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Blood flows in the lumen and through the arterial wall were simulated by Navier\u2013Stokes equations and Darcy's Law, respectively. Meanwhile, the transport of NO in the lumen and the transport of NO within the arterial wall were modelled by advection\u2013diffusion reaction equations. Coupling of fluid dynamics at the endothelium was achieved by the Kedem\u2013Katchalsky equations. The results showed that both the hydraulic conductivity of the endothelium and the non-Newtonian viscous behaviour of blood had little effect on the distribution of NO. However, the blood flow rate, stenosis severity, red blood cells (RBCs), RBC-free layer and NO production rate at the blood vessel\u2013wall interface could significantly affect the transport of NO. The theoretical study revealed that the transport of NO was significantly hindered in the disturbed flow region distal to the stenosis. The reduced NO concentration in the disturbed flow region might play an important role in the localized genesis and development of atherosclerosis.<\/jats:p>","DOI":"10.1098\/rsif.2012.0224","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T06:49:09Z","timestamp":1337150949000},"page":"2468-2478","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Nitric oxide transport in an axisymmetric stenosis"],"prefix":"10.1098","volume":"9","author":[{"given":"Xiao","family":"Liu","sequence":"first","affiliation":[{"name":"Beihang University 1 , ,"},{"name":"Beijing, People's Republic of China 1 , ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Fan","sequence":"additional","affiliation":[{"name":"Beihang University 1 , ,"},{"name":"Beijing, People's Republic of China 1 , ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. 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