{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:47:46Z","timestamp":1787010466168,"version":"build-2736575974"},"reference-count":44,"publisher":"The Royal Society","issue":"192","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"crossref","award":["G2021005F"],"award-info":[{"award-number":["G2021005F"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008065","name":"Georgia Research Alliance","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH-NEI","award":["R01 EY031710"],"award-info":[{"award-number":["R01 EY031710"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>\n                    The iris is a muscular organ whose deformations can cause primary angle-closure glaucoma (PACG), a leading cause of blindness. PACG risk assessment does not consider iridial biomechanical factors, despite their expected influence on iris deformations. Here, we exploited an existing biometric dataset consisting of near-infrared movies acquired during the pupillary light reflex (PLR) as a unique resource to study iris biomechanics. The PLR caused significant (greater than 100%) and essentially spatially uniform radial strains in the iris\n                    <jats:italic>in vivo<\/jats:italic>\n                    , consistent with previous findings. Inverse finite-element modelling showed that sphincter muscle tractions were\n                    <jats:italic>ca<\/jats:italic>\n                    fivefold greater than iridial stroma stiffness (range 4- to 13-fold, depending on sphincter muscle size). This muscle traction is greater than has been previously estimated, which may be due to methodological differences and\/or to different patient populations in our study (European descent) versus previous studies (Asian); the latter possibility is of particular interest due to differential incidence rates of PACG in these populations. Our methodology is fast and inexpensive and may be a useful tool in understanding biomechanical factors contributing to PACG.\n                  <\/jats:p>","DOI":"10.1098\/rsif.2022.0108","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T03:24:56Z","timestamp":1657077896000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>In vivo<\/i>\n                    biomechanical assessment of iridial deformations and muscle contractions in human eyes"],"prefix":"10.1098","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-2870","authenticated-orcid":true,"given":"Babak N.","family":"Safa","sequence":"first","affiliation":[{"name":"Wallace H. 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