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In this study, micro-focus X-ray scattering data were used to obtain quantitative information about lamellar inclination (with respect to the corneal surface) and the X-ray scatter intensity throughout the depth of the cornea from the centre to the temporal limbus. The average collagen inclination remained predominantly parallel to the tissue surface at all depths. However, in the central cornea, the spread of inclination angles was greatest in the anterior-most stroma (reflecting the increased lamellar interweaving in this region), and decreased with tissue depth; in the peripheral cornea inclination angles showed less variation throughout the tissue thickness. Inclination angles in the deeper stroma were generally higher in the peripheral cornea, suggesting the presence of more interweaving in the posterior stroma away from the central cornea. An increase in collagen X-ray scatter was identified in a region extending from the sclera anteriorly until about 2 mm from the corneal centre. This could arise from the presence of larger diameter fibrils, probably of scleral origin, which are known to exist in this region. Incorporation of this quantitative information into finite-element models will further improve the accuracy with which they can predict the biomechanical response of the cornea to pathology and refractive procedures.<\/jats:p>","DOI":"10.1098\/rsif.2014.0717","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T10:13:01Z","timestamp":1422439981000},"page":"20140717","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution"],"prefix":"10.1098","volume":"12","author":[{"given":"Ahmed","family":"Abass","sequence":"first","affiliation":[{"name":"Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4HQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Hayes","sequence":"additional","affiliation":[{"name":"Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4HQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"White","sequence":"additional","affiliation":[{"name":"Visual Science Bioimaging Labs (VSBL), School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4HQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Diamond Light Source Ltd, Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Meek","sequence":"additional","affiliation":[{"name":"Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff CF24 4HQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"2244","article-title":"The three-dimensional organization of collagen fibrils in the human cornea and sclera","volume":"32","author":"Komai Y","year":"1991","journal-title":"Invest. 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