{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:45:49Z","timestamp":1771469149019,"version":"3.50.1"},"reference-count":46,"publisher":"The Royal Society","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272747"],"award-info":[{"award-number":["81272747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572297"],"award-info":[{"award-number":["81572297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n            Long non-coding RNA LINC00152 had been reported as an oncogene in gastric and hepatocellular cancer. In this study, we show that LINC00152 is overexpressed in gallbladder cancer (GBC) tissue samples and cell lines. The high LINC00152 levels correlated negatively with the overall survival time in GBC patients. Functionally, LINC00152 dramatically promoted cell migration, invasion and epithelial\u2013mesenchymal transition (EMT) progression\n            <jats:italic>in vitro. In vivo<\/jats:italic>\n            , LINC00152 overexpression significantly promoted tumour peritoneal spreading and metastasis. Mechanistic analyses indicated that LINC00152 functions as a molecular sponge for miR-138, which directly suppresses the expression of hypoxia inducible factor-1\u03b1 (HIF-1\u03b1). We revealed that miR-138 is a suppressor of GBC cell metastasis and EMT progression, and a similar phenomenon was observed in HIF-1\u03b1 knockdown NOZ cells. Through binding to miR-138, LINC00152 has an oncogenic effect on GBC. Overall, our study suggested that the LINC00152\/miR-138\/HIF-1\u03b1 pathway potentiates the progression of GBC, and LINC00152 may be a novel therapeutic target.\n          <\/jats:p>","DOI":"10.1098\/rsob.160247","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T10:10:18Z","timestamp":1484129418000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":93,"title":["RETRACTED: Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial\u2013mesenchymal transition by regulating HIF-1\u03b1 via miR-138"],"prefix":"10.1098","volume":"7","author":[{"given":"Qiang","family":"Cai","sequence":"first","affiliation":[{"name":"Department of General Surgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200092, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200092, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhe","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200092, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200092, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200092, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0779-4096","authenticated-orcid":false,"given":"Zhiwei","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200092, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2017,1]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0302"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.052"},{"key":"e_1_3_7_4_2","first-page":"221","article-title":"Gallbladder cancer","volume":"3","author":"Rakic M","year":"2014","unstructured":"Rakic M, Patrlj L, Kopljar M, Klicek R, Kolovrat M, Loncar B, Busic Z. 2014 Gallbladder cancer. 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