{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:00:30Z","timestamp":1791910830446,"version":"4.3.4"},"reference-count":26,"publisher":"The Royal Society","issue":"162","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"crossref","award":["Ambizione - PZ00P2_174113"],"award-info":[{"award-number":["Ambizione - PZ00P2_174113"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    The purpose of this study was to develop a novel non-contact optical coherence elastography (OCE) approach to measure laterally and axially highly resolved corneal strain distribution at different stages of patterned corneal cross-linking (CXL). Freshly enucleated rat eyes were obtained and prepared for accelerated patterned CXL treatment with distinct ultraviolet (UV) patterns (central, peripheral, bow-tie irradiation). Each cornea was measured repeatedly, in three different conditions: (i) virgin, (ii) after epithelial debridement and 0.5% hypo-osmolar riboflavin instillation for 30 min, and (iii) after patterned CXL at 9 mW cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    for 10 min. For biomechanical assessment, the corneal deformation response to an ambient pressure variation of \u22122 mmHg was recorded by OCE. Strain maps were obtained from phase and magnitude changes in the complex optical coherence tomography signal. Virgin corneas presented negative strain (\u22122.7 \u00b1 1.1\u2030) in the anterior cornea and positive strain (1.9 \u00b1 1.3\u2030) in the posterior cornea. A pronounced shift towards positive strains in the anterior cornea (particularly in UV-irradiated regions) was observed after CXL. Patterned UV irradiation induced localized strain alterations closely matching the geometry of the irradiation pattern. This study demonstrates the possibility of non-contact OCE by ambient pressure modulation, which could substantially improve the early diagnosis of corneal degeneration, advance research in small-animal eyes and refine\n                    <jats:italic>in vitro<\/jats:italic>\n                    mechanical investigation.\n                  <\/jats:p>","DOI":"10.1098\/rsif.2019.0786","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T03:06:29Z","timestamp":1579662389000},"page":"20190786","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":40,"title":["Optical coherence elastography by ambient pressure modulation for high-resolution strain mapping applied to patterned cross-linking"],"prefix":"10.1098","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-7200","authenticated-orcid":true,"given":"Sabine","family":"Kling","sequence":"first","affiliation":[{"name":"O.P.T.I.C. Team, Computer-Assisted Applications in Medicine Group, Computer Vision Laboratory, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2014.5641"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(80)80027-3"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20160629-01"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14450"},{"key":"e_1_3_5_6_2","first-page":"1288","article-title":"Optical coherence elastography based corneal strain mapping during low-amplitude intraocular pressure modulation","volume":"60","author":"Kling S","year":"2019","journal-title":"Invest. Ophthalmol. Vis. 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In press. Optical coherence elastography based corneal strain imaging during low-amplitude intraocular pressure modulation. Front. Bioeng. 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