{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:32:51Z","timestamp":1771061571601,"version":"3.50.1"},"reference-count":58,"publisher":"The Royal Society","issue":"137","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/F500351\/1"],"award-info":[{"award-number":["EP\/F500351\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n            The growth of bubbles within the body is widely believed to be the cause of decompression sickness (DCS). Dive computer algorithms that aim to prevent DCS by mathematically modelling bubble dynamics and tissue gas kinetics are challenging to validate. This is due to lack of understanding regarding the mechanism(s) leading from bubble formation to DCS. In this work, a biomimetic\n            <jats:italic>in vitro<\/jats:italic>\n            tissue phantom and a three-dimensional computational model, comprising a hyperelastic strain-energy density function to model tissue elasticity, were combined to investigate key areas of bubble dynamics. A sensitivity analysis indicated that the diffusion coefficient was the most influential material parameter. Comparison of computational and experimental data revealed the bubble surface's diffusion coefficient to be 30 times smaller than that in the bulk tissue and dependent on the bubble's surface area. The initial size, size distribution and proximity of bubbles within the tissue phantom were also shown to influence their subsequent dynamics highlighting the importance of modelling bubble nucleation and bubble\u2013bubble interactions in order to develop more accurate dive algorithms.\n          <\/jats:p>","DOI":"10.1098\/rsif.2017.0653","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T10:11:19Z","timestamp":1513764679000},"page":"20170653","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["A combined three-dimensional\n            <i>in vitro\u2013in silico<\/i>\n            approach to modelling bubble dynamics in decompression sickness"],"prefix":"10.1098","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3769-3392","authenticated-orcid":false,"given":"C.","family":"Walsh","sequence":"first","affiliation":[{"name":"Centre for Advanced Biomedical Imaging (CABI), University College of London, Paul O'Gorman Building, 72 Huntley Street, London, UK"},{"name":"Centre for Tissue and Cell Research, University College of London, Royal National Orthopeadic Hospital, London, UK"},{"name":"Department of Mathematics, University College of London, Gower Street, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Stride","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, Old Road Campus Research Building, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Cheema","sequence":"additional","affiliation":[{"name":"Centre for Tissue and Cell Research, University College of London, Royal National Orthopeadic Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-665X","authenticated-orcid":false,"given":"N.","family":"Ovenden","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University College of London, Gower Street, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00366641"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1122\/1.1645518"},{"key":"e_1_3_6_4_2","volume-title":"Bennett and elliott's physiology and medicine of diving","author":"Brubakk AO","year":"2003","edition":"4"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61085-9"},{"key":"e_1_3_6_6_2","first-page":"162","article-title":"The role of intra-vascular bubbles and the vascular endothelium in decompression sickness","volume":"39","author":"Brubakk AO","year":"2009","journal-title":"Diving Hyperb. 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