{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:02:38Z","timestamp":1791226958147,"version":"4.1.0"},"reference-count":89,"publisher":"The Royal Society","issue":"123","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/royalsocietypublishing.org\/licence"},{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"Canada Research Chair Foundation"},{"DOI":"10.13039\/501100000038","name":"Natural Science and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canada Research Chair Foundation"},{"DOI":"10.13039\/501100000038","name":"Natural Science and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polar and charged amino acids (AAs) are heavily expressed in non-collagenous proteins (NCPs), and are involved in hydroxyapatite (HA) mineralization in bone. Here, we review what is known on the effect of single AAs on HA precipitation. Negatively charged AAs, such as aspartic acid, glutamic acid (Glu) and phosphoserine are largely expressed in NCPs and play a critical role in controlling HA nucleation and growth. Positively charged ones such as arginine (Arg) or lysine (Lys) are heavily involved in HA nucleation within extracellular matrix proteins such as collagen. Glu, Arg and Lys intake can also increase bone mineral density by stimulating growth hormone production. In vitro studies suggest that the role of AAs in controlling HA precipitation is affected by their mobility. While dissolved AAs are able to inhibit HA precipitation and growth by chelating Ca2+ and PO43\u2212 ions or binding to nuclei of calcium phosphate and preventing their further growth, AAs bound to surfaces can promote HA precipitation by attracting Ca2+ and PO43\u2212 ions and increasing the local supersaturation. Overall, the effect of AAs on HA precipitation is worth being investigated more, especially under conditions closer to the physiological ones, where the presence of other factors such as collagen, mineralization inhibitors, and cells heavily influences HA precipitation. A deeper understanding of the role of AAs in HA mineralization will increase our fundamental knowledge related to bone formation, and could lead to new therapies to improve bone regeneration in damaged tissues or cure pathological diseases caused by excessive mineralization in tissues such as cartilage, blood vessels and cardiac valves.<\/jats:p>","DOI":"10.1098\/rsif.2016.0462","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T05:12:47Z","timestamp":1475644367000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":250,"title":["The role of amino acids in hydroxyapatite mineralization"],"prefix":"10.1098","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-5822","authenticated-orcid":false,"given":"M.","family":"Tavafoghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-3071","authenticated-orcid":false,"given":"M.","family":"Cerruti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","reference":[{"key":"2026022414252401300_RSIF20160462C1","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1021\/ja043776z","article-title":"Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone","volume":"127","author":"Song","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"2026022414252401300_RSIF20160462C2","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1021\/cr0782729","article-title":"Phosphorylated proteins and control over apatite nucleation, crystal growth, and inhibition","volume":"108","author":"George","year":"2008","journal-title":"Chem. Rev."},{"key":"2026022414252401300_RSIF20160462C3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/BCO.0b013e32825e1d84","article-title":"The role of noncollagenous proteins in mineralization","volume":"18","author":"Rosenthal","year":"2007","journal-title":"Curr. Opin. Orthopaed."},{"key":"2026022414252401300_RSIF20160462C4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00223-013-9725-7","article-title":"Association of calcium and phosphate ions with collagen in the mineralization of vertebrate tissues","volume":"93","author":"Landis","year":"2013","journal-title":"Calcif. 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Mater. Sci."