{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:00:30Z","timestamp":1791327630687,"version":"4.3.1"},"reference-count":40,"publisher":"The Royal Society","issue":"suppl_3","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2009,6,6]]},"abstract":"<jats:p>Several porous calcium hydroxyapatite (HA) ceramics have been used clinically as bone substitutes, but most of them possessed few interpore connections, resulting in pathological fracture probably due to poor bone formation within the substitute. We recently developed a fully interconnected porous HA ceramic (IP-CHA) by adopting the \u2018foam-gel\u2019 technique. The IP-CHA had a three-dimensional structure with spherical pores of uniform size (average 150\u200a\u03bcm, porosity 75%), which were interconnected by window-like holes (average diameter 40\u200a\u03bcm), and also demonstrated adequate compression strength (10\u201312\u200aMPa). In animal experiments, the IP-CHA showed superior osteoconduction, with the majority of pores filled with newly formed bone. The interconnected porous structure facilitates bone tissue engineering by allowing the introduction of mesenchymal cells, osteotropic agents such as bone morphogenetic protein or vasculature into the pores. Clinically, we have applied the IP-CHA to treat various bony defects in orthopaedic surgery, and radiographic examinations demonstrated that grafted IP-CHA gained radiopacity more quickly than the synthetic HA in clinical use previously. We review the accumulated data on bone tissue engineering using the novel scaffold and on clinical application in the orthopaedic field.<\/jats:p>","DOI":"10.1098\/rsif.2008.0425.focus","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T02:04:47Z","timestamp":1230084287000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":163,"title":["Interconnected porous hydroxyapatite ceramics for bone tissue engineering"],"prefix":"10.1098","volume":"6","author":[{"given":"Hideki","family":"Yoshikawa","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine2-2 Yamadaoka, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Tamai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine2-2 Yamadaoka, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Murase","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine2-2 Yamadaoka, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Myoui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine2-2 Yamadaoka, Suita 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2008,12,23]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/1076327041348338"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199608000-00037"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(98)90613-9"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199505000-00012"},{"key":"e_1_3_2_6_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0030-5898(20)30395-3","article-title":"Hydroxyapatite and tricalcium phosphate bone graft substitute","volume":"18","author":"Bucholz R.W.","year":"1987","journal-title":"Orthop. 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