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The shear strength, gradient composition and pore structure of the bioactive coating were characterized. Osteoblast-like MG63 cells were cultured on pure PA and composite-coated PA samples. The cells' adhesion, spread and proliferation were determined using MTT assay and microscopy. The results confirm that the samples with the nHA\/PA composite coating have better cytocompatibility and have no negative effects on cells. To investigate the\n            <jats:italic>in vivo<\/jats:italic>\n            biocompatibility, both pure PA and composite-coated PA cylinders were implanted in the trochlea of rabbit femurs and studied histologically, and the bonding ability with bone were determined using push-out tests. The results show that composite-coated implants exhibit better biocompatibility and the shear strength of the composite-coated implants with host bone at 12 weeks can reach 3.49 \u00b1 0.42 MPa, which is significantly higher than that of pure PA implants. These results indicate that composite-coated PA implants have excellent biocompatibility and bonding abilities with host bone and they have the potential to be applied in repair of bone defects.\n          <\/jats:p>","DOI":"10.1098\/rsif.2014.0101","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T16:17:53Z","timestamp":1407946673000},"page":"20140101","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Interfacial and biological properties of the gradient coating on polyamide substrate for bone substitute"],"prefix":"10.1098","volume":"11","author":[{"given":"Di","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Shanxi Key Laboratory of Material Strength and Structural Impact, College of Mechanics, Taiyuan University of Technology, Taiyuan 030024, People's Republic of China"},{"name":"Research Center for Nano-Biomaterials, 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