},{"key":"2026022414252401300_RSIF20160462C11","doi-asserted-by":"crossref","first-page":"8972","DOI":"10.1021\/la700567r","article-title":"Adsorption processes of Gly and Glu amino acids on hydroxyapatite surfaces at the atomic level","volume":"23","author":"Pan","year":"2007","journal-title":"Langmuir"},{"key":"2026022414252401300_RSIF20160462C12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10856-007-3179-2","article-title":"Biomimetic deposition of hydroxyapatite on a synthetic polypeptide with beta sheet structure in a solution mimicking body fluid","volume":"19","author":"Takeuchi","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"2026022414252401300_RSIF20160462C13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1098\/rsif.2005.0052","article-title":"Heterogeneous nucleation of hydroxyapatite on protein: structural effect of silk sericin","volume":"2","author":"Takeuchi","year":"2005","journal-title":"J. R. Soc. Interface"},{"key":"2026022414252401300_RSIF20160462C14","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1021\/bi00838a031","article-title":"Computed circular dichroism spectra for the evaluation of protein conformation","volume":"8","author":"Greenfield","year":"1969","journal-title":"Biochemistry"},{"key":"2026022414252401300_RSIF20160462C15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0021-9797(77)90010-8","article-title":"Adsorption of amino acids onto hydroxyapatite","volume":"59","author":"Kresak","year":"1977","journal-title":"J. Colloid Interface Sci."},{"key":"2026022414252401300_RSIF20160462C16","doi-asserted-by":"crossref","first-page":"24 553","DOI":"10.1074\/jbc.M600939200","article-title":"Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine\/glutamate antiporter","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2026022414252401300_RSIF20160462C17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1023\/A:1013291715326","article-title":"Calcification of porcine and human cardiac valves: testing of various inhibitors for antimineralization","volume":"9","author":"Koutsopoulos","year":"1998","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"2026022414252401300_RSIF20160462C18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10856-006-0050-9","article-title":"The effect of Leucine on the crystal growth of calcium phosphate","volume":"19","author":"Dalas","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"2026022414252401300_RSIF20160462C19","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1021\/la000057z","article-title":"Inhibition of hydroxyapatite formation in aqueous solutions by amino acids with hydrophobic side groups","volume":"16","author":"Koutsopoulos","year":"2000","journal-title":"Langmuir"},{"key":"2026022414252401300_RSIF20160462C20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0022-0248(00)00415-2","article-title":"Hydroxyapatite crystallization in the presence of serine, tyrosine and hydroxyproline amino acids with polar side groups","volume":"216","author":"Koutsopoulos","year":"2000","journal-title":"J. Crystal Growth"},{"key":"2026022414252401300_RSIF20160462C21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1021\/la000820p","article-title":"Hydroxyapatite crystallization in the presence of amino acids with uncharged polar side groups: glycine, cysteine, cystine, and glutamine","volume":"17","author":"Koutsopoulos","year":"2001","journal-title":"Langmuir"},{"key":"2026022414252401300_RSIF20160462C22","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0022-0248(00)00502-9","article-title":"The effect of acidic amino acids on hydroxyapatite crystallization","volume":"217","author":"Koutsopoulos","year":"2000","journal-title":"J. Crystal Growth"},{"key":"2026022414252401300_RSIF20160462C23","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1039\/b400317a","article-title":"Synthesis and characterization of amino acid-functionalized hydroxyapatite nanorods","volume":"14","author":"Gonzalez-McQuire","year":"2004","journal-title":"J. Mater. Chem."},{"key":"2026022414252401300_RSIF20160462C24","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/S0142-9612(01)00358-1","article-title":"Crystallinity and solubility characteristics of hydroxyapatite adsorbed amino acid","volume":"23","author":"Matsumoto","year":"2002","journal-title":"Biomaterials"},{"key":"2026022414252401300_RSIF20160462C25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/jcis.2002.8323","article-title":"The role of polycarboxylic acids in calcium phosphate mineralization","volume":"250","author":"Tsortos","year":"2002","journal-title":"J. Colloid Interface Sci."