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We have concluded that he suffered from Crohn's disease, located mainly in his upper small intestine. This explains his upper abdominal pain, his flatulence and vomiting, as well as his articular and neurological symptoms, his \u2018extreme fatigue\u2019, low fever and especially the chronic, relapsing course of his illness that evolved in bouts, did not affect his life expectancy and decreased with old age, and also the time of life at which it started. It apparently does not explain, however, many of his cutaneous symptoms. We do not support other diagnoses such as Chagas' disease, lactose intolerance or the many psychiatric conditions that have been postulated.<\/jats:p>","DOI":"10.1098\/rsnr.2006.0160","type":"journal-article","created":{"date-parts":[[2006,12,18]],"date-time":"2006-12-18T19:25:31Z","timestamp":1166469931000},"page":"23-29","source":"Crossref","is-referenced-by-count":35,"title":["Darwin's illness: a final diagnosis"],"prefix":"10.1098","volume":"61","author":[{"given":"Fernando","family":"Orrego","sequence":"first","affiliation":[{"name":"Santiago 6782468, Chile 1","department":["Origin of Living Beings, Faculty of Medicine, Universidad de los Andes"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Quintana","sequence":"additional","affiliation":[{"name":"Santiago 6782468, Chile 2","department":["Department of Internal Medicine, Faculty of Medicine, Universidad de los Andes,"]},{"name":"Santiago 6510260, Chile 3","department":["Department of Gastroenterology, School of Medicine, Catholic University of Chile,"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2006,12,18]]},"reference":[{"key":"2026010718572330100_bib1"},{"key":"2026010718572330100_bib2"},{"key":"2026010718572330100_bib3"},{"key":"2026010718572330100_bib4"},{"key":"2026010718572330100_bib5"},{"key":"2026010718572330100_bib6"},{"key":"2026010718572330100_bib7"},{"key":"2026010718572330100_bib8"},{"key":"2026010718572330100_bib9"},{"key":"2026010718572330100_bib10"},{"key":"2026010718572330100_bib11"},{"key":"2026010718572330100_bib12"},{"key":"2026010718572330100_bib13"},{"key":"2026010718572330100_bib14"},{"key":"2026010718572330100_bib15"},{"key":"2026010718572330100_bib16"},{"key":"2026010718572330100_bib17"},{"key":"2026010718572330100_bib18"},{"key":"2026010718572330100_bib19"},{"key":"2026010718572330100_bib20"},{"key":"2026010718572330100_bib21"},{"key":"2026010718572330100_bib22"},{"key":"2026010718572330100_bib23"},{"key":"2026010718572330100_bib24"},{"key":"2026010718572330100_bib25"},{"key":"2026010718572330100_bib26"},{"key":"2026010718572330100_bib27"},{"key":"2026010718572330100_bib28"},{"key":"2026010718572330100_bib29"},{"key":"2026010718572330100_bib30"},{"key":"2026010718572330100_bib31"},{"key":"2026010718572330100_bib32"},{"key":"2026010718572330100_bib33"},{"key":"2026010718572330100_bib34"},{"key":"2026010718572330100_bib35"},{"key":"2026010718572330100_bib36"},{"key":"2026010718572330100_bib37"},{"key":"2026010718572330100_bib38"},{"key":"2026010718572330100_bib39"},{"key":"2026010718572330100_bib40"},{"key":"2026010718572330100_bib41"},{"key":"2026010718572330100_bib42"},{"key":"2026010718572330100_bib43"},{"key":"2026010718572330100_bib44"},{"key":"2026010718572330100_bib45"},{"key":"2026010718572330100_bib46"},{"key":"2026010718572330100_bib47"},{"key":"2026010718572330100_bib48"},{"key":"2026010718572330100_bib49"}],"container-title":["Notes and Records of the Royal Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsnr.2006.0160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsnr.2006.0160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/rsnr\/article-pdf\/61\/1\/23\/429702\/rsnr.2006.0160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/royalsocietypublishing.org\/rsnr\/article-pdf\/61\/1\/23\/429702\/rsnr.2006.0160.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:57:27Z","timestamp":1767830247000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/rsnr\/article\/61\/1\/23\/61252\/Darwin-s-illness-a-final-diagnosis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,18]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,18]]},"published-print":{"date-parts":[[2007,1,22]]}},"URL":"https:\/\/doi.org\/10.1098\/rsnr.2006.0160","relation":{},"ISSN":["0035-9149","1743-0178"],"issn-type":[{"value":"0035-9149","type":"print"},{"value":"1743-0178","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,18]]}}}