{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:39:10Z","timestamp":1790699950997,"version":"4.1.0"},"reference-count":162,"publisher":"The Royal Society","issue":"44","license":[{"start":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T00:00:00Z","timestamp":1256083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2010,3,6]]},"abstract":"<jats:p>Current drug treatments for post-menopausal osteoporosis cannot eliminate bone fractures, possibly because the mechanisms responsible for bone loss are not fully understood. Although research within various disciplines has significantly advanced the state of knowledge, fundamental findings are not widely understood between different disciplines. For that reason, this paper presents noteworthy experimental findings from discrete disciplines focusing on post-menopausal osteoporosis. These studies have established that, in addition to bone loss, significant changes in bone micro-architecture, tissue composition and micro-damage occur. Cellular processes and molecular signalling pathways governing pathological bone resorption have been identified to a certain extent. Ongoing studies endeavour to determine how such changes are initiated at the onset of oestrogen deficiency. It emerges that, because of the discrete nature of previous research studies, the sequence of events that lead to bone fracture is not fully understood. In this paper, two sequences of multi-scale changes are proposed and the experimental challenges that need to be overcome to fully define this sequence are outlined. Future studies must comprehensively characterize the time sequence of molecular-, cellular- and tissue-level changes to attain a coherent understanding of the events that ultimately lead to bone fracture and inform the future development of treatments for post-menopausal osteoporosis.<\/jats:p>","DOI":"10.1098\/rsif.2009.0282","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T20:34:53Z","timestamp":1256157293000},"page":"353-372","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":105,"title":["Perspective on post-menopausal osteoporosis: establishing an interdisciplinary understanding of the sequence of events from the molecular level to whole bone fractures"],"prefix":"10.1098","volume":"7","author":[{"given":"L. M.","family":"McNamara","sequence":"first","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, National University of Ireland Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2009,10,21]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(99)00016-9"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008209309014239"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000127828.34643.b4"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01450.x"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(88)90117-2"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(96)90735-8"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00143-4"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2003.00213.x"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00275-5"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.2.214"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(93)90092-O"},{"key":"e_1_3_1_13_1","first-page":"1357","article-title":"Radiologic bone assessment in the evaluation of osteoporosis","volume":"65","author":"Brunader R.","year":"2002","journal-title":"Am. Fam. Physician"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.9.1260"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1476-2"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(85)90204-0"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.1.6"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(98)00016-5"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11066"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.32"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00975-4"},{"key":"e_1_3_1_22_1","volume-title":"Osteoporosis","author":"Compston J. E.","year":"2002"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(89)90039-1"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650071414"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2891234"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.7.1318"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.15.1889"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1984.0042"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-003-0472-0"},{"key":"e_1_3_1_30_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.20"},{"key":"e_1_3_1_31_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.63B2.7217148"},{"key":"e_1_3_1_32_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.9.1586"},{"key":"e_1_3_1_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317215"},{"key":"e_1_3_1_34_1","volume-title":"Transactions of the 53rd Annual Meeting of the Orthopaedic Research Society","author":"El-Zaim H.","year":"2007"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650050402"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2520495"},{"key":"e_1_3_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1428"},{"key":"e_1_3_1_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl0712769"},{"key":"e_1_3_1_39_1","first-page":"619","article-title":"Serum levels of immunoreactive bone sialoprotein in osteoporosis: positive relations to established biochemical parameters of bone turnover","volume":"14","author":"Fassbender W. J.","year":"2000","journal-title":"In Vivo"},{"key":"e_1_3_1_40_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027972"},{"key":"e_1_3_1_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.12190"},{"key":"e_1_3_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(81)90045-X"},{"key":"e_1_3_1_43_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196042010-00012"},{"key":"e_1_3_1_44_1","first-page":"27","article-title":"Presence of microscopic cracks in vivo in bone","volume":"8","author":"Frost H. M.","year":"1960","journal-title":"Bull. Henry Ford Hosp."},{"key":"e_1_3_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00362-8"},{"key":"e_1_3_1_46_1","first-page":"50","article-title":"Contribution of bone mineral density and bone turnover markers to the estimation of risk of osteoporotic fracture in postmenopausal women","volume":"4","author":"Garnero P.","year":"2004","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"e_1_3_1_47_1","first-page":"S389","article-title":"Genetic effects in bone turnover","volume":"9","author":"Garnero P.","year":"1994","journal-title":"J. Bone Miner. Res."