},{"key":"2026022414252401300_RSIF20160462C26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11706-008-0046-0","article-title":"Molecular dynamics simulations of the adsorption of amino acids on the hydroxyapatite {100}-water interface","volume":"2","author":"Zhang","year":"2008","journal-title":"Front. Mater. Sci. China"},{"key":"2026022414252401300_RSIF20160462C27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S1003-6326(07)60143-5","article-title":"Inhibition mechanism of aspartic acid on crystal growth of hydroxyapatite","volume":"17","author":"Huang","year":"2007","journal-title":"Trans. Nonferrous Metals Soc. China"},{"key":"2026022414252401300_RSIF20160462C28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0927-7757(95)03216-Z","article-title":"Transformation behaviour of calcium phosphate 2. Effects of various phosphorylated amino acids","volume":"103","author":"Wong","year":"1995","journal-title":"Colloids Surf. A"},{"key":"2026022414252401300_RSIF20160462C29","doi-asserted-by":"crossref","first-page":"9157","DOI":"10.1039\/C5TB01036E","article-title":"A potential mechanism for amino acid-controlled crystal growth of hydroxyapatite","volume":"3","author":"Wang","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"2026022414252401300_RSIF20160462C30","doi-asserted-by":"crossref","first-page":"20120906","DOI":"10.1098\/rsif.2012.0906","article-title":"The importance of amino acid interactions in the crystallization of hydroxyapatite","volume":"10","author":"Jahromi","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"2026022414252401300_RSIF20160462C31","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1021\/cg501369q","article-title":"Amino acid\/ion aggregate formation and their role in hydroxyapatite precipitation","volume":"15","author":"Jahromi","year":"2015","journal-title":"Crystal Growth Des."},{"key":"2026022414252401300_RSIF20160462C32","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1021\/jp106863q","article-title":"Unique roles of acidic amino acids in phase transformation of calcium phosphates","volume":"115","author":"Chu","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"2026022414252401300_RSIF20160462C33","doi-asserted-by":"crossref","first-page":"13 410","DOI":"10.1021\/jp0732918","article-title":"Roles of amorphous calcium phosphate and biological additives in the assembly of hydroxyapatite nanoparticles","volume":"111","author":"Tao","year":"2007","journal-title":"J. Phys. Chem. B"},{"key":"2026022414252401300_RSIF20160462C34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1134\/S1087659607030170","article-title":"The influence of amino acids on the formation of nanocrystalline hydroxyapatite","volume":"33","author":"Rosseeva","year":"2007","journal-title":"Glass Phys. Chem."},{"key":"2026022414252401300_RSIF20160462C35","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1002\/ejic.200600423","article-title":"Hydroxyapatite nanocrystals modified with acidic amino acids","volume":"2006","author":"Boanini","year":"2006","journal-title":"Eur. J. Inorg. Chem."},{"key":"2026022414252401300_RSIF20160462C36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0162-0134(02)00481-6","article-title":"The influence of amino acids on the biomineralization of hydroxyapatite in gelatin","volume":"91","author":"Eiden-A\u00dfmann","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"2026022414252401300_RSIF20160462C37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/jcis.2000.7396","article-title":"Model studies on the interaction of amino acids with biominerals: the effect of l-serine at the hydroxyapatite\u2013water interface","volume":"236","author":"Spanos","year":"2001","journal-title":"J. Colloid Interface Sci."},{"key":"2026022414252401300_RSIF20160462C38","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.apsusc.2012.07.055","article-title":"Adsorption and release of amino acids mixture onto apatitic calcium phosphates analogous to bone mineral","volume":"259","author":"El Rhilassi","year":"2012","journal-title":"Appl. Surf. Sci."},{"key":"2026022414252401300_RSIF20160462C39","article-title":"Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite","author":"El Rhilassi","journal-title":"J. Saudi Chem. Soc."},{"key":"2026022414252401300_RSIF20160462C40","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1039\/b805407j","article-title":"Calcium phosphate nanoparticles in biomineralization and biomaterials","volume":"18","author":"Cai","year":"2008","journal-title":"J. Mater. Chem."