{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:55:54Z","timestamp":1792079754941,"version":"4.4.0"},"reference-count":408,"publisher":"The Royal Society","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Normal brain development is highly dependent on the timely coordinated actions of genetic and environmental processes, and an aberration can lead to neurodevelopmental disorders (NDDs). Intellectual disability (ID) and autism spectrum disorders (ASDs) are a group of co-occurring NDDs that affect between 3% and 5% of the world population, thus presenting a great challenge to society. This problem calls for the need to understand the pathobiology of these disorders and to design new therapeutic strategies. One approach towards this has been the development of multiple analogous mouse models. This review discusses studies conducted in the mouse models of five major monogenic causes of ID and ASDs:<jats:italic>Fmr1, Syngap1, Mecp2, Shank2\/3<\/jats:italic>and<jats:italic>Neuroligins\/Neurnexins.<\/jats:italic>These studies reveal that, despite having a diverse molecular origin, the effects of these mutations converge onto similar or related aetiological pathways, consequently giving rise to the typical phenotype of cognitive, social and emotional deficits that are characteristic of ID and ASDs. This convergence, therefore, highlights common pathological nodes that can be targeted for therapy. Other than conventional therapeutic strategies such as non-pharmacological corrective methods and symptomatic alleviation, multiple studies in mouse models have successfully proved the possibility of pharmacological and genetic therapy enabling functional recovery.<\/jats:p>","DOI":"10.1098\/rsob.180265","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T07:52:46Z","timestamp":1560325966000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":66,"title":["Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour"],"prefix":"10.1098","volume":"9","author":[{"given":"Vijaya","family":"Verma","sequence":"first","affiliation":[{"name":"Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhik","family":"Paul","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Amrapali Vishwanath","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupesh","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7625-6430","authenticated-orcid":true,"given":"James P.","family":"Clement","sequence":"additional","affiliation":[{"name":"Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21974"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112014"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.5607\/en.2015.24.4.257"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033224"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/CHI.0b013e31818b1c63"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202556109"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2011.10.008"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5395"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81008-9"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.02.001"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20247"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2270"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.5042\/amhid.2011.0015"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40489-014-0028-3"},{"key":"e_1_3_5_17_2","first-page":"1","article-title":"How nutritional status, diet and dietary supplements can affect autism. A review","volume":"64","author":"Kawicka A","year":"2013","unstructured":"Kawicka A, Regulska-Ilow B. 2013 How nutritional status, diet and dietary supplements can affect autism. A review. Roczniki Pa\u0144stwowego Zak\u0142adu Higieny 64, 1-12.","journal-title":"Roczniki Pa\u0144stwowego Zak\u0142adu Higieny"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.09.010"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1087-15.2015"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.08.001"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3484"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1069-16.2016"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-5-11"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.13540.1"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2010.12.018"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2989"},{"key":"e_1_3_5_27_2","unstructured":"World Health Organization. Autism spectrum disorders. 2017 [cited 2018 8th December]. See https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/autism-spectrum-disorders"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009886"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30841"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042711-140053"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.02.015"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304063"},{"issue":"2","key":"e_1_3_5_34_2","first-page":"s132","article-title":"Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis","volume":"50","author":"Katz G","year":"2008","unstructured":"Katz G, Lazcano-Ponce E. 2008 Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis. Salud Publica Mex. 50(Suppl. 2), s132-s141.","journal-title":"Salud Publica Mex."},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508093112"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3999"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09146"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-010-9055-2"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/35088558"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/361031a0"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00400-1"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1963.26.6.1003"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-010-9148-4"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1787"},{"key":"e_1_3_5_45_2","first-page":"11","article-title":"Re-opening windows: manipulating critical periods for brain development","volume":"2012","author":"Hensch TK","year":"2012","unstructured":"Hensch TK, Bilimoria PM. 2012 Re-opening windows: manipulating critical periods for brain development. Cerebrum 2012, 