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In large vessels, like the abdominal aorta and the carotid artery (millimetre to centimetre size), the extent of this migration and its interaction with secondary flows has not been fully elucidated. RBC migration exerts its influence primarily on platelet concentration, oxygen transport and oxygen availability at the luminal surface, which could influence vessel wall disease processes in and adjacent to the intima. Phillips' shear-induced particle migration model, coupled to the Quemada viscosity model, was employed to simulate the macroscopic behaviour of RBCs in four patient-specific geometries: a normal abdominal aorta, an abdominal aortic aneurysm (AAA), a normal carotid bifurcation and a stenotic carotid bifurcation. Simulations show a migration of RBCs from the near-wall region with a lowering of wall haematocrit (volume fraction of RBCs) on the posterior side of the normal aorta and on the lateral-external side of the iliac arteries. A marked migration is observed on the outer wall of the carotid sinus, along the common carotid artery and in the carotid stenosis. No significant migration is observed in the AAA. The spatial and temporal patterns of wall haematocrit are correlated with the near-wall shear layer and with the secondary flows induced by the vessel curvature. In particular, secondary flows accentuate the initial lowering in RBC near-wall concentration by convecting RBCs from the inner curvature side to the outer curvature side. The results reinforce data in literature showing a decrease in oxygen partial pressure on the inner curvature wall of the carotid sinus induced by the presence of secondary flows. The lowering of wall haematocrit is postulated to induce a decrease in oxygen availability at the luminal surface through a diminished concentration of oxyhaemoglobin, hence contributing, with the reported lowered oxygen partial pressure, to local hypoxia.<\/jats:p>","DOI":"10.1098\/rsif.2014.0403","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T09:21:00Z","timestamp":1400664060000},"page":"20140403","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Synergy between shear-induced migration and secondary flows on red blood cells transport in arteries: considerations on oxygen transport"],"prefix":"10.1098","volume":"11","author":[{"given":"Jacopo","family":"Biasetti","sequence":"first","affiliation":[{"name":"Department of Solid Mechanics, School of Engineering Sciences, KTH Royal Institute of Technology, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Giorgio","family":"Spazzini","sequence":"additional","affiliation":[{"name":"Mechanics Division, National Institute of Metrological Research (INRiM), Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Hedin","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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