},{"key":"2026022414252401300_RSIF20160462C41","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.1063187","article-title":"Self-assembly and mineralization of peptide-amphiphile nanofibers","volume":"294","author":"Hartgerink","year":"2001","journal-title":"Science"},{"key":"2026022414252401300_RSIF20160462C42","doi-asserted-by":"crossref","first-page":"12 083","DOI":"10.1073\/pnas.95.21.12083","article-title":"A peptide that inhibits hydroxyapatite growth is in an extended conformation on the crystal surface","volume":"95","author":"Long","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026022414252401300_RSIF20160462C43","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/adma.200702322","article-title":"Identification of a highly specific hydroxyapatite-binding peptide using phage display","volume":"20","author":"Roy","year":"2008","journal-title":"Adv. Mater."},{"key":"2026022414252401300_RSIF20160462C44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0003-9969(78)90266-2","article-title":"Adsorption of two human parotid salivary macromolecules on hydroxy-, fluorhydroxy- and fluorapatites","volume":"23","author":"Moreno","year":"1978","journal-title":"Arch. Oral. Biol."},{"key":"2026022414252401300_RSIF20160462C45","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0003-9969(94)90099-X","article-title":"Hydroxyapatite mineralization and demineralization in the presence of synthetic phosphorylated pentapeptides","volume":"39","author":"Wikiel","year":"1994","journal-title":"Arch. Oral Biol."},{"key":"2026022414252401300_RSIF20160462C46","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1021\/ja984254k","article-title":"Oriented growth of calcite controlled by self-assembled monolayers of functionalized alkanethiols supported on gold and silver","volume":"121","author":"Aizenberg","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"2026022414252401300_RSIF20160462C47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/term.131","article-title":"Effect of functional end groups of silane self-assembled monolayer surfaces on apatite formation, fibronectin adsorption and osteoblast cell function","volume":"3","author":"Toworfe","year":"2009","journal-title":"J. Tissue Eng. Regener. Med."},{"key":"2026022414252401300_RSIF20160462C48","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/anie.200501654","article-title":"Self-organizing \u03b2-sheet lipopeptide monolayers as template for the mineralization of CaCO3","volume":"45","author":"Cavalli","year":"2006","journal-title":"Angew. Chem. Int. Ed."},{"key":"2026022414252401300_RSIF20160462C49","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1039\/b904440j","article-title":"Self-assembled calcium phosphate nanocomposites using block copolypeptide templates","volume":"5","author":"Hu","year":"2009","journal-title":"Soft Matter"},{"key":"2026022414252401300_RSIF20160462C50","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1016\/j.biomaterials.2003.10.022","article-title":"The effect of surface charge on hydroxyapatite nucleation","volume":"25","author":"Zhu","year":"2004","journal-title":"Biomaterials"},{"key":"2026022414252401300_RSIF20160462C51","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.msec.2006.08.002","article-title":"Biomimetic synthesis of enamel-like hydroxyapatite on self-assembled monolayers","volume":"27","author":"Li","year":"2007","journal-title":"Mater. Sci. Eng. C"},{"key":"2026022414252401300_RSIF20160462C52","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1016\/S0142-9612(02)00050-9","article-title":"The role of surface functional groups in calcium phosphate nucleation on titanium foil: a self-assembled monolayer technique","volume":"23","author":"Liu","year":"2002","journal-title":"Biomaterials"},{"key":"2026022414252401300_RSIF20160462C53","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/(SICI)1097-4636(19970305)34:3<305::AID-JBM5>3.0.CO;2-O","article-title":"Surface functional group dependence on apatite formation on self-assembled monolayers in a simulated body fluid","volume":"34","author":"Tanahashi","year":"1997","journal-title":"J. Biomed. Mater. Res."},{"key":"2026022414252401300_RSIF20160462C54","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1023\/A:1024000821368","article-title":"Apatite deposition on polyamide films containing carboxyl group in a biomimetic solution","volume":"14","author":"Miyazaki","year":"2003","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"2026022414252401300_RSIF20160462C55","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1021\/jp2102226","article-title":"Simultaneous reduction and surface functionalization of graphene oxide for hydroxyapatite mineralization","volume":"116","author":"Liu","year":"2012","journal-title":"J. Phys. Chem. C"},{"key":"2026022414252401300_RSIF20160462C56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.apsusc.2013.10.106","article-title":"Nucleation and characterization of hydroxyapatite on thioglycolic acid-capped reduced graphene oxide\/silver nanoparticles in simplified simulated body fluid","volume":"289","author":"Zhao","year":"2014","journal-title":"Appl. Surf. Sci."