11.","journal-title":"Cerebrum"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.125.3247.549"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008455"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009022"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1962.sp006837"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-10-03684.1997"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1844"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5495.1321"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90893.2008"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.009"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2012.08075.x"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/35009107"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050019"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00569.2005"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00215-4"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-23-08997.1997"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-07-02469.1997"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.5.2587"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1279803"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/375325a0"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00194-5"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.1.345"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.08.001"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/35004582"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0443-09.2009"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00297-5"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/286073"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4812-10.2010"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5393.1504"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-22-j0003.1999"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.05.016.2009"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183962"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.022"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81509-3"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201720170238"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-017-9186-9"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.6861"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.265066"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00032"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011001300007"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.07.029"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.223"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-04-01119.2003"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3213-04.2004"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.045"},{"key":"e_1_3_5_90_2","first-page":"23","article-title":"FMR1 knockout mice: a model to study fragile X mental retardation","volume":"55","author":"Oostra B","year":"1994","unstructured":"Oostra B, Bakker C, Reyniers E. 1994 FMR1 knockout mice: a model to study fragile X mental retardation. Am. J. Hum. Genet. 55, 23-33.","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00041"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.08.019"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1814"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5302-13.2014"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.07.005"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2336"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092169"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21380"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/85899"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506499112"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012104107"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.02.014"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.03.011"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912257106"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401626101"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.08.039"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr212"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-1-15"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09965"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146221"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111093108"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00085"},{"key":"e_1_3_5_113_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12077"},{"key":"e_1_3_5_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.036"},{"key":"e_1_3_5_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.045"},{"key":"e_1_3_5_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.182"},{"key":"e_1_3_5_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80471-7"},{"key":"e_1_3_5_118_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1900"},{"key":"e_1_3_5_119_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37189"},{"key":"e_1_3_5_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.05.015"},{"key":"e_1_3_5_121_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.026351.112"},{"key":"e_1_3_5_122_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07079.x"},{"key":"e_1_3_5_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2018.03.008"},{"key":"e_1_3_5_124_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805392"},{"key":"e_1_3_5_125_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103451"},{"key":"e_1_3_5_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13340"},{"key":"e_1_3_5_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0268-0"},{"key":"e_1_3_5_128_2","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12273"},{"key":"e_1_3_5_129_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22248"},{"key":"e_1_3_5_130_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35930"},{"key":"e_1_3_5_131_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1554098"},{"key":"e_1_3_5_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2013.04.013"},{"key":"e_1_3_5_133_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-017-0425-4"},{"key":"e_1_3_5_134_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12464"},{"key":"e_1_3_5_135_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03908.x"},{"key":"e_1_3_5_136_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4695-08.2008"},{"key":"e_1_3_5_137_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0765-13.2013"},{"key":"e_1_3_5_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00406-8"},{"key":"e_1_3_5_139_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-22-09721.2002"},{"key":"e_1_3_5_140_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-17-05382.1996"},{"key":"e_1_3_5_141_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314109200"},{"key":"e_1_3_5_142_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600084103"},{"key":"e_1_3_5_143_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01273"},{"key":"e_1_3_5_144_2","first-page":"1006","article-title":"Prevalence