{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:13:14Z","timestamp":1792595594777,"version":"4.5.0"},"reference-count":77,"publisher":"The Royal Society","issue":"239","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Almost half of the world's population is at risk of acquiring dengue virus (DENV) each year. However, no specific licensed prophylactic or antiviral treatment for dengue currently exists. Mosnodenvir, a novel DENV inhibitor, has been shown to inhibit DENV replication in vitro and in animal studies. Here, we provide new insights into the in vivo prophylactic inhibitory effect of mosnodenvir exposure on primary DENV-2 infection by fitting mechanistic within-host models of DENV infection to virological and serological data observed from pre-clinical challenge studies in AG129 mice and rhesus macaques. We estimated a median mosnodenvir concentration achieving 50% of maximal inhibitory effect (IC50) on viral replication of 8.35 (6.82, 9.22) ng ml\u22121 and 7.61 (5.67, 8.92) ng ml\u22121 for AG129 mice and rhesus macaques, respectively. A higher concentration is typically required to suppress viral replication in AG129 mice compared with rhesus macaques owing to a higher estimated within-host basic reproduction number (R0) in mice. By integrating multiple data types in a single framework, this study enhances our understanding of the within-host dynamics of primary DENV infection in non-human host species. Furthermore, the methods developed here could possibly assist in quantifying the prophylactic inhibitory effect of mosnodenvir on DENV infections in humans.<\/jats:p>","DOI":"10.1098\/rsif.2025.1018","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:02:32Z","timestamp":1781078552000},"source":"Crossref","is-referenced-by-count":3,"title":["Estimating the\n                    <i>in vivo<\/i>\n                    prophylactic effect of mosnodenvir, a novel dengue antiviral, on DENV-2 infection"],"prefix":"10.1098","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-8401","authenticated-orcid":true,"given":"Clare","family":"McCormack","sequence":"first","affiliation":[{"name":"MRC Centre for Global Infectious Disease Analysis, Imperial College London 1 , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Goethals","sequence":"additional","affiliation":[{"name":"Johnson and Johnson Pharmaceutical Research and Development Belgium 2 , Beerse, Flanders, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-5318","authenticated-orcid":true,"given":"Nele","family":"Goeyvaerts","sequence":"additional","affiliation":[{"name":"Johnson and Johnson Pharmaceutical Research and Development Belgium 2 , Beerse, Flanders, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier Woot","family":"De Trixhe","sequence":"additional","affiliation":[{"name":"Johnson and Johnson Pharmaceutical Research and Development Belgium 2 , Beerse, Flanders, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babs","family":"Verstrepen","sequence":"additional","affiliation":[{"name":"Biomedical Primate Research Centre 3 , Rijswijk, ZH, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"van Wesenbeek","sequence":"additional","affiliation":[{"name":"Johnson and Johnson Pharmaceutical Research and Development Belgium 2 , Beerse, Flanders, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst","family":"Verschoor","sequence":"additional","affiliation":[{"name":"Biomedical Primate Research Centre 3 , Rijswijk, ZH, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne J.","family":"Kaptein","sequence":"additional","affiliation":[{"name":"Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute of Medical Research 4 , KU, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[{"name":"Virology, Antiviral Drug & Vaccine Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute of Medical Research 4 , KU, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnix","family":"Van Loock","sequence":"additional","affiliation":[{"name":"Johnson and Johnson Pharmaceutical Research and Development Belgium 2 , Beerse, Flanders, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Ferguson","sequence":"additional","affiliation":[{"name":"MRC Centre for Global Infectious Disease Analysis, Imperial College London 1 , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Ackaert","sequence":"additional","affiliation":[{"name":"Johnson and Johnson Pharmaceutical Research and Development Belgium 2 , Beerse, Flanders, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Dorigatti","sequence":"additional","affiliation":[{"name":"MRC Centre for Global Infectious Disease Analysis, Imperial College London 1 , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"2026082409475336400_RSIF20251018C1","doi-asserted-by":"crossref","first-page":"eaax4144","DOI":"10.1126\/scitranslmed.aax4144","article-title":"Mapping global variation in dengue transmission intensity","volume":"12","author":"Cattarino","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"2026082409475336400_RSIF20251018C2","article-title":"Global strategy for dengue prevention and control 2012\u20132020","author":"World Health Organization","year":"2012"},{"key":"2026082409475336400_RSIF20251018C3","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.2149\/tmh.2011-S05","article-title":"Dengue, urbanization and globalization: the unholy trinity of the 21st century","volume":"39","author":"Gubler","year":"2011","journal-title":"Trop. Med. Health"},{"key":"2026082409475336400_RSIF20251018C4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tim.2013.12.011","article-title":"Global spread of dengue virus types: mapping the 70 year history","volume":"22","author":"Messina","year":"2014","journal-title":"Trends Microbiol."},{"key":"2026082409475336400_RSIF20251018C5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue","volume":"393","author":"Wilder-Smith","year":"2019","journal-title":"Lancet"},{"key":"2026082409475336400_RSIF20251018C6","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"Simmons","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"2026082409475336400_RSIF20251018C7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coviro.2020.07.009","article-title":"Recent advances in antiviral drug development towards dengue virus","volume":"43","author":"Troost","year":"2020","journal-title":"Curr. Opin. Virol."},{"key":"2026082409475336400_RSIF20251018C8","article-title":"Dengue: current state one year before WHO 2010\u20132020 goals","author":"Wellekens","year":"2020","journal-title":"Acta Clin. Belgica Int. J. Clin. Lab. Med."},{"key":"2026082409475336400_RSIF20251018C9","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1093\/infdis\/jiw423","article-title":"Current status of dengue therapeutics research and development","volume":"215","author":"Low","year":"2017","journal-title":"J. Infect. Dis."},{"key":"2026082409475336400_RSIF20251018C10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.antiviral.2018.12.016","article-title":"Dengue drug discovery: progress, challenges and outlook","volume":"163","author":"Lim","year":"2019","journal-title":"Antiviral Res."},{"key":"2026082409475336400_RSIF20251018C11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2016.06.002","article-title":"Towards antiviral therapies for treating dengue virus infections","volume":"30","author":"Kaptein","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"2026082409475336400_RSIF20251018C12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/QCO.0000000000000871","article-title":"Dengue vaccine development: challenges and prospects","volume":"35","author":"Wilder-Smith","year":"2022","journal-title":"Curr. Opin. Infect. Dis."},{"key":"2026082409475336400_RSIF20251018C13","first-page":"1","author":"World Health Organization.","year":"2024","journal-title":"Vaccines and immunization: dengue"},{"key":"2026082409475336400_RSIF20251018C14","volume-title":"New dengue vaccine approved in Indonesia for use regardless of prior dengue exposure","author":"Takeda","year":"2022"},{"key":"2026082409475336400_RSIF20251018C15","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1016\/S1473-3099(26)00013-7","article-title":"Brazil approves domestic single-shot dengue vaccine","volume":"26","author":"Triunfol","year":"2026","journal-title":"Lancet Infect. Dis."},{"key":"2026082409475336400_RSIF20251018C16","volume-title":"WHO position paper on dengue vaccines","author":"World Health Organization","year":"2024"},{"key":"2026082409475336400_RSIF20251018C17","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1038\/s41591-025-03771-y","article-title":"Efficacy, public health impact and optimal use of the Takeda dengue vaccine","volume":"31","author":"Cracknell Daniels","year":"2025","journal-title":"Nat. Med."},{"key":"2026082409475336400_RSIF20251018C18","first-page":"619","article-title":"Effectiveness of peridomestic space spraying with insecticide on dengue transmission; systematic review","volume":"15","author":"Esu","year":"2010","journal-title":"Trop. Med. Int. Heal."