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Interface."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries to percutaneous transluminal angioplasty and stent deployment, leading to lumen re-narrowing as consequence of excessive cellular proliferative and synthetic activities. A thorough understanding of the underlying mechanobiological factors contributing to ISR is still lacking. Computational multiscale models integrating both continuous- and agent-based approaches have been identified as promising tools to capture key aspects of the complex network of events encompassing molecular, cellular and tissue response to the intervention. In this regard, this work presents a multiscale framework integrating the effects of local haemodynamics and monocyte gene expression data on cellular dynamics to simulate ISR mechanobiological processes in a patient-specific model of stented superficial femoral artery. The framework is based on the coupling of computational fluid dynamics simulations (haemodynamics module) with an agent-based model (ABM) of cellular activities (tissue remodelling module). Sensitivity analysis and surrogate modelling combined with genetic algorithm optimization were adopted to explore the model behaviour and calibrate the ABM parameters. The proposed framework successfully described the patient lumen area reduction from baseline to one-month follow-up, demonstrating the potential capabilities of this approach in predicting the short-term arterial response to the endovascular procedure.<\/jats:p>","DOI":"10.1098\/rsif.2021.0871","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T07:06:30Z","timestamp":1648623990000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics"],"prefix":"10.1098","volume":"19","author":[{"given":"Anna","family":"Corti","sequence":"first","affiliation":[{"name":"LaBS, Department of Chemistry, Materials and Chemical Engineering \u2018Giulio Natta\u2019, Politecnico di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Colombo","sequence":"additional","affiliation":[{"name":"LaBS, Department of Chemistry, Materials and Chemical Engineering \u2018Giulio Natta\u2019, Politecnico di Milano, Milan, Italy"},{"name":"Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"Rozowsky","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Casarin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Houston Methodist Hospital, Houston, TX, USA"},{"name":"Center for Computational Surgery, Houston Methodist Research Institute, Houston, TX, USA"},{"name":"Houston Methodist Academic Institute, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Carbonaro","sequence":"additional","affiliation":[{"name":"PoliToBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Migliavacca","sequence":"additional","affiliation":[{"name":"LaBS, Department of Chemistry, Materials and Chemical Engineering \u2018Giulio Natta\u2019, Politecnico di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose F.","family":"Rodriguez Matas","sequence":"additional","affiliation":[{"name":"LaBS, Department of Chemistry, Materials and Chemical Engineering \u2018Giulio Natta\u2019, Politecnico di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Berceli","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Florida, Gainesville, FL, USA"},{"name":"Malcom Randall VAMC, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-6142","authenticated-orcid":true,"given":"Claudio","family":"Chiastra","sequence":"additional","affiliation":[{"name":"LaBS, Department of Chemistry, Materials and Chemical Engineering \u2018Giulio Natta\u2019, Politecnico di Milano, Milan, Italy"},{"name":"PoliToBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30255-4"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340309789317823"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-014-0876-3"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt115"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2018.0074"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.744560"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2019.0313"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2021.0068"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094411"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(07)71003-6"},{"key":"e_1_3_6_12_2","doi-asserted-by":"crossref","unstructured":"DeSart K O'Malley K Schmit B Lopez MC Moldawer L Baker H Berceli S Nelson P. 2016 Systemic inflammation as a predictor of clinical outcomes after lower extremity angioplasty\/stenting. 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