of carriers of premutation-size alleles of the FMRI gene\u2014and implications for the population genetics of the fragile X syndrome","volume":"57","author":"Rousseau F","year":"1995","unstructured":"Rousseau F, Rouillard P, Morel ML, Khandjian EW, Morgan K. 1995 Prevalence of carriers of premutation-size alleles of the FMRI gene\u2014and implications for the population genetics of the fragile X syndrome. Am. J. Hum. Genet. 57, 1006-1018.","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_5_145_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3500"},{"key":"e_1_3_5_146_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.6.3-4.154"},{"key":"e_1_3_5_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.11.028"},{"key":"e_1_3_5_148_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291644"},{"key":"e_1_3_5_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90397-H"},{"key":"e_1_3_5_150_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.6.397"},{"key":"e_1_3_5_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90283-5"},{"key":"e_1_3_5_152_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2828"},{"key":"e_1_3_5_153_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.24.18382"},{"key":"e_1_3_5_154_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.252.5009.1097"},{"key":"e_1_3_5_155_2","doi-asserted-by":"publisher","DOI":"10.1038\/8807"},{"key":"e_1_3_5_156_2","doi-asserted-by":"publisher","DOI":"10.1086\/342931"},{"key":"e_1_3_5_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90125-I"},{"key":"e_1_3_5_158_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.877551"},{"key":"e_1_3_5_159_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.11.794"},{"key":"e_1_3_5_160_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.4.460"},{"key":"e_1_3_5_161_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.012518"},{"key":"e_1_3_5_162_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011811-132457"},{"key":"e_1_3_5_163_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(200023)97:3<189::AID-AJMG1036>3.0.CO;2-J"},{"key":"e_1_3_5_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(02)00299-X"},{"key":"e_1_3_5_165_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0317"},{"key":"e_1_3_5_166_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320380223"},{"key":"e_1_3_5_167_2","first-page":"23","article-title":"Fmr1 knockout mice: a model to study fragile X mental retardation","volume":"78","author":"Bakker CE","year":"1994","unstructured":"Bakker CE et al. 1994 Fmr1 knockout mice: a model to study fragile X mental retardation. Cell 78, 23-33. (doi:10.1016\/0092-8674(94)90569-x)","journal-title":"Cell"},{"key":"e_1_3_5_168_2","first-page":"231","article-title":"A marker X chromosome","volume":"21","author":"Lubs HA","year":"1969","unstructured":"Lubs HA. 1969 A marker X chromosome. Am. J. Hum. Genet. 21, 231-244.","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_5_169_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320170108"},{"key":"e_1_3_5_170_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00447283"},{"key":"e_1_3_5_171_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295459"},{"key":"e_1_3_5_172_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072060-00015"},{"key":"e_1_3_5_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00285-7"},{"key":"e_1_3_5_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.05.046"},{"key":"e_1_3_5_175_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1520-05.2005"},{"key":"e_1_3_5_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00292-X"},{"key":"e_1_3_5_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00296-5"},{"key":"e_1_3_5_178_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960809)64:2<241::AID-AJMG1>3.0.CO;2-X"},{"key":"e_1_3_5_179_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200409000-00107"},{"key":"e_1_3_5_180_2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/gbb.12071","article-title":"Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome","volume":"12","author":"King MK","year":"2013","unstructured":"King MK, Jope RS. 2013 Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome. Genes Brain Behav. 12, 723-731. (doi:10.1111\/gbb.12071)","journal-title":"Genes Brain Behav."},{"key":"e_1_3_5_181_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2276-6"},{"key":"e_1_3_5_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.009"},{"key":"e_1_3_5_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.12.001"},{"key":"e_1_3_5_184_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.8.1145"},{"key":"e_1_3_5_185_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2005.00123.x"},{"key":"e_1_3_5_186_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10005"},{"key":"e_1_3_5_187_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.122.2.293"},{"key":"e_1_3_5_188_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.11.019"},{"key":"e_1_3_5_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.12.041"},{"key":"e_1_3_5_190_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044816"},{"key":"e_1_3_5_191_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320380276"},{"key":"e_1_3_5_192_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb01499.x"},{"key":"e_1_3_5_193_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0013047"},{"key":"e_1_3_5_194_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017073"},{"key":"e_1_3_5_195_2","doi-asserted-by":"publisher","DOI":"10.1002\/aur.168"},{"key":"e_1_3_5_196_2","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2014.01024"},{"key":"e_1_3_5_197_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.04.042"},{"key":"e_1_3_5_198_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094222"},{"key":"e_1_3_5_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