},{"key":"2026082409475336400_RSIF20251018C19","doi-asserted-by":"crossref","first-page":"e0003655","DOI":"10.1371\/journal.pntd.0003655","article-title":"A critical assessment of vector control for dengue prevention","volume":"9","author":"Achee","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2026082409475336400_RSIF20251018C20","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41586-018-0318-5","article-title":"Challenges and opportunities in controlling mosquito-borne infections","volume":"559","author":"Ferguson","year":"2018","journal-title":"Nature"},{"key":"2026082409475336400_RSIF20251018C21","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.antiviral.2009.12.011","article-title":"Strategies for development of dengue virus inhibitors","volume":"85","author":"Noble","year":"2010","journal-title":"Antiviral Res."},{"key":"2026082409475336400_RSIF20251018C22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2016.06.002","article-title":"Towards antiviral therapies for treating dengue virus infections","volume":"30","author":"Kaptein","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"2026082409475336400_RSIF20251018C23","first-page":"333","article-title":"An industry perspective on dengue drug discovery and development","volume-title":"Advances in experimental medicine and biology","author":"Hernandez-Morales","year":"2018"},{"key":"2026082409475336400_RSIF20251018C24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3390\/v6020683","article-title":"Targeting host factors to treat West Nile and dengue viral infections","volume":"6","author":"Krishnan","year":"2014","journal-title":"Viruses"},{"key":"2026082409475336400_RSIF20251018C25","doi-asserted-by":"crossref","first-page":"105517","DOI":"10.1016\/j.antiviral.2022.105517","article-title":"Therapeutics for flaviviral infections","volume":"210","author":"Bifani","year":"2023","journal-title":"Antiviral Res."},{"key":"2026082409475336400_RSIF20251018C26","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1086\/340365","article-title":"Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections","volume":"185","author":"Libraty","year":"2002","journal-title":"J. Infect. Dis."},{"key":"2026082409475336400_RSIF20251018C27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J. Infect. Dis."},{"key":"2026082409475336400_RSIF20251018C28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rmv.2121","article-title":"The association between dengue viremia kinetics and dengue severity: a systemic review and meta-analysis","volume":"30","author":"Morsy","year":"2020","journal-title":"Rev. Med. Virol."},{"key":"2026082409475336400_RSIF20251018C29","doi-asserted-by":"crossref","first-page":"9072","DOI":"10.1073\/pnas.1303395110","article-title":"Host and viral features of human dengue cases shape the population of infected and infectious Aedesaegypti mosquitoes","volume":"110","author":"Nguyen","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026082409475336400_RSIF20251018C30","first-page":"290","article-title":"Human to mosquito transmission of dengue viruses","volume-title":"Front. Immunol.","author":"Carrington","year":"2014"},{"key":"2026082409475336400_RSIF20251018C31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41586-023-05790-6","article-title":"Blocking NS3\u2013NS4B interaction inhibits dengue virus in non-human primates","volume":"615","author":"Goethals","year":"2023","journal-title":"Nature"},{"key":"2026082409475336400_RSIF20251018C32","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41586-021-03990-6","article-title":"A pan-serotype dengue virus\u00a0inhibitor targeting the NS3\u2013NS4B\u00a0interaction","volume":"598","author":"Kaptein","year":"2021","journal-title":"Nature"},{"key":"2026082409475336400_RSIF20251018C33","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1021\/acs.jmedchem.3c02336","article-title":"Discovery of JNJ-1802, a first-in-class pan-serotype dengue virus NS4B inhibitor","volume":"67","author":"Kesteleyn","year":"2024","journal-title":"J. Med. Chem."},{"key":"2026082409475336400_RSIF20251018C34","doi-asserted-by":"crossref","first-page":"e1011662","DOI":"10.1371\/journal.pcbi.1011662","article-title":"Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics","volume":"19","author":"McCormack","year":"2023","journal-title":"PLoS Comput. Biol."