},{"key":"2026022414252401300_RSIF20160462C57","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1002\/jbm.a.35353","article-title":"Osteoblast response to the surface of amino acid-functionalized hydroxyapatite","volume":"103","author":"Lee","year":"2015","journal-title":"J. Biomed. Mater. Res. A"},{"key":"2026022414252401300_RSIF20160462C58","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/jbm.a.34383","article-title":"High protein adsorptive capacity of amino acid-functionalized hydroxyapatite","volume":"101","author":"Lee","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"key":"2026022414252401300_RSIF20160462C59","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1098\/rsif.2011.0586","article-title":"Modulating protein adsorption onto hydroxyapatite particles using different amino acid treatments","volume":"9","author":"Lee","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"2026022414252401300_RSIF20160462C60","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1021\/la035381j","article-title":"Mineralization mechanism of calcium phosphates under three kinds of Langmuir monolayers","volume":"20","author":"Zhang","year":"2004","journal-title":"Langmuir"},{"key":"2026022414252401300_RSIF20160462C61","doi-asserted-by":"crossref","first-page":"20150986","DOI":"10.1098\/rsif.2015.0986","article-title":"Hydroxyapatite formation on graphene oxide modified with amino acids: arginine versus glutamic acid","volume":"13","author":"Tavafoghi","year":"2016","journal-title":"J. R. Soc. Interface"},{"key":"2026022414252401300_RSIF20160462C62","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1021\/la803842g","article-title":"Density functional theory study of the binding of glycine, proline, and hydroxyproline to the hydroxyapatite (0001) and (011\u03040) surfaces","volume":"25","author":"Almora-Barrios","year":"2009","journal-title":"Langmuir"},{"key":"2026022414252401300_RSIF20160462C63","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1039\/c002146f","article-title":"Hydroxyapatite as a key biomaterial: quantum-mechanical simulation of its surfaces in interaction with biomolecules","volume":"12","author":"Corno","year":"2010","journal-title":"Phys. Chem. Chem. Phys"},{"key":"2026022414252401300_RSIF20160462C64","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/jcis.2000.7144","article-title":"The crystallization of hydroxyapatite in the presence of lysine","volume":"231","author":"Koutsopoulos","year":"2000","journal-title":"J. Colloid Interface Sci."},{"key":"2026022414252401300_RSIF20160462C65","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/jcc.23474","article-title":"Small molecule-mediated control of hydroxyapatite growth: free energy calculations benchmarked to density functional theory","volume":"35","author":"Xu","year":"2014","journal-title":"J. Comput. Chem."},{"key":"2026022414252401300_RSIF20160462C66","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1016\/j.apsusc.2012.01.116","article-title":"First-principles study of the adsorption of lysine on hydroxyapatite (1 0 0) surface","volume":"258","author":"Lou","year":"2012","journal-title":"Appl. Surf. Sci."},{"key":"2026022414252401300_RSIF20160462C67","doi-asserted-by":"crossref","first-page":"9422","DOI":"10.1016\/j.biomaterials.2010.08.064","article-title":"Phosphorylation-dependent mineral-type specificity for apatite-binding peptide sequences","volume":"31","author":"Addison","year":"2010","journal-title":"Biomaterials"},{"key":"2026022414252401300_RSIF20160462C68","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1113\/jphysiol.1937.sp003477","article-title":"The absorption of amino acids and their distribution in the body fluids","volume":"89","author":"Bolton","year":"1937","journal-title":"J. Physiol."},{"key":"2026022414252401300_RSIF20160462C69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/jcp.1041230113","article-title":"Utilization and formation of amino acids by chicken epiphyseal chondrocytes: comparative studies with cultured cells and native cartilage tissue","volume":"123","author":"Ishikawa","year":"1985","journal-title":"J. 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