},{"key":"e_1_3_1_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.17.6222-6233.2002"},{"key":"e_1_3_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.12.010"},{"key":"e_1_3_1_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096-203"},{"key":"e_1_3_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(94)90274-7"},{"key":"e_1_3_1_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005842"},{"key":"e_1_3_1_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199311000-00030"},{"key":"e_1_3_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00284-2"},{"key":"e_1_3_1_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200107150-00010"},{"key":"e_1_3_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.08.120"},{"key":"e_1_3_1_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1096-1132"},{"key":"e_1_3_1_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8562"},{"key":"e_1_3_1_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1954"},{"key":"e_1_3_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110609"},{"key":"e_1_3_1_61_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.8.1416"},{"key":"e_1_3_1_62_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607290200"},{"key":"e_1_3_1_63_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2004.19.6.938"},{"key":"e_1_3_1_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0811-7"},{"key":"e_1_3_1_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1621100"},{"key":"e_1_3_1_66_1","first-page":"500","article-title":"Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6","volume":"23","author":"Jilka R. L.","year":"1995","journal-title":"Exp. Hematol."},{"key":"e_1_3_1_67_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1039"},{"key":"e_1_3_1_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1490-4"},{"key":"e_1_3_1_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-003-0003-x"},{"key":"e_1_3_1_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-2059-x"},{"key":"e_1_3_1_71_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.4.489"},{"key":"e_1_3_1_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170112"},{"key":"e_1_3_1_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200069"},{"key":"e_1_3_1_74_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.6.1133"},{"key":"e_1_3_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00254-8"},{"key":"e_1_3_1_76_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1998.19220245.x"},{"key":"e_1_3_1_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(03)00055-4"},{"key":"e_1_3_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(03)00241-3"},{"key":"e_1_3_1_79_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3101045"},{"key":"e_1_3_1_80_1","first-page":"719","article-title":"Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity","volume":"104","author":"Kousteni S.","year":"2001","journal-title":"Cell"},{"key":"e_1_3_1_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900271"},{"key":"e_1_3_1_82_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11176"},{"key":"e_1_3_1_83_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.2.229"},{"key":"e_1_3_1_84_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S8756-3282(96)00363-8","article-title":"A sequence variation: 713\u20138delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women","volume":"20","author":"Langdahl B. L.","year":"1997","journal-title":"Bone"},{"key":"e_1_3_1_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01673415"},{"key":"e_1_3_1_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00378-9"},{"key":"e_1_3_1_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200401000-00029"},{"key":"e_1_3_1_88_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500703"},{"key":"e_1_3_1_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050032"},{"key":"e_1_3_1_90_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511303332201"},{"key":"e_1_3_1_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501164200"},{"key":"e_1_3_1_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00312-6"},{"key":"e_1_3_1_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00414-8"},{"key":"e_1_3_1_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.06.008"},{"key":"e_1_3_1_95_1","first-page":"342","article-title":"Bone tissue material properties are altered during osteoporosis","volume":"5","author":"McNamara L. M.","year":"2005","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"e_1_3_1_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2004.12.027"},{"key":"e_1_3_1_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.02.070"},{"key":"e_1_3_1_98_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2005.20.5.886"},{"key":"e_1_3_1_99_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050803"},{"key":"e_1_3_1_100_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1984.0040"},{"key":"e_1_3_1_101_1","first-page":"1839","article-title":"Biochemical studies on the structure of chick bone collagen","volume":"28","author":"Miller E. J.","year":"1969","journal-title":"Fed. Proc."},{"key":"e_1_3_1_102_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8697"},{"key":"e_1_3_1_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00444-0"},{"key":"e_1_3_1_104_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2007.1341"},{"key":"e_1_3_1_105_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441904"},{"key":"e_1_3_1_106_1","first-page":"1","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"17","author":"NIH","year":"2000","journal-title":"NIH Consens. Statement"},{"key":"e_1_3_1_107_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10004-007-0001-y"},{"key":"e_1_3_1_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00117a013"},{"key":"e_1_3_1_109_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-6-3313"},{"key":"e_1_3_1_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6613"},{"key":"e_1_3_1_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(96)00283-9"},{"key":"e_1_3_1_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02406132"},{"key":"e_1_3_1_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90274-9"},{"key":"e_1_3_1_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012252687-9\/50031-0"},{"key":"e_1_3_1_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900372"},{"key":"e_1_3_1_116_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1349"},{"key":"e_1_3_1_117_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307900100"},{"key":"e_1_3_1_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090614"},{"key":"e_1_3_1_119_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.3.528"},{"key":"e_1_3_1_120_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2003.39.2.799416"},{"key":"e_1_3_1_121_1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/00003086-198505000-00026","article-title":"Assessment of metabolic bone diseases by quantitative computed tomography","volume":"195","author":"Richardson M. L.","year":"1985","journal-title":"Clin. Orthop. Relat. Res."