{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:37:03Z","timestamp":1757626623880,"version":"3.44.0"},"reference-count":55,"publisher":"The Royal Society","issue":"230","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/-\/media\/journals\/author\/Licence-to-Publish-20062019-final.pdf"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["J. R. Soc. Interface."],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n            Severe fever with thrombocytopaenia syndrome virus (SFTSV) was identified by the World Health Organization as a priority pathogen due to its high case-fatality rate in humans and rapid spread. It is maintained in nature through three transmission pathways: systemic, non-systemic and transovarial. Understanding the relative contributions of these transmission pathways is crucial for developing evidence-informed public health interventions to reduce its spillover risks to humans. Using next-generation matrices, sensitivity analyses, elasticity analyses and random forest models, we estimated the basic reproduction number\n            <jats:italic toggle=\"yes\">R<\/jats:italic>\n            <jats:sub>0<\/jats:sub>\n            , relative contribution of each pathway, and identified the most sensitive model parameters across 27 scenarios. Results showed that\n            <jats:inline-formula>\n              <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                <mml:msub>\n                  <mml:mrow>\n                    <mml:mi>R<\/mml:mi>\n                  <\/mml:mrow>\n                  <mml:mrow>\n                    <mml:mn>0<\/mml:mn>\n                  <\/mml:mrow>\n                <\/mml:msub>\n              <\/mml:math>\n            <\/jats:inline-formula>\n            ranged from 0.72 to 2.08 across scenarios, increasing with higher tick abundance and longer viraemia. Transovarial transmission dominated in 26 scenarios, while the importance of the other two varied, with non-systemic transmission more important under high tick abundance, short viraemia or aggregated tick distribution.\n            <jats:inline-formula>\n              <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                <mml:msub>\n                  <mml:mrow>\n                    <mml:mi>R<\/mml:mi>\n                  <\/mml:mrow>\n                  <mml:mrow>\n                    <mml:mn>0<\/mml:mn>\n                  <\/mml:mrow>\n                <\/mml:msub>\n              <\/mml:math>\n            <\/jats:inline-formula>\n            dropped below 1 in all scenarios when transovarial transmission was excluded. These findings emphasize the need for interventions targeting transovarial transmission, such as reducing female adult tick survival and limiting large vertebrate host movement, and underscore the importance of laboratory studies measuring sensitive parameters including transovarial transmission efficiency, tick survival probabilities and the duration of viraemia and potential for non-systemic transmission for key animal host species with high seroprevalence rates.\n          <\/jats:p>","DOI":"10.1098\/rsif.2025.0140","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T23:06:03Z","timestamp":1757459163000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the relative roles of systemic, non-systemic and transovarial transmission pathways for severe fever with thrombocytopaenia syndrome virus and its implications for future research and intervention strategies"],"prefix":"10.1098","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-9218","authenticated-orcid":true,"given":"Qu","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Hassall","sequence":"additional","affiliation":[{"name":"UK Centre for Ecology & Hydrology","place":["Wallingford, UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering, Huazhong University of Science and Technology","place":["Wuhan, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Nanjing Medical University","place":["Nanjing, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-8170","authenticated-orcid":true,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology","place":["Beijing, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Qun","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology","place":["Beijing, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Georgia","place":["Athens, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethan V.","family":"Purse","sequence":"additional","affiliation":[{"name":"UK Centre for Ecology & Hydrology","place":["Wallingford, UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_3_8_2_2","first-page":"101133","article-title":"Global epidemiology of severe fever with thrombocytopenia syndrome virus in human and animals: a systematic review and meta-analysis","volume":"48","author":"Cui H","year":"2024","unstructured":"Cui H et al. 2024 Global epidemiology of severe fever with thrombocytopenia syndrome virus in human and animals: a systematic review and meta-analysis. 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