{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:14:07Z","timestamp":1778624047369,"version":"3.51.4"},"reference-count":28,"publisher":"The Royal Society","issue":"88","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2013,11,6]]},"abstract":"<jats:p>\n                    The relationship between Doppler measurements, size and growth rate in fetal growth restriction has not been defined. We used functional linear discriminant analysis (FLDA) to investigate these parameters taking account of the difficulties inherent in exploring relationships between repeated observations from a small number of cases. In 40 fetuses with severe growth restriction, serial abdominal circumference (AC), umbilical, middle cerebral artery (MCA) and ductus venosus Doppler pulsatility index measurements were recorded. In 11 singleton fetuses with normal growth, umbilical artery pulsatility index only was measured. Data were expressed as\n                    <jats:italic>z<\/jats:italic>\n                    -scores in relation to gestation and analysed longitudinally using FLDA. In severe growth restriction, the Spearman correlation coefficients between umbilical artery pulsatility index and AC\n                    <jats:italic>z<\/jats:italic>\n                    -score, MCA pulsatility index and AC\n                    <jats:italic>z<\/jats:italic>\n                    -score and ductus venosus pulsatility index\n                    <jats:italic>z<\/jats:italic>\n                    -score and AC\n                    <jats:italic>z<\/jats:italic>\n                    -score were, respectively: \u22120.36,\n                    <jats:italic>p<\/jats:italic>\n                    = 4.4 \u00d7 10\n                    <jats:sup>\u22127<\/jats:sup>\n                    ; 0.70,\n                    <jats:italic>p<\/jats:italic>\n                    = 1.1 \u00d7 10\n                    <jats:sup>\u221217<\/jats:sup>\n                    and \u22120.50,\n                    <jats:italic>p<\/jats:italic>\n                    = 8.1 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    . No relationship was seen between Doppler parameters and growth rate. There was no relationship between umbilical artery pulsatility index and AC nor growth rate in normally grown fetuses. In severe fetal growth restriction, Doppler changes are related to absolute fetal AC size, not growth rate.\n                  <\/jats:p>","DOI":"10.1098\/rsif.2013.0376","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T05:13:36Z","timestamp":1377062016000},"page":"20130376","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Defining the relationship between fetal Doppler indices, abdominal circumference and growth rate in severe fetal growth restriction using functional linear discriminant analysis"],"prefix":"10.1098","volume":"10","author":[{"given":"Alon","family":"Talmor","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia"},{"name":"Monash IVF, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneleen","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, KU Leuven, Belgium"},{"name":"Department of Obstetrics and Gynecology, University Hospitals Leuven, Campus Gasthuisberg, KU Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edile","family":"Murdoch","sequence":"additional","affiliation":[{"name":"Division of Fetal Maternal Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Missfelder-Lobos","sequence":"additional","affiliation":[{"name":"Division of Fetal Maternal Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Timmerman","sequence":"additional","affiliation":[{"name":"Division of Fetal Maternal Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Bourne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospitals Leuven, Campus Gasthuisberg, KU Leuven, Belgium"},{"name":"Imperial College London, Hammersmith Campus, Du Cane Road, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dino A.","family":"Giussani","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Lees","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospitals Leuven, Campus Gasthuisberg, KU Leuven, Belgium"},{"name":"Imperial College London, Hammersmith Campus, Du Cane Road, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199203000-00015"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(86)90086-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90457-X"},{"key":"e_1_3_2_5_2","first-page":"499","article-title":"Umbilical Doppler waveforms and placental villous angiogenesis in pregnancies complicated by fetal growth restriction","volume":"93","author":"Todros T","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90466-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2004.03.007"},{"key":"e_1_3_2_8_2","first-page":"439","article-title":"Doppler dynamics and their complex interrelation with fetal oxygen pressure, carbon dioxide pressure, and pH in growth-retarded fetuses","volume":"84","author":"Akalin-Sel T","year":"1994","journal-title":"Obstet. Gynecol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb02573.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1991.19.1-2.21"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90587-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019521"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06010019.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2002.00627.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.1.129"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00203.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.11.1469"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00297"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den382"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2578"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8947"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1868"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1994.tb13077.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9473(98)00040-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-5-15"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0960-7692.2002.00653.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6286"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103295"},{"key":"e_1_3_2_29_2","unstructured":"Lees C et al. In press. Perinatal morbidity and mortality in early onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE). Ultrasound Obstet Gynecol ."}],"container-title":["Journal of The Royal Society Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2013.0376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsif.2013.0376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2013.0376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:20:40Z","timestamp":1778620840000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rsif\/article\/64344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,6]]},"references-count":28,"journal-issue":{"issue":"88","published-print":{"date-parts":[[2013,11,6]]}},"alternative-id":["10.1098\/rsif.2013.0376"],"URL":"https:\/\/doi.org\/10.1098\/rsif.2013.0376","relation":{},"ISSN":["1742-5689","1742-5662"],"issn-type":[{"value":"1742-5689","type":"print"},{"value":"1742-5662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,6]]},"assertion":[{"value":"2013-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}