chasse-sur-Rh\u00f4ne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Brochhausen","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Johannes Gutenberg-University of MainzLangenbeckstr. 1, 55101 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Pierre","family":"Boutrand","sequence":"additional","affiliation":[{"name":"Biomatech S.A., Zone Industrielle de I'Islon115 Rue Pasteur, 38670 Chasse-sur-Rh\u00f4ne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta M","family":"Gatti","sequence":"additional","affiliation":[{"name":"Laboratorio dei Biomateriali, Universita degli studi di Modena e Reggio EmiliaVia Campi 231a, 41100 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"James Kirkpatrick","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Johannes Gutenberg-University of MainzLangenbeckstr. 1, 55101 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2006,8,15]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100215"},{"key":"e_1_3_2_3_1","first-page":"268","article-title":"Induction of testicular sarcomas in Fischer rats by intratesticular injection of Nickel subsulfide","volume":"38","author":"Damjanov I","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_3_2_4_1","unstructured":"Fletcher C.D.M Unni K.K& Mertens F. 2002 Pathology and genetics of tumours of soft tissue and bone. Lyon:IARC Press."},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367781780959062"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1078\/0065-1281-00649"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-2993(99)80079-7"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2003.08.021"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2002.0686"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65014-6"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.58.10.619"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200004)190:5<523::AID-PATH578>3.0.CO;2-#"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.50.99"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.165"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7339"},{"key":"e_1_3_2_16_1","first-page":"321","article-title":"Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammation","volume":"15","author":"Peters K","year":"2004","journal-title":"J. Mater. Sci"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1243\/0954411971534304"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03251-A"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1988.tb01579.x"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/089583701753338631"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367777780959157"},{"key":"e_1_3_2_22_1","first-page":"299","article-title":"Metal-induced sarcoma. A case report and literature review","volume":"252","author":"Ward J.J","year":"1990","journal-title":"Clin. Orthop"}],"container-title":["Journal of The Royal Society Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2006.0145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsif.2006.0145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2006.0145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T20:12:16Z","timestamp":1613851936000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsif.2006.0145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,15]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,12,22]]}},"alternative-id":["10.1098\/rsif.2006.0145"],"URL":"https:\/\/doi.org\/10.1098\/rsif.2006.0145","relation":{},"ISSN":["1742-5689","1742-5662"],"issn-type":[{"value":"1742-5689","type":"print"},{"value":"1742-5662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,15]]}}}