},{"key":"2026082409475336400_RSIF20251018C35","volume-title":"Johnson & Johnson to discontinue phase 2 field study evaluating investigational antiviral for the prevention of dengue","author":"Johnson & Johnson","year":"2024"},{"key":"2026082409475336400_RSIF20251018C36","doi-asserted-by":"crossref","first-page":"20140094","DOI":"10.1098\/rsif.2014.0094","article-title":"Within-host viral dynamics of dengue serotype 1 infection","volume":"11","author":"Clapham","year":"2014","journal-title":"J. R. Soc. Interface"},{"key":"2026082409475336400_RSIF20251018C37","doi-asserted-by":"crossref","first-page":"e1004951","DOI":"10.1371\/journal.pcbi.1004951","article-title":"Modelling virus and antibody dynamics during dengue virus infection suggests a role for antibody in virus clearance","volume":"12","author":"Clapham","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"2026082409475336400_RSIF20251018C38","doi-asserted-by":"crossref","first-page":"20140886","DOI":"10.1098\/rsif.2014.0886","article-title":"Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections","volume":"12","author":"Ben-Shachar","year":"2015","journal-title":"J. R. Soc. Interface"},{"key":"2026082409475336400_RSIF20251018C39","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.mcm.2008.06.016","article-title":"A with-in host dengue infection model with immune response","volume":"49","author":"Nuraini","year":"2009","journal-title":"Math. Comput. Model."},{"key":"2026082409475336400_RSIF20251018C40","doi-asserted-by":"crossref","first-page":"1005194","DOI":"10.1371\/journal.pcbi.1005194","article-title":"Drivers of inter-individual variation in dengue viral load dynamics","volume":"12","author":"Ben-Shachar","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"2026082409475336400_RSIF20251018C41","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1038\/s41467-018-04595-w","article-title":"Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context","volume":"9","author":"Ben-Shachar","year":"2018","journal-title":"Nat. Commun."},{"key":"2026082409475336400_RSIF20251018C42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1741-7007-11-96","article-title":"Modeling the within-host dynamics of HIV infection","volume":"11","author":"Perelson","year":"2013","journal-title":"BMC Biol."},{"key":"2026082409475336400_RSIF20251018C43","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1098\/rspb.2012.0595","article-title":"New insights into the evolutionary rate of HIV-1 at the within-host and epidemiological levels","volume":"279","author":"Lythgoe","year":"2012","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"2026082409475336400_RSIF20251018C44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.282.5386.103","article-title":"Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-\u03b1 therapy","volume":"282","author":"Neumann","year":"1998","journal-title":"Science"},{"key":"2026082409475336400_RSIF20251018C45","doi-asserted-by":"crossref","first-page":"e1002588","DOI":"10.1371\/journal.pcbi.1002588","article-title":"Modeling within-host dynamics of influenza virus infection including immune responses","volume":"8","author":"Pawelek","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"2026082409475336400_RSIF20251018C46","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1471-2458-11-S1-S7","article-title":"A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead","volume":"11","author":"Beauchemin","year":"2011","journal-title":"BMC Public Health"},{"key":"2026082409475336400_RSIF20251018C47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1098\/rsif.2009.0067","article-title":"Towards a quantitative understanding of the within-host dynamics of influenza A infections","volume":"7","author":"Handel","year":"2009","journal-title":"J. R. Soc. Interface"},{"key":"2026082409475336400_RSIF20251018C48","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/wsbm.129","article-title":"Influenza a virus infection kinetics: quantitative data and models","volume":"3","author":"Smith","year":"2011","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"2026082409475336400_RSIF20251018C49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10928-010-9151-7","article-title":"Basic PK\/PD principles of drug effects in circular\/proliferative systems for disease modelling","volume":"37","author":"Jacqmin","year":"2010","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"2026082409475336400_RSIF20251018C50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.virol.2014.01.015","article-title":"Viral