{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:00:44Z","timestamp":1791475244805,"version":"4.3.4"},"reference-count":49,"publisher":"The Royal Society","issue":"198","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["17H02075"],"award-info":[{"award-number":["17H02075"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["19K20672"],"award-info":[{"award-number":["19K20672"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["21H05785"],"award-info":[{"award-number":["21H05785"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>The amplitude and frequency of peristaltic contractions are two major parameters for assessing gastric motility. However, it is not fully understood how these parameters affect the important functions of the stomach, such as gastric mixing and emptying. This study aimed to quantify the effects of peristaltic amplitude and frequency on gastric mixing and emptying using computational fluid dynamics simulation of gastric flow with an anatomically realistic model of the stomach. Our results suggest that both the increase and decrease in peristaltic amplitude have a significant impact on mixing strength and emptying rate. For example, when the peristaltic amplitude was 1.2 times higher than normal, the emptying rate was 2.7 times faster, whereas when the amplitude was half, the emptying rate was 4.2 times slower. Moreover, the emptying rate increased more than proportionally with the peristaltic frequency. The nearest contraction wave to the pylorus and the subsequent waves promoted gastric emptying. These results suggest the importance of maintaining parameters within normal ranges to achieve healthy gastric function.<\/jats:p>","DOI":"10.1098\/rsif.2022.0780","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:05:31Z","timestamp":1672790731000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of peristaltic amplitude and frequency on gastric emptying and mixing: a simulation study"],"prefix":"10.1098","volume":"20","author":[{"given":"Rika","family":"Ebara","sequence":"first","affiliation":[{"name":"Graduate School of Engineering, Kobe University, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-3429","authenticated-orcid":false,"given":"Shunichi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering, Kobe University, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-1044","authenticated-orcid":false,"given":"Taimei","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4856-3799","authenticated-orcid":true,"given":"Yohsuke","family":"Imai","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering, Kobe University, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2007.04.001"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13546"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.5122665"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05018.x"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-014-4007-9"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00396.x"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01710.x"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1999.0029900453"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087897"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2004.2886"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.6.G1370"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2016.16281"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.038588"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018826719628"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14151"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005493123557"},{"key":"e_1_3_6_18_2","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman DA","year":"2006","unstructured":"Drossman DA, Dumitrascu DL. 2006 Rome III: new standard for functional gastrointestinal disorders. J. Gastrointestin. Liver Dis. 15, 237.","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318712"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-002-0023-0"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i5.673"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02300384"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2006.06.006"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2010.01748.x"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11483-010-9183-y"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01226H"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00350.2012"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00255.2016"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00346.2016"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2019.0266"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14659"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2004.02.003"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.1996.96236280"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.4.G604"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2020.110461"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02239239"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.camwa.2015.05.001"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.65.041203"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.6.G1227"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00524.x"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2586(200008)12:2<343::AID-JMRI18>3.0.CO;2-M"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1990.tb00015.x"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13988"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01008.x"},{"key":"e_1_3_6_45_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2982.2009.01365.x","article-title":"Association of the status of interstitial cells of Cajal and electrogastrogram parameters, gastric emptying and symptoms in patients with gastroparesis","volume":"22","author":"Lin Z","year":"2010","unstructured":"Lin Z, Sarosiek I, Forster J, Damjanov I, Hou Q, McCallum R. 2010 Association of the status of interstitial cells of Cajal and electrogastrogram parameters, gastric emptying and symptoms in patients with gastroparesis. Neurogastroenterol. Motil. 22, 56-e10. (doi:10.1111\/j.1365-2982.2009.01365.x)","journal-title":"Neurogastroenterol. Motil."},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.7.799"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02441653"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02064998"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13152"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/282757"}],"container-title":["Journal of The Royal Society Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2022.0780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsif.2022.0780","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsif.2022.0780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:04:11Z","timestamp":1701648251000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsif.2022.0780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":49,"journal-issue":{"issue":"198","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1098\/rsif.2022.0780"],"URL":"https:\/\/doi.org\/10.1098\/rsif.2022.0780","relation":{},"ISSN":["1742-5662"],"issn-type":[{"value":"1742-5662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"20220780"}}