{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:21:23Z","timestamp":1789964483223,"version":"4.0.1"},"reference-count":49,"publisher":"The Royal Society","issue":"34","license":[{"start":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T00:00:00Z","timestamp":1222732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2009,5,6]]},"abstract":"<jats:p>\n                    Owing to similarity in both ionic size and polarity, strontium (Sr\n                    <jats:sup>2+<\/jats:sup>\n                    ) is known to behave in a comparable way to calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ), and its role in bone metabolism has been well documented as both anti-resorptive and bone forming. In this study, novel quaternary strontium-doped phosphate-based glasses, containing 1, 3 and 5\u200amol% SrO, were synthesized and characterized.\n                    <jats:sup>31<\/jats:sup>\n                    P magic angle spinning (MAS) nuclear magnetic resonance results showed that, as the Sr\n                    <jats:sup>2+<\/jats:sup>\n                    content is increased in the glasses, there is a slight increase in disproportionation of\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    phosphorus environments into\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sup>1<\/jats:sup>\n                    and\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sup>3<\/jats:sup>\n                    environments. Moreover, shortening and strengthening of the phosphorus to bridging oxygen distance occurred as obtained from FTIR. The general broadening of the spectral features with Sr\n                    <jats:sup>2+<\/jats:sup>\n                    content is most probably due to the increased variation of the phosphate\u2013cation bonding interactions caused by the introduction of the third cation. This increased disorder may be the cause of the increased degradation of the Sr-containing glasses relative to the Sr-free glass. As confirmed from elemental analysis, all Sr-containing glasses showed higher Na\n                    <jats:sub>2<\/jats:sub>\n                    O than expected and this also could be accounted for by the higher degradation of these glasses compared with Sr-free glasses. Measurements of surface free energy (SFE) showed that incorporation of strontium had no effect on SFE, and samples had relatively higher fractional polarity, which is not expected to promote high cell activity. From viability studies, however, the incorporation of Sr\n                    <jats:sup>2+<\/jats:sup>\n                    showed better cellular response than Sr\n                    <jats:sup>2+<\/jats:sup>\n                    -free glasses, but still lower than the positive control. This unfavourable cellular response could be due to the high degradation nature of these glasses and not due to the presence of Sr\n                    <jats:sup>2+<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1098\/rsif.2008.0348","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T09:04:08Z","timestamp":1222851848000},"page":"435-446","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":149,"title":["Structure and properties of strontium-doped phosphate-based glasses"],"prefix":"10.1098","volume":"6","author":[{"given":"Ensanya A","family":"Abou Neel","sequence":"first","affiliation":[{"name":"Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute256 Gray's Inn Road, London WC1X 8LD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Chrzanowski","sequence":"additional","affiliation":[{"name":"Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute256 Gray's Inn Road, London WC1X 8LD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Pickup","sequence":"additional","affiliation":[{"name":"School of Physical Sciences, University of KentCanterbury CT2 7NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke A","family":"O'Dell","sequence":"additional","affiliation":[{"name":"Department of Physics, University of WarwickCoventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola J","family":"Mordan","sequence":"additional","affiliation":[{"name":"Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute256 Gray's Inn Road, London WC1X 8LD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Newport","sequence":"additional","affiliation":[{"name":"School of Physical Sciences, University of KentCanterbury CT2 7NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Physics, University of WarwickCoventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C","family":"Knowles","sequence":"additional","affiliation":[{"name":"Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute256 Gray's Inn Road, London WC1X 8LD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2008,9,30]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-3079-5"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.07.024"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2005.05.001"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.03.018"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-3313-1"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.10.013"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328205049396"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.08.054"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3093(90)91043-Q"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3093(95)00280-4"},{"key":"e_1_3_2_12_1","unstructured":"Drake C. 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