kinetics of primary dengue virus infection in non-human primates: A systematic review and individual pooled analysis","volume":"452\u2013453","author":"Althouse","year":"2014","journal-title":"Virology"},{"key":"2026082409475336400_RSIF20251018C51","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/v4010062","article-title":"Animal models of dengue virus infection","volume":"4","author":"Zompi","year":"2012","journal-title":"Viruses"},{"key":"2026082409475336400_RSIF20251018C52","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/JVI.73.1.783-786.1999","article-title":"New mouse model for dengue virus vaccine testing","volume":"73","author":"Johnson","year":"1999","journal-title":"J. Virol."},{"key":"2026082409475336400_RSIF20251018C53","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1111\/j.1749-6632.2009.05057.x","article-title":"A mouse model for studying dengue virus pathogenesis and immune response","volume":"1171","author":"Williams","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2026082409475336400_RSIF20251018C54","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.virol.2008.08.008","article-title":"Antibodies play a greater role than immune cells in heterologous protection against secondary dengue virus infection in a mouse model","volume":"380","author":"Kyle","year":"2008","journal-title":"Virology"},{"key":"2026082409475336400_RSIF20251018C55","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1086\/511310","article-title":"A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs","volume":"195","author":"Schul","year":"2007","journal-title":"J. Infect. Dis."},{"key":"2026082409475336400_RSIF20251018C56","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1128\/CVI.00052-07","article-title":"Transcriptional activation of interferon-stimulated genes but not of cytokine genes after primary infection of rhesus macaques with dengue virus type 1","volume":"14","author":"Sariol","year":"2007","journal-title":"Clin. Vaccine Immunol."},{"key":"2026082409475336400_RSIF20251018C57","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.micinf.2007.03.012","article-title":"Characterization of humoral and cellular immune responses in cynomolgus macaques upon primary and subsequent heterologous infections with dengue viruses","volume":"9","author":"Koraka","journal-title":"Microbes Infect."},{"key":"2026082409475336400_RSIF20251018C58","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1086\/427511","article-title":"Cross-serotype neutralization of dengue virus in Aotusnancymae monkeys","volume":"191","author":"Kochel","year":"2005","journal-title":"J. Infect. Dis."},{"key":"2026082409475336400_RSIF20251018C59","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.meegid.2013.03.008","article-title":"Fever versus fever: the role of host and vector susceptibility and interspecific competition in shaping the current and future distributions of the sylvatic cycles of dengue virus and yellow fever virus","volume":"19","author":"Hanley","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"2026082409475336400_RSIF20251018C60","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3389\/fmicb.2013.00305","article-title":"Can non-human primates serve as models for investigating dengue disease pathogenesis?","volume":"4","author":"Clark","year":"2013","journal-title":"Front. Microbiol."},{"key":"2026082409475336400_RSIF20251018C61","doi-asserted-by":"crossref","first-page":"93229","DOI":"10.3389\/fimmu.2014.00452","article-title":"Utility, limitations, and future of non-human primates for dengue research and vaccine development","volume":"5","author":"Sariol","year":"2014","journal-title":"Front. Immunol."},{"key":"2026082409475336400_RSIF20251018C62","doi-asserted-by":"crossref","first-page":"e68864","DOI":"10.7554\/eLife.68864","article-title":"Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity","volume":"10","author":"Myers","year":"2021","journal-title":"eLife"},{"key":"2026082409475336400_RSIF20251018C63","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3389\/fmicb.2018.01554","article-title":"Influenza virus infection model with density dependence supports biphasic viral decay","volume":"9","author":"Smith","year":"2018","journal-title":"Front. Microbiol."},{"key":"2026082409475336400_RSIF20251018C64","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jtbi.2014.01.008","article-title":"Modeling inoculum dose dependent patterns of acute virus infections","volume":"347","author":"Li","year":"2014","journal-title":"J. Theor. Biol."