{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:44:04Z","timestamp":1792676644216,"version":"4.5.0"},"reference-count":47,"publisher":"The Royal Society","issue":"108","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>\n            Mechanical loading conditions are likely to play a key role in passive and active (contractile) behaviour of lymphatic vessels. The development of a microstructurally motivated model of lymphatic tissue is necessary for quantification of mechanically mediated maladaptive remodelling in the lymphatic vasculature. Towards this end, we performed cylindrical biaxial testing of Sprague\u2013Dawley rat thoracic ducts (\n            <jats:italic>n<\/jats:italic>\n            = 6) and constitutive modelling to characterize their mechanical behaviour. Spontaneous contraction was quantified at transmural pressures of 3, 6 and 9 cmH\n            <jats:sub>2<\/jats:sub>\n            O. Cyclic inflation in calcium-free saline was performed at fixed axial stretches between 1.30 and 1.60, while recording pressure, outer diameter and axial force. A microstructurally motivated four-fibre family constitutive model originally proposed by Holzapfel\n            <jats:italic>et al<\/jats:italic>\n            . (Holzapfel\n            <jats:italic>et al<\/jats:italic>\n            . 2000\n            <jats:italic>J. Elast.<\/jats:italic>\n            61, 1\u201348. (\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1023\/A:1010835316564\">doi:10.1023\/A:1010835316564<\/jats:ext-link>\n            )) was used to quantify the passive mechanical response, and the model of Rachev and Hayashi was used to quantify the active (contractile) mechanical response. The average error between data and theory was 8.9 \u00b1 0.8% for passive data and 6.6 \u00b1 2.6% and 6.8 \u00b1 3.4% for the systolic and basal conditions, respectively, for active data. Multi-photon microscopy was performed to quantify vessel wall thickness (32.2 \u00b1 1.60 \u00b5m) and elastin and collagen organization for three loading conditions. Elastin exhibited structural \u2018fibre families\u2019 oriented nearly circumferentially and axially. Sample-to-sample variation was observed in collagen fibre distributions, which were often non-axisymmetric, suggesting material asymmetry. In closure, this paper presents a microstructurally motivated model that accurately captures the biaxial active and passive mechanical behaviour in lymphatics and offers potential for future research to identify parameters contributing to mechanically mediated disease development.\n          <\/jats:p>","DOI":"10.1098\/rsif.2015.0280","type":"journal-article","created":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T16:09:47Z","timestamp":1433347787000},"page":"20150280","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Quantification of the passive and active biaxial mechanical behaviour and microstructural organization of rat thoracic ducts"],"prefix":"10.1098","volume":"12","author":[{"given":"Alexander W.","family":"Caulk","sequence":"first","affiliation":[{"name":"The George W. 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