{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:56:43Z","timestamp":1789073803474,"version":"build-2803163510"},"reference-count":59,"publisher":"The Royal Society","issue":"185","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001634","name":"National University of Ireland Galway","doi-asserted-by":"crossref","award":["College of Medicine, Nursing and Health Sciences"],"award-info":[{"award-number":["College of Medicine, Nursing and Health Sciences"]}],"id":[{"id":"10.13039\/501100001634","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"crossref","award":["DELIVER project 812865"],"award-info":[{"award-number":["DELIVER project 812865"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"crossref","award":["SFI\/12\/RC\/2278 AMBER Centre"],"award-info":[{"award-number":["SFI\/12\/RC\/2278 AMBER Centre"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"crossref","award":["URF\\R1\\191335 Royal Society URF"],"award-info":[{"award-number":["URF\\R1\\191335 Royal Society URF"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Delivering a clinically impactful cell number is a major design challenge for cell macroencapsulation devices for Type 1 diabetes. It is important to understand the transplant site anatomy to design a device that is practical and that can achieve a sufficient cell dose. We identify the posterior rectus sheath plane as a potential implant site as it is easily accessible, can facilitate longitudinal monitoring of transplants, and can provide nutritive support for cell survival. We have investigated this space using morphomics across a representative patient cohort (642 participants) and have analysed the data in terms of gender, age and BMI. We used a shape optimization process to maximize the volume and identified that elliptical devices achieve a clinically impactful cell dose while meeting device manufacture and delivery requirements. This morphomics framework has the potential to significantly influence the design of future macroencapsulation devices to better suit the needs of patients.<\/jats:p>","DOI":"10.1098\/rsif.2021.0673","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T19:09:44Z","timestamp":1640113784000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Developing a morphomics framework to optimize implant site-specific design parameters for islet macroencapsulation devices"],"prefix":"10.1098","volume":"18","author":[{"given":"Barry","family":"McDermott","sequence":"first","affiliation":[{"name":"Translational Medical Device Lab, College of Medicine Nursing and Health Sciences, National University of Ireland (NUI) Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Robinson","sequence":"additional","affiliation":[{"name":"Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland (NUI) Galway, Galway, Ireland"},{"name":"Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA"},{"name":"Advanced Materials and BioEngineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Holcombe","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E.","family":"Levey","sequence":"additional","affiliation":[{"name":"Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland (NUI) Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dockery","sequence":"additional","affiliation":[{"name":"Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland (NUI) Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Johnson","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences and NIHR Biomedical Research Centre, Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Wang","sequence":"additional","affiliation":[{"name":"Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6742-8461","authenticated-orcid":true,"given":"Eimear B.","family":"Dolan","sequence":"additional","affiliation":[{"name":"Biomedical Engineering, School of Engineering, College of Science and Engineering, National University of Ireland (NUI) Galway, Galway, Ireland"},{"name":"CURAM, Centre for Research in Medical Devices, National University of Ireland (NUI) Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry P.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland (NUI) Galway, Galway, Ireland"},{"name":"CURAM, Centre for Research in Medical Devices, National University of Ireland (NUI) Galway, Galway, Ireland"},{"name":"Advanced Materials and BioEngineering Research Centre (AMBER), Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0088-0"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2012.9.385"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007273430401"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.178"},{"key":"e_1_3_6_6_2","unstructured":"CITR. 2017 Tenth Annual Report. Collaborative Islet Transplant Registry."},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0401"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/db20-116-OR"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199503000-00003"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.3.557"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.891"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1104649"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12919"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100820"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2101258118"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14642"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb4601"},{"key":"e_1_3_6_18_2","first-page":"e2132","article-title":"Subcutaneous clinical islet transplantation in a prevascularized subcutaneous pouch\u2014preliminary experience","volume":"4","author":"Gala-Lopez B","year":"2016","unstructured":"Gala-Lopez B, Pepper A, Dinyari P, Malcolm A, Kin T, Pawlick L, Senior PA, Shapiro AM. 2016 Subcutaneous clinical islet transplantation in a prevascularized subcutaneous pouch\u2014preliminary experience. Cell 4, e2132.","journal-title":"Cell"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708806115"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1711"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108067"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0430-6"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax9106"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3033"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/096368970000900114"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v6.i1.69"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120499"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.04.018"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/2041731420924818"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2014.11.84"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02489.x"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)02381-X"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.01.011"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/0963689720952343"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael143"},{"key":"e_1_3_6_36_2","unstructured":"Sevensma KE Pihl KD. 2018 Anatomy abdomen and pelvis rectus sheath. Treasure Island FL: StatPearls Publishing."},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200202000-00020"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.1.12"},{"key":"e_1_3_6_39_2","volume-title":"Machine learning","author":"Mitchell TM","year":"1997","unstructured":"Mitchell TM. 1997 Machine learning. New York, NY: McGraw Hill."},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02581331"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)75732-3"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23862-w"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/bit.20722"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608141103"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00202"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.03.056"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002247"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1005-5"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.612604"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-018-1434-9"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0522"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000305"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aax7043"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0169-1"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0247-5"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2021.0163"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100229"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13122077"},{"key":"e_1_3_6_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-017-0983-3"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29825-5"}],"container-title":["Journal of The Royal Society Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2021.0673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsif.2021.0673","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2021.0673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:20:59Z","timestamp":1778620859000},"score":1,"resource":{"primary":{"URL":"http:\/\/royalsocietypublishing.org\/rsif\/article\/90149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":59,"journal-issue":{"issue":"185","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1098\/rsif.2021.0673"],"URL":"https:\/\/doi.org\/10.1098\/rsif.2021.0673","relation":{},"ISSN":["1742-5662"],"issn-type":[{"value":"1742-5662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"20210673"}}