.04.001"},{"key":"e_1_3_5_200_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08759"},{"key":"e_1_3_5_201_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687814"},{"key":"e_1_3_5_202_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B"},{"key":"e_1_3_5_203_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1790-06.2006"},{"key":"e_1_3_5_204_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.10.5401"},{"key":"e_1_3_5_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02363-1"},{"key":"e_1_3_5_206_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0577-10.2010"},{"key":"e_1_3_5_207_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012496107"},{"key":"e_1_3_5_208_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.02.001"},{"key":"e_1_3_5_209_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.4.556"},{"key":"e_1_3_5_210_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0054-07.2007"},{"key":"e_1_3_5_211_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.10.1045"},{"key":"e_1_3_5_212_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.160929"},{"key":"e_1_3_5_213_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5469.1254"},{"key":"e_1_3_5_214_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122205699"},{"key":"e_1_3_5_215_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.98905"},{"key":"e_1_3_5_216_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408368102"},{"key":"e_1_3_5_217_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06314.x"},{"key":"e_1_3_5_218_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1496-08.2008"},{"key":"e_1_3_5_219_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2624-07.2007"},{"key":"e_1_3_5_220_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3660-10.2010"},{"key":"e_1_3_5_221_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar4338"},{"key":"e_1_3_5_222_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.06.027"},{"key":"e_1_3_5_223_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8423420"},{"key":"e_1_3_5_224_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.09.008"},{"key":"e_1_3_5_225_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90752.2008"},{"key":"e_1_3_5_226_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn159"},{"key":"e_1_3_5_227_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247190"},{"key":"e_1_3_5_228_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.017"},{"key":"e_1_3_5_229_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.06.046"},{"key":"e_1_3_5_230_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3246-12.2013"},{"key":"e_1_3_5_231_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-335"},{"key":"e_1_3_5_232_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7692601"},{"key":"e_1_3_5_233_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90420-U"},{"key":"e_1_3_5_234_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-91"},{"key":"e_1_3_5_235_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00566-9"},{"key":"e_1_3_5_236_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1276805"},{"key":"e_1_3_5_237_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.17.4803"},{"key":"e_1_3_5_238_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.013"},{"key":"e_1_3_5_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.031"},{"key":"e_1_3_5_240_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1025202"},{"key":"e_1_3_5_241_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1022002"},{"key":"e_1_3_5_242_2","doi-asserted-by":"publisher","DOI":"10.1155\/JBB\/2006\/64347"},{"key":"e_1_3_5_243_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.035"},{"key":"e_1_3_5_244_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.8.1083"},{"key":"e_1_3_5_245_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2150"},{"key":"e_1_3_5_246_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(03)00004-5"},{"key":"e_1_3_5_247_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013559"},{"key":"e_1_3_5_248_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.004"},{"key":"e_1_3_5_249_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg350"},{"key":"e_1_3_5_250_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.05.006"},{"key":"e_1_3_5_251_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2969-07.2007"},{"key":"e_1_3_5_252_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.1500809"},{"key":"e_1_3_5_253_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707484104"},{"key":"e_1_3_5_254_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C800055200"},{"key":"e_1_3_5_255_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3696-09.2010"},{"key":"e_1_3_5_256_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.04.009"},{"key":"e_1_3_5_257_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.024"},{"key":"e_1_3_5_258_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-14-05139.2001"},{"key":"e_1_3_5_259_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30709"},{"key":"e_1_3_5_260_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.003"},{"key":"e_1_3_5_261_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1057320"},{"key":"e_1_3_5_262_2","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_3_5_263_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30016"},{"key":"e_1_3_5_264_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.07.001"},{"key":"e_1_3_5_265_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003350010035"},{"key":"e_1_3_5_266_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.7.1253"},{"key":"e_1_3_5_267_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140412"},{"key":"e_1_3_5_268_2","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2016.1170896"},{"key":"e_1_3_5_269_2","first-page":"6302","article-title":"The quality of life in girls with Rett syndrome","volume":"8","author":"Parisi L","year":"2016","unstructured":"Parisi L, Di Filippo T, Roccella M. 2016 The quality of life in girls with Rett syndrome. Ment Illn. 8, 6302. (doi:10.4081\/mi.2016.6302)","journal-title":"Ment Illn."