{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:43:12Z","timestamp":1762641792163},"reference-count":21,"publisher":"The Royal Society","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"Medical Research Council","award":["MC_U122680443"],"award-info":[{"award-number":["MC_U122680443"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n            Indirect assays have claimed to quantify phytate (InsP\n            <jats:sub>6<\/jats:sub>\n            ) levels in human biofluids, but these have been based on the initial assumption that InsP\n            <jats:sub>6<\/jats:sub>\n            is there, an assumption that our more direct assays disprove. We have shown that InsP\n            <jats:sub>6<\/jats:sub>\n            does not and cannot (because of the presence of an active InsP\n            <jats:sub>6<\/jats:sub>\n            phosphatase in serum) exist in mammalian serum or urine. Therefore, any physiological effects of dietary InsP\n            <jats:sub>6<\/jats:sub>\n            can only be due either to its actions in the gut as a polyvalent cation chelator, or to inositol generated by its dephosphorylation by gut microflora.\n          <\/jats:p>","DOI":"10.1098\/rsob.150181","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T10:08:18Z","timestamp":1447841298000},"page":"150181","update-policy":"http:\/\/dx.doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["There is no \u2018Conundrum\u2019 of InsP\n            <sub>6<\/sub>"],"prefix":"10.1098","volume":"5","author":[{"given":"Robin F.","family":"Irvine","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J.","family":"Bulley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK"},{"name":"Department of Haematology, Cambridge University Hospitals NHS Trust, Hills Road, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Saiardi","sequence":"additional","affiliation":[{"name":"Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2015,11]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.150014"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081417"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520150105"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0345805"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.11.003"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2007.10.041"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/pca.1254"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(98)00164-0"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00155-4"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.03.023"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.12.016"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.12.015"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.02.015"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.4.713"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/AEM.43.4.753-756.1982","article-title":"Phytate hydrolysis by germfree and conventional rats","volume":"43","author":"Wise A","year":"1982","journal-title":"Appl. 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