{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:21:14Z","timestamp":1790691674429,"version":"4.1.0"},"reference-count":48,"publisher":"The Royal Society","issue":"83","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2013,6,6]]},"abstract":"<jats:p>We conducted numerical experiments to study the influence of non-propagating longitudinal and circular contractions, i.e. pendular activity and segmentation, respectively, on flow and mixing in the proximal duodenum. A lattice-Boltzmann numerical method was developed to simulate the fluid mechanical consequences for each of 22 randomly selected sequences of high-definition video of real longitudinal and radial contractile activity in the isolated proximal duodenum of the rat and guinea pig. During pendular activity in the rat duodenum, the flow was characterized by regions of high shear rate. Mixing was so governed by shearing deformation of the fluid that increased the interface between adjacent domains and accelerated their inter-diffusion (for diffusion coefficients approx. less than 10<jats:sup>\u22128<\/jats:sup>m\u00b2 s<jats:sup>\u22121<\/jats:sup>). When pendular activity was associated with a slow gastric outflow characteristic of post-prandial period, the dispersion was also improved, especially near the walls. Mixing was not promoted by isolated segmentative contractions in the guinea pig duodenum and not notably influenced by pylorus outflow. We concluded that pendular activity generates mixing of viscous fluids \u2018<jats:italic>in situ<\/jats:italic>\u2019 and accelerates the diffusive mass transfer, whereas segmentation may be more important in mixing particulate suspensions with high solid volume ratios.<\/jats:p>","DOI":"10.1098\/rsif.2013.0027","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T09:15:01Z","timestamp":1364375701000},"page":"20130027","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["Fluid mechanical consequences of pendular activity, segmentation and pyloric outflow in the proximal duodenum of the rat and the guinea pig"],"prefix":"10.1098","volume":"10","author":[{"given":"Cl\u00e9ment","family":"de Loubens","sequence":"first","affiliation":[{"name":"UMR 782 G\u00e9nie et Microbiologie des Proc\u00e9d\u00e9s Alimentaires, INRA, AgroParisTech, CBAI 78850 Thiverval Grignon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger G.","family":"Lentle","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Love","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrin","family":"Hulls","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W. M.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Institute of Food, Nutrition and Human Health, Massey University, Private Bag 11222, Palmerston North, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.2307\/1310235"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/284623"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/303333"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/303334"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9449-3"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.134403"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00062.2003"},{"key":"e_1_3_1_9_2","article-title":"An expanded finite element model of the intestinal mixing of digesta","author":"Love R","year":"2012","journal-title":"Food Dig."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01200.x"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.057182"},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1152\/ajplegacy.1902.6.5.251","article-title":"The movements of the intestines studied by means of the Rontgen rays","volume":"6","author":"Cannon WB","year":"1902","journal-title":"Am. J. Physiol."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp010050"},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1152\/ajplegacy.1975.228.6.1887","article-title":"Longitudinal contractions in duodenum: their fluid\u2013mechanical function","volume":"228","author":"Melville J","year":"1975","journal-title":"Am. J. Physiol."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01923.x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.fl.12.010180.001035"},{"key":"e_1_3_1_17_2","first-page":"G541","article-title":"Modeling the effect of wall movement on absorption in the intestine","volume":"243","author":"Macagno EO","year":"1982","journal-title":"Am. J. Physiol."},{"key":"e_1_3_1_18_2","volume-title":"New advances in gastrointestinal motility research","author":"Lentle RG","year":"2013"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2004.2886"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-3575-2_3"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2010.0090"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-007-0153-8"},{"key":"e_1_3_1_23_2","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-009-8352-6","volume-title":"Low Reynolds number hydrodynamics: with special applications to particulate media","author":"Happel J","year":"1983"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1955.sp005276"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1997.0564"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/125.9.2348"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.4.G604"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1164-y"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.fluid.30.1.329"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-fluid-121108-145519"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/jcph.2000.6616"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022112087000211"},{"key":"e_1_3_1_33_2","first-page":"G525","article-title":"Analyses of normal and abnormal esophageal transport using computer-simulations","volume":"266","author":"Li MJ","year":"1994","journal-title":"Am. J. Physiol."},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1088\/1009-1963\/11\/4\/310"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/jcph.1998.6089"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/jcph.2000.6522"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2008.02.002"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.78.056706"},{"key":"e_1_3_1_39_2","unstructured":"Cartwright JHE Gouillart E Piro N Piro O& Tuval I. 2012 Geometric mixing. See http:\/\/arxiv.org\/abs\/12066894."},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00532.2010"},{"key":"e_1_3_1_41_2","volume-title":"Physical chemistry","author":"Daniels F","year":"1961"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(77)90119-9"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00664.x"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i9.1365"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-005-0490-4"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(73)90255-2"},{"key":"e_1_3_1_47_2","volume-title":"The handbook of British mammals","author":"Corbet GB","year":"1977"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-006-0068-9"},{"key":"e_1_3_1_49_2","volume-title":"An introduction to rheology","author":"Barnes HA","year":"1989"}],"container-title":["Journal of The Royal Society Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2013.0027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsif.2013.0027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2013.0027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T16:40:08Z","timestamp":1688143208000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsif.2013.0027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,6]]},"references-count":48,"journal-issue":{"issue":"83","published-print":{"date-parts":[[2013,6,6]]}},"alternative-id":["10.1098\/rsif.2013.0027"],"URL":"https:\/\/doi.org\/10.1098\/rsif.2013.0027","relation":{},"ISSN":["1742-5689","1742-5662"],"issn-type":[{"value":"1742-5689","type":"print"},{"value":"1742-5662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,6]]},"assertion":[{"value":"2013-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}