},{"key":"e_1_3_5_270_2","doi-asserted-by":"publisher","DOI":"10.1038\/85906"},{"key":"e_1_3_5_271_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2623-05.2006"},{"key":"e_1_3_5_272_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.07.025"},{"key":"e_1_3_5_273_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00768-7"},{"key":"e_1_3_5_274_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10027"},{"key":"e_1_3_5_275_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.05.001"},{"key":"e_1_3_5_276_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.07.006"},{"key":"e_1_3_5_277_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.037"},{"key":"e_1_3_5_278_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.02.062"},{"key":"e_1_3_5_279_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.018"},{"key":"e_1_3_5_280_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.07.005"},{"key":"e_1_3_5_281_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh282"},{"key":"e_1_3_5_282_2","doi-asserted-by":"publisher","DOI":"10.1038\/30764"},{"key":"e_1_3_5_283_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210256200"},{"key":"e_1_3_5_284_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007224200"},{"key":"e_1_3_5_285_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086446"},{"key":"e_1_3_5_286_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090842"},{"key":"e_1_3_5_287_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1491"},{"key":"e_1_3_5_288_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-8-36"},{"key":"e_1_3_5_289_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1516"},{"key":"e_1_3_5_290_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608056104"},{"key":"e_1_3_5_291_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90610-O"},{"key":"e_1_3_5_292_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.1.414"},{"key":"e_1_3_5_293_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn591"},{"key":"e_1_3_5_294_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-092910-154121"},{"key":"e_1_3_5_295_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw038"},{"key":"e_1_3_5_296_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6036"},{"key":"e_1_3_5_297_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.183"},{"key":"e_1_3_5_298_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80809-0"},{"key":"e_1_3_5_299_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1933"},{"key":"e_1_3_5_300_2","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-18"},{"key":"e_1_3_5_301_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004580"},{"key":"e_1_3_5_302_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.09.026"},{"key":"e_1_3_5_303_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3032-07.2008"},{"key":"e_1_3_5_304_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11208"},{"key":"e_1_3_5_305_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11015"},{"key":"e_1_3_5_306_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6107-11.2012"},{"key":"e_1_3_5_307_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4354-04.2005"},{"key":"e_1_3_5_308_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.258384"},{"key":"e_1_3_5_309_2","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22089"},{"key":"e_1_3_5_310_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.11.1851"},{"key":"e_1_3_5_311_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005678"},{"key":"e_1_3_5_312_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.03.016"},{"key":"e_1_3_5_313_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-72843-6_15"},{"key":"e_1_3_5_314_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002166"},{"key":"e_1_3_5_315_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80810-7"},{"key":"e_1_3_5_316_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11459"},{"key":"e_1_3_5_317_2","doi-asserted-by":"crossref","unstructured":"Tatavarty V Torrado Pacheco A Lin H Miska NJ Hengen KB Wagner FF Turrigiano GG. 2018 Autism-associated Shank3 is essential for homeostatic plasticity and neuronal circuit stability. bioRxiv 365445. (doi:10.1101\/365445)","DOI":"10.1101\/365445"},{"key":"e_1_3_5_318_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16971"},{"key":"e_1_3_5_319_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90396-8"},{"key":"e_1_3_5_320_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.5.2676"},{"key":"e_1_3_5_321_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32671-6"},{"key":"e_1_3_5_322_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.14.6410"},{"key":"e_1_3_5_323_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1621094"},{"key":"e_1_3_5_324_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.1100"},{"key":"e_1_3_5_325_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0470-10.2010"},{"key":"e_1_3_5_326_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00049-4"},{"key":"e_1_3_5_327_2","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3560581"},{"key":"e_1_3_5_328_2","doi-asserted-by":"publisher","DOI":"10.1078\/0171-9335-00410"},{"key":"e_1_3_5_329_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006946108"},{"key":"e_1_3_5_330_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05842.x"},{"key":"e_1_3_5_331_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5331.1511"},{"key":"e_1_3_5_332_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.06.023"},{"key":"e_1_3_5_333_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214718110"},{"key":"e_1_3_5_334_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.023"},{"key":"e_1_3_5_335_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488143"},{"key":"e_1_3_5_336_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80877-6"},{"key":"e_1_3_5_337_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3165-04.2005"},{"key":"e_1_3_5_338_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00647.2003"},{"key":"e_1_3_5_339_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.003"},{"key":"e_1_3_5_340_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1107470"},{"key":"e_1_3_5_341_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405939101"},{"key":"e_1_3_5_342_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006940"},{"key":"e_1_3_5_343_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07953"},{"key":"e_1_3_5_344_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.09.004"},{"key":"e_1_3_5_345_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.69"},{"key":"e_1_3_5_346_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37977"},{"key":"e_1_3_