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Surveillance has identified an AIV \u2018hotspot\u2019 in shorebirds at Delaware Bay, in which prevalence is estimated to exceed other monitored sites by an order of magnitude. To better understand the factors that create an AIV hotspot, we developed and parametrized a mechanistic transmission model to study the simultaneous epizootiological impacts of multi-species transmission, seasonal breeding, host migration and mixed transmission routes. We scrutinized our model to examine the potential for an AIV hotspot to serve as a \u2018gateway\u2019 for the spread of novel viruses into North America. Our findings identify the conditions under which a novel influenza virus, if introduced into the system, could successfully invade and proliferate.<\/jats:p>","DOI":"10.1098\/rsif.2012.0804","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T10:45:39Z","timestamp":1353494739000},"page":"20120804","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Dissecting a wildlife disease hotspot: the impact of multiple host species, environmental transmission and seasonality in migration, breeding and mortality"],"prefix":"10.1098","volume":"10","author":[{"given":"V. L.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA"},{"name":"Center for the Study of Complex Systems, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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