},{"key":"e_1_3_1_122_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.23.3.0465"},{"key":"e_1_3_1_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-2712(18)30055-6"},{"key":"e_1_3_1_124_1","doi-asserted-by":"publisher","DOI":"10.1053\/beem.2000.0068"},{"key":"e_1_3_1_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(20010315)54:4<547::AID-JBM110>3.0.CO;2-2"},{"key":"e_1_3_1_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1233-2"},{"key":"e_1_3_1_127_1","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1182\/blood.V88.7.2531.bloodjournal8872531","article-title":"Macrophage colony-stimulating factor induces substantial osteoclast generation and bone resorption in human bone marrow cultures","volume":"88","author":"Sarma U.","year":"1996","journal-title":"Blood"},{"key":"e_1_3_1_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-006-0723-y"},{"key":"e_1_3_1_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1477-1"},{"key":"e_1_3_1_130_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5423"},{"key":"e_1_3_1_131_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4561"},{"key":"e_1_3_1_132_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060102"},{"key":"e_1_3_1_133_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.6.1120"},{"key":"e_1_3_1_134_1","first-page":"E1113","article-title":"Response of normal and osteoporotic human bone cells to mechanical stress in vitro","volume":"274","author":"Sterck J. G.","year":"1998","journal-title":"Am. J. Physiol."},{"key":"e_1_3_1_135_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.11.1947"},{"key":"e_1_3_1_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00021-6"},{"key":"e_1_3_1_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.001"},{"key":"e_1_3_1_138_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1857"},{"key":"e_1_3_1_139_1","first-page":"59","article-title":"Fracture prediction for the femoral neck using finite element models","volume":"86","author":"Testi D.","year":"2001","journal-title":"Chir. Organi. Mov."},{"key":"e_1_3_1_140_1","doi-asserted-by":"publisher","DOI":"10.1080\/00218460902996424"},{"key":"e_1_3_1_141_1","first-page":"3128","article-title":"The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone","volume":"82","author":"Tomkinson A.","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"e_1_3_1_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.02.006"},{"key":"e_1_3_1_143_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-122-3-1146"},{"key":"e_1_3_1_144_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211915200"},{"key":"e_1_3_1_145_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408923200"},{"key":"e_1_3_1_146_1","first-page":"97","article-title":"The quality of trabecular bone evaluated with micro-computed tomography, FEA and mechanical testing","volume":"40","author":"Ulrich D.","year":"1997","journal-title":"Stud. Health Technol. Informat."},{"key":"e_1_3_1_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040506"},{"key":"e_1_3_1_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(03)00266-5"},{"key":"e_1_3_1_149_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.8.1527"},{"key":"e_1_3_1_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-2035-9"},{"key":"e_1_3_1_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.08.012"},{"key":"e_1_3_1_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20063"},{"key":"e_1_3_1_153_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1568"},{"key":"e_1_3_1_154_1","first-page":"3146","article-title":"Estrogen receptor polymorphism predicts the onset of natural and surgical menopause","volume":"84","author":"Weel A. E.","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"e_1_3_1_155_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215687"},{"key":"e_1_3_1_156_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.10.1569"},{"key":"e_1_3_1_157_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.4.518"},{"key":"e_1_3_1_158_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.053"},{"key":"e_1_3_1_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00172-6"},{"key":"e_1_3_1_160_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.108.135889"},{"key":"e_1_3_1_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(96)01080-8"},{"key":"e_1_3_1_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2008.05.003"},{"key":"e_1_3_1_163_1","volume-title":"12th Conf. of the European Society of Biomechancis","author":"Zioupos P.","year":"2000"}],"container-title":["Journal of The Royal Society Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2009.0282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsif.2009.0282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2009.0282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:20:10Z","timestamp":1778620810000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rsif\/article\/7\/44\/353-372\/65574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,21]]},"references-count":162,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2010,3,6]]}},"alternative-id":["10.1098\/rsif.2009.0282"],"URL":"https:\/\/doi.org\/10.1098\/rsif.2009.0282","relation":{},"ISSN":["1742-5689","1742-5662"],"issn-type":[{"value":"1742-5689","type":"print"},{"value":"1742-5662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,21]]},"assertion":[{"value":"2009-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}