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Interface."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Lyme disease is the most prevalent vector-borne disease in the temperate Northern Hemisphere. The abundance of infected nymphal ticks is commonly used as a Lyme disease risk indicator. Temperature can influence the dynamics of disease by shaping the activity and development of ticks and, hence, altering the contact pattern and pathogen transmission between ticks and their host animals. A mechanistic, agent-based model was developed to study the temperature-driven seasonality of<jats:italic>Ixodes ricinus<\/jats:italic>ticks and transmission of<jats:italic>Borrelia burgdorferi sensu lato<\/jats:italic>across mainland Scotland. Based on 12-year averaged temperature surfaces, our model predicted that Lyme disease risk currently peaks in autumn, approximately six weeks after the temperature peak. The risk was predicted to decrease with increasing altitude. Increases in temperature were predicted to prolong the duration of the tick questing season and expand the risk area to higher altitudinal and latitudinal regions. These predicted impacts on tick population ecology may be expected to lead to greater tick\u2013host contacts under climate warming and, hence, greater risks of pathogen transmission. 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