{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:49:14Z","timestamp":1791139754051,"version":"4.1.0"},"reference-count":51,"publisher":"The Royal Society","issue":"96","license":[{"start":{"date-parts":[[2014,7,6]],"date-time":"2014-07-06T00:00:00Z","timestamp":1404604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2014,7,6]]},"abstract":"<jats:p>\n                    Current understanding of bone healing and remodelling strategies in vertebrates has traditionally relied on morphological observations through the histological analysis of thin sections. However, chemical analysis may also be used in such interpretations, as different elements are known to be absorbed and used by bone for different physiological purposes such as growth and healing. These chemical signatures are beyond the detection limit of most laboratory-based analytical techniques (e.g. scanning electron microscopy). However, synchrotron rapid scanning\u2013X-ray fluorescence (SRS\u2013XRF) is an elemental mapping technique that uniquely combines high sensitivity (ppm), excellent sample resolution (20\u2013100 \u00b5m) and the ability to scan large specimens (decimetre scale) approximately 3000 times faster than other mapping techniques. Here, we use SRS\u2013XRF combined with microfocus elemental mapping (2\u201320 \u00b5m) to determine the distribution and concentration of trace elements within pathological and normal bone of both extant and extinct archosaurs (\n                    <jats:italic>Cathartes aura<\/jats:italic>\n                    and\n                    <jats:italic>Allosaurus fragilis<\/jats:italic>\n                    ). Results reveal discrete chemical inventories within different bone tissue types and preservation modes. Chemical inventories also revealed detail of histological features not observable in thin section, including fine structures within the interface between pathological and normal bone as well as woven texture within pathological tissue.\n                  <\/jats:p>","DOI":"10.1098\/rsif.2014.0277","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T05:22:07Z","timestamp":1399526527000},"page":"20140277","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":56,"title":["Synchrotron imaging reveals bone healing and remodelling strategies in extinct and extant vertebrates"],"prefix":"10.1098","volume":"11","author":[{"given":"Jennifer","family":"Ann\u00e9","sequence":"first","affiliation":[{"name":"School of Earth, Atmospheric and Environmental Sciences, University of Manchester, Williamson Building, Oxford Road, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Edwards","sequence":"additional","affiliation":[{"name":"School of Earth, Atmospheric and Environmental Sciences, University of Manchester, Williamson Building, Oxford Road, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy A.","family":"Wogelius","sequence":"additional","affiliation":[{"name":"School of Earth, Atmospheric and Environmental Sciences, University of Manchester, Williamson Building, Oxford Road, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison R.","family":"Tumarkin-Deratzian","sequence":"additional","affiliation":[{"name":"Department of Earth and Environmental Science, Temple University, Philadelphia, PA 19122, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William I.","family":"Sellers","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, University of Manchester, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen","family":"van Veelen","sequence":"additional","affiliation":[{"name":"School of Earth, Atmospheric and Environmental Sciences, University of Manchester, Williamson Building, Oxford Road, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Bergmann","sequence":"additional","affiliation":[{"name":"SLAC National Accelerator Laboratory, Linac Coherent Light Source, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimosthenis","family":"Sokaras","sequence":"additional","affiliation":[{"name":"SLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Alonso-Mori","sequence":"additional","affiliation":[{"name":"SLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Menlo Park, CA 94025, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Ignatyev","sequence":"additional","affiliation":[{"name":"Diamond Light Source, Didcot OX11 0DE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria M.","family":"Egerton","sequence":"additional","affiliation":[{"name":"School of Earth, Atmospheric and Environmental Sciences, University of Manchester, Williamson Building, Oxford Road, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip L.","family":"Manning","sequence":"additional","affiliation":[{"name":"School of Earth, Atmospheric and Environmental Sciences, University of Manchester, Williamson Building, Oxford Road, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2014,7,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","DOI":"10.56021\/9780801881206","volume-title":"The microstructure of dinosaur bone: deciphering biology with fine-scale techniques","author":"Chinsamy-Turan A","year":"2005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","DOI":"10.1515\/9781400849505","volume-title":"Bones: structure and biomechanics","author":"Currey J","year":"2002"},{"key":"e_1_3_2_4_2","first-page":"51","article-title":"Evolution of endothermy: histological evidence","volume":"1","author":"de Ricql\u00e9s A","year":"1974","journal-title":"Evol. 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