{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:25:37Z","timestamp":1790807137558,"version":"4.1.0"},"reference-count":36,"publisher":"The Royal Society","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>During embryogenesis, the three SOXF transcription factors, SOX7, SOX17 and SOX18, regulate the specification of the cardiovascular system and are also involved in the development of haematopoiesis. The ectopic expression of SOX17 in both embryonic and adult blood cells enhances self-renewal. Likewise, the enforced expression of SOX7 during embryonic development promotes the proliferation of early blood progenitors and blocks lineage commitment. However, whether SOX7 expression can also affect the self-renewal of adult blood progenitors has never been explored. In this study, we demonstrate using an inducible transgenic mouse model that the enforced expression of<jats:italic>Sox7 ex vivo<\/jats:italic>in bone marrow\/stroma cell co-culture promotes the proliferation of blood progenitors which retain multi-lineage short-term engrafting capacity. Furthermore, SOX7 expression induces a profound block in the generation of B lymphocytes. Correspondingly, the ectopic expression of SOX7<jats:italic>in vivo<\/jats:italic>results in dramatic alterations of the haematopoietic system, inducing the proliferation of blood progenitors in the bone marrow while blocking B lymphopoiesis. In addition, SOX7 expression induces extra-medullary haematopoiesis in the spleen and liver. Together, these data demonstrate that the uncontrolled expression of the transcription factor SOX7 in adult haematopoietic cells has dramatic consequences on blood homeostasis.<\/jats:p>","DOI":"10.1098\/rsob.160070","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T09:14:40Z","timestamp":1468401280000},"page":"160070","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development"],"prefix":"10.1098","volume":"6","author":[{"given":"Sara","family":"Cuvertino","sequence":"first","affiliation":[{"name":"Stem Cell Hematopoiesis Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Lacaud","sequence":"additional","affiliation":[{"name":"Stem Cell Biology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Kouskoff","sequence":"additional","affiliation":[{"name":"Stem Cell Hematopoiesis Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2016,7]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00223-X"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091793"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.12.007"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00497-5"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.008"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.08.017"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.06.093"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.034827"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143650"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.01.012"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.011"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2724"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.071282"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-226290"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-247395"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07679"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01485-13"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2052911"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12147"},{"key":"e_1_3_7_21_2","article-title":"Hematoxylin and eosin staining of tissue and cell sections","volume":"2014","author":"Fisher A","year":"2008","journal-title":"CSH Protoc"},{"key":"e_1_3_7_22_2","first-page":"67","article-title":"Differentiation of B lymphocytes from hematopoietic stem cells","volume":"271","author":"Vieira P","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.5.1213"},{"key":"e_1_3_7_24_2","article-title":"Isolation of hematopoietic stem cells from human cord blood","author":"Jaatinen T","year":"2007","journal-title":"Curr. Protocols Stem Cell Biol"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1938"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1845"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1329"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07391"},{"key":"e_1_3_7_29_2","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1242\/dev.129.10.2367","article-title":"Depletion of definitive gut endoderm in Sox17-null mutant mice","volume":"129","author":"Kanai-Azuma M","year":"2002","journal-title":"Development"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3609"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403724200"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds241"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/375614"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-580993"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/356612a0"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80648-2"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.3777"}],"container-title":["Open Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.160070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsob.160070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.160070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:21:39Z","timestamp":1656811299000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsob.160070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1098\/rsob.160070"],"URL":"https:\/\/doi.org\/10.1098\/rsob.160070","relation":{},"ISSN":["2046-2441"],"issn-type":[{"value":"2046-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"2016-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}