5_347_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr208"},{"key":"e_1_3_5_348_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4517-09.2010"},{"key":"e_1_3_5_349_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20630"},{"key":"e_1_3_5_350_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.80"},{"key":"e_1_3_5_351_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0032-08.2008"},{"key":"e_1_3_5_352_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4443"},{"key":"e_1_3_5_353_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.315"},{"key":"e_1_3_5_354_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.31"},{"key":"e_1_3_5_355_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00703.2015"},{"key":"e_1_3_5_356_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711555105"},{"key":"e_1_3_5_357_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07456"},{"key":"e_1_3_5_358_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803448105"},{"key":"e_1_3_5_359_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224896"},{"key":"e_1_3_5_360_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-6-23"},{"key":"e_1_3_5_361_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.07.024"},{"key":"e_1_3_5_362_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114028108"},{"key":"e_1_3_5_363_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.062"},{"key":"e_1_3_5_364_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224159"},{"key":"e_1_3_5_365_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1248-09.2009"},{"key":"e_1_3_5_366_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1136"},{"key":"e_1_3_5_367_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-08-02488.1996"},{"key":"e_1_3_5_368_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000656200"},{"key":"e_1_3_5_369_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1074"},{"key":"e_1_3_5_370_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.3.669"},{"key":"e_1_3_5_371_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5050-07.2008"},{"key":"e_1_3_5_372_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5123-05.2006"},{"key":"e_1_3_5_373_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)80018-X"},{"key":"e_1_3_5_374_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2356"},{"key":"e_1_3_5_375_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5289-14.2015"},{"key":"e_1_3_5_376_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2869-13.2014"},{"key":"e_1_3_5_377_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0473"},{"key":"e_1_3_5_378_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0619-8"},{"key":"e_1_3_5_379_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013053"},{"key":"e_1_3_5_380_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2006.10.003"},{"key":"e_1_3_5_381_2","first-page":"181","article-title":"Astrocytes as neural stem cells in the adult brain","volume":"7","author":"Gonzalez-Perez O","year":"2012","unstructured":"Gonzalez-Perez O, Quinones-Hinojosa A. 2012 Astrocytes as neural stem cells in the adult brain. J. Stem. Cells. 7, 181-188. (jsc.2012.7.3.181).","journal-title":"J. Stem. Cells."},{"key":"e_1_3_5_382_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.3.C922"},{"key":"e_1_3_5_383_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02519"},{"key":"e_1_3_5_384_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.02.006"},{"key":"e_1_3_5_385_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80043-9"},{"key":"e_1_3_5_386_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198405000-00001"},{"key":"e_1_3_5_387_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"e_1_3_5_388_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2003.11.005"},{"key":"e_1_3_5_389_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20557"},{"key":"e_1_3_5_390_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80086-0"},{"key":"e_1_3_5_391_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.08.002"},{"key":"e_1_3_5_392_2","unstructured":"Peters A Palay SL Webster HdeF. 1991 The fine structure of the nervous system. Neurons and their supporting cells 3rd edn. New York NY: Oxford University Press."},{"key":"e_1_3_5_393_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.036"},{"key":"e_1_3_5_394_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1684"},{"key":"e_1_3_5_395_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07690.x"},{"key":"e_1_3_5_396_2","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199794591.003.0031"},{"key":"e_1_3_5_397_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh009"},{"key":"e_1_3_5_398_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.11.023"},{"key":"e_1_3_5_399_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5027-09.2010"},{"key":"e_1_3_5_400_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.03.011"},{"key":"e_1_3_5_401_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0324-09.2009"},{"key":"e_1_3_5_402_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00316"},{"key":"e_1_3_5_403_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24638"},{"key":"e_1_3_5_404_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194637"},{"key":"e_1_3_5_405_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X12000105"},{"key":"e_1_3_5_406_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1435-8"},{"key":"e_1_3_5_407_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3185-16.2017"},{"key":"e_1_3_5_408_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34829"},{"key":"e_1_3_5_409_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.189"}],"container-title":["Open Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.180265","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsob.180265","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.180265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T15:57:05Z","timestamp":1721404625000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsob.180265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":408,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1098\/rsob.180265"],"URL":"https:\/\/doi.org\/10.1098\/rsob.180265","relation":{},"ISSN":["2046-2441"],"issn-type":[{"value":"2046-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"2018-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"180265"}}