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On review it is argued that his distrust and suspicions of others, and the fear that he might be harmed by criticism and his discoveries stolen, followed from his mother's separation from him in childhood and not, as has been claimed, from the developmental disorder of Asperger's syndrome. It is further firmly argued that his \u2018madness\u2019 of 1692 and 1693 was due to mercury poisoning from his alchemical experiments and not to clinical depression.<\/jats:p>","DOI":"10.1098\/rsnr.2007.0025","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T21:08:47Z","timestamp":1211404127000},"page":"289-300","update-policy":"https:\/\/doi.org\/10.1098\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Balancing Newton's mind: his singular behaviour and his madness of 1692\u201393"],"prefix":"10.1098","volume":"62","author":[{"given":"Milo","family":"Keynes","sequence":"first","affiliation":[{"name":"3 Brunswick WalkCambridge CB5 8DH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00102"},{"key":"e_1_3_2_43_2","unstructured":"Iliffe et al. Fitzwilliam notebook \u2018sins numbers 13 and 14\u2019. op. cit . (note 13) 1 7."},{"key":"e_1_3_2_44_2","first-page":"119","volume-title":"A secure base: clinical applications of attachment theory","author":"Bowlby J.","year":"1988"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6511.1779"},{"key":"e_1_3_2_46_2","unstructured":"Conduitt John Iliffe et al. \u2018Material I\u2014draft of memoir\u2019. op. cit . (note 13) 1 104."},{"key":"e_1_3_2_48_2","unstructured":"Conduitt J. Iliffe et al. \u2018Material III\u2014notes on Newton's character\u2019. op. cit . (note 13) 1 190."},{"key":"e_1_3_2_49_2","unstructured":"Storr op. cit . (note 44)."},{"key":"e_1_3_2_50_2","first-page":"362","volume-title":"Anecdotes, Observations, and Characters, of Books and Men, collected from the conversation of Mr Pope, and other eminent persons of his time","author":"Turnor","year":"1820"},{"key":"e_1_3_2_51_2","unstructured":"Newton \u2018Letter to Robert Hooke 5 February 1675\/6\u2019. op. cit . 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