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R. Soc. Interface."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Keratoconus (KC) is a progressive corneal ectasia leading to visual impairment if untreated. Corneal collagen cross-linking (CXL) is an effective treatment to halt KC progression by strengthening corneal biomechanics. However, current CXL treatments lack customization based on regional corneal stiffness, which is crucial for optimal outcomes. This study introduces a novel approach using Stress\u2013Strain Index (SSI) maps to evaluate localized CXL effects on corneal biomechanics. Numerical modelling based on the finite element method was used to carry out inverse analysis of the human eye to simulate KC and CXL treatments, incorporating regional stiffness variations based on collagen fibril density. SSI maps were generated pre- and post-CXL to assess stiffness changes in treated regions. 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