{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:10:11Z","timestamp":1767859811058,"version":"3.49.0"},"reference-count":52,"publisher":"The Royal Society","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["MAMMIFERT"],"award-info":[{"award-number":["MAMMIFERT"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n            Recurrent spontaneous abortion (RSA) is a common cause of infertility, but previous attempts at identifying RSA causative genes have been relatively unsuccessful. Such failure to describe RSA aetiological genes might be explained by the fact that reproductive phenotypes should be considered as quantitative traits resulting from the intricate interaction of numerous genetic, epigenetic and environmental factors. Here, we studied an interspecific recombinant congenic strain (IRCS) of\n            <jats:italic>Mus musculus<\/jats:italic>\n            from the C57BL6\/J strain of mice harbouring an approximate 5 Mb DNA fragment from chromosome 13 from\n            <jats:italic>Mus spretus<\/jats:italic>\n            mice (66H-MMU13 strain), with a high rate of embryonic resorption (ER). Transcriptome analyses of endometrial and placental tissues from these mice showed a deregulation of many genes associated with the coagulation and inflammatory response pathways. Bioinformatics approaches led us to select\n            <jats:italic>Foxd1<\/jats:italic>\n            as a candidate gene potentially related to ER and RSA. Sequencing analysis of\n            <jats:italic>Foxd1<\/jats:italic>\n            in the 66H-MMU13 strain, and in 556 women affected by RSA and 271 controls revealed non-synonymous sequence variants.\n            <jats:italic>In vitro<\/jats:italic>\n            assays revealed that some led to perturbations in FOXD1 transactivation properties on promoters of genes having key roles during implantation\/placentation, suggesting a role of this gene in mammalian implantation processes.\n          <\/jats:p>","DOI":"10.1098\/rsob.160109","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T09:09:07Z","timestamp":1476868147000},"page":"160109","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of\n            <i>FOXD1<\/i>\n            variants with adverse pregnancy outcomes in mice and humans"],"prefix":"10.1098","volume":"6","author":[{"given":"Paul","family":"Laissue","sequence":"first","affiliation":[{"name":"Institut Cochin, Universit\u00e9 Paris Descartes, CNRS (UMR 8104), Paris, France"},{"name":"Inserm, U1016 Paris, France"},{"name":"Centro de Investigaci\u00f3n en Gen\u00e9tica y Gen\u00f3mica-CIGGUR, Grupo GENIUROS, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Besma","family":"Lakhal","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magalie","family":"Vatin","sequence":"additional","affiliation":[{"name":"Institut Cochin, Universit\u00e9 Paris Descartes, CNRS (UMR 8104), Paris, France"},{"name":"Inserm, U1016 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Albert Einstein College of Medicine, New York, NY 10461, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00ebtan","family":"Burgio","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de G\u00e9n\u00e9tique des Mammif\u00e8res, Paris, France"},{"name":"Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, the Australian National University, 131 Garran Road, Canberra 2601, Australian Capital Territory, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Mercier","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital, N\u00eemes. Faculty of Pharmacy and Research Team EA 2992, University of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther Dos","family":"Santos","sequence":"additional","affiliation":[{"name":"GIG-EA 7404, Universit\u00e9 de Versailles-Saint Quentin en Yvelines, Unit\u00e9 de Formation et de Recherche des Sciences de la Sant\u00e9 Simone Veil, 78180 Montigny-le-Bretonneux, France"},{"name":"Service de Biologie M\u00e9dicale, Centre Hospitalier de Poissy-Saint-Germain, 78300 Poissy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Buffat","sequence":"additional","affiliation":[{"name":"Centre National de la Recherche Scientifique UMR 7278, IRD198, INSERM U1095, Aix-Marseille Universit\u00e9, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Carolina","family":"Sierra-Diaz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Gen\u00e9tica y Gen\u00f3mica-CIGGUR, Grupo GENIUROS, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Renault","sequence":"additional","affiliation":[{"name":"Institut Cochin, Universit\u00e9 Paris Descartes, CNRS (UMR 8104), Paris, France"},{"name":"Inserm, U1016 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Montagutelli","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de G\u00e9n\u00e9tique des Mammif\u00e8res, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Monget","sequence":"additional","affiliation":[{"name":"INRA\u2013CNRS, Universit\u00e9 de Tours\u2014Haras Nationaux, IFR 135, 37380 Nouzilly, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiner A.","family":"Veitia","sequence":"additional","affiliation":[{"name":"Institut Cochin, Universit\u00e9 Paris Descartes, CNRS (UMR 8104), Paris, France"},{"name":"Inserm, U1016 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"M\u00e9hats","sequence":"additional","affiliation":[{"name":"Institut Cochin, Universit\u00e9 Paris Descartes, CNRS (UMR 8104), Paris, France"},{"name":"Inserm, U1016 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Fellous","sequence":"additional","affiliation":[{"name":"Institut Cochin, Universit\u00e9 Paris Descartes, CNRS (UMR 8104), Paris, France"},{"name":"Inserm, U1016 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Gris","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital, N\u00eemes. 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