},{"key":"2026082409475336400_RSIF20251018C65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/jtbi.1997.0548","article-title":"Target cell limited and immune control models of HIV infection: a comparison","volume":"190","author":"De Boer","year":"1998","journal-title":"J. Theor. Biol."},{"key":"2026082409475336400_RSIF20251018C66","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jtbi.1995.0165","article-title":"Towards a general function describing T cell proliferation","volume":"175","author":"De Boer","year":"1995","journal-title":"J. Theor. Biol."},{"key":"2026082409475336400_RSIF20251018C67","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4269\/ajtmh.1989.40.418","article-title":"An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate","volume":"40","author":"Innis","year":"1989","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2026082409475336400_RSIF20251018C68","doi-asserted-by":"crossref","first-page":"e0187409","DOI":"10.1371\/journal.pone.0187409","article-title":"HCV kinetic and modeling analyses project shorter durations to cure under combined therapy with daclatasvir and asunaprevir in chronic HCV-infected patients","volume":"12","author":"Canini","year":"2017","journal-title":"PLoS One"},{"key":"2026082409475336400_RSIF20251018C69","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10928-014-9363-3","article-title":"Viral kinetic modeling: State of the art","volume":"41","author":"Canini","year":"2014","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"2026082409475336400_RSIF20251018C70","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/clpt.2010.35","article-title":"A comprehensive hepatitis c viral kinetic model explaining cure","volume":"87","author":"","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"2026082409475336400_RSIF20251018C71","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1399-3089.2009.00554.x","article-title":"Reference values of clinical chemistry and hematology parameters in rhesus monkeys (Macacamulatta)","volume":"16","author":"Chen","year":"2009","journal-title":"Xenotransplantation"},{"key":"2026082409475336400_RSIF20251018C72","doi-asserted-by":"crossref","first-page":"14823","DOI":"10.1038\/s41598-018-33167-7","article-title":"Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis","volume":"8","author":"Stahl","year":"2018","journal-title":"Sci. Rep."},{"key":"2026082409475336400_RSIF20251018C73","volume-title":"What is plasma","author":"NHS Blood Donation"},{"key":"2026082409475336400_RSIF20251018C74","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/biomet\/57.1.97","article-title":"Monte Carlo sampling methods using Markov chains and their applications","volume":"57","author":"Hastings","year":"1970","journal-title":"Biometrika"},{"key":"2026082409475336400_RSIF20251018C75","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41426-018-0168-0","article-title":"Dengue virus and the host innate immune response","volume":"7","author":"Uno","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"2026082409475336400_RSIF20251018C76","doi-asserted-by":"crossref","DOI":"10.1201\/9781351030144","author":"Albert","year":"2019","journal-title":"Probability and Bayesian modeling"},{"key":"2026082409475336400_RSIF20251018C77","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2025.1018","article-title":"Estimating the in vivo prophylactic effect of mosnodenvir, a novel dengue antiviral, on DENV-2 infection","author":"McCormack","year":"2026"}],"container-title":["Journal of the Royal Society Interface"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/rsif\/article-pdf\/doi\/10.1098\/rsif.2025.1018\/6155776\/rsif.2025.1018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rsif\/article-pdf\/doi\/10.1098\/rsif.2025.1018\/6155776\/rsif.2025.1018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:54:50Z","timestamp":1787579690000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rsif\/article\/23\/239\/20251018\/482037\/Estimating-the-in-vivo-prophylactic-effect-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":77,"journal-issue":{"issue":"239","published-print":{"date-parts":[[2026,6,10]]}},"URL":"https:\/\/doi.org\/10.1098\/rsif.2025.1018","relation":{},"ISSN":["1742-5662"],"issn-type":[{"value":"1742-5662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"article-number":"20251018"}}