{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T08:01:16Z","timestamp":1774771276505,"version":"3.50.1"},"reference-count":34,"publisher":"The Royal Society","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>\n            Exosomes carrying microRNAs (miRNAs) have been demonstrated to play critical roles in the regulation of development, growth and metastasis of cancer. Bioinformatic predictions identified differentially expressed SRY-box 9 (SOX9) in OC, and the regulatory miRNA miR-139-5p. Here, we aim to evaluate the function of exosomal miR-139-5p in the sensitivity of ovarian cancer (OC) cells to cis-diamminedichloroplatinum(II) (DDP). Expression pattern of miR-139-5p and SOX9 in ovarian cancer cells (SKOV3) and DDP-resistant cells (SKOV3\/DDP) was identified using reverse transcription quantitative polymerase chain reaction and western blot analysis. The relationship between miR-139-5p and SOX9 was validated using a dual-luciferase reporter assay. SKOV3\/DDP cell line was developed and introduced with miR-30a-5p mimic to analyse the effects of miR-30a-5p on resistance to DDP. The\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            effects of exosomal miR-30a-5p on resistance of SKOV3 cells to DDP were assessed in a co-culture system of exosomes and OC cells as well as in tumour-bearing nude mice. High expression of SOX9 and low expression of miR-30-5p were witnessed in OC. Furthermore, miR-30-5p, a downregulated miRNA in SKOV3\/DDP cells, increased the rate of cell apoptosis and enhanced the sensitivity of SKOV3\/DDP cells to DDP by targeting SOX9. Moreover, exosomes carrying miR-30a-5p were identified to sensitize SKOV3\/DDP cells to DDP both\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            . These data together supported an important conclusion that DDP-resistant OC cell-derived exosomal miR-30a-5p enhanced cellular sensitivity to DDP, highlighting a potential strategy to overcome drug resistance.\n          <\/jats:p>","DOI":"10.1098\/rsob.190173","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T23:05:13Z","timestamp":1588115113000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["RETRACTED: DDP-resistant ovarian cancer cells-derived exosomal microRNA-30a-5p reduces the resistance of ovarian cancer cells to DDP"],"prefix":"10.1098","volume":"10","author":[{"given":"Ronghua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Linyi People's Hospital, Linyi 276000, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, People's Hospital of Luozhuang District, Linyi 276000, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Linyi People's Hospital, Linyi 276000, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-0422","authenticated-orcid":true,"given":"Changxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Linyi People's Hospital, Linyi 276000, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.08.006"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.61"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3599"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw088"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.558288"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.12.061"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104715"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.246"},{"key":"e_1_3_7_10_2","first-page":"5601","article-title":"MicroRNA profiling of plasma exosomes from patients with ovarian cancer using high-throughput sequencing","volume":"17","author":"Zhang H","year":"2019","unstructured":"Zhang H, Xu S, Liu X. 2019 MicroRNA profiling of plasma exosomes from patients with ovarian cancer using high-throughput sequencing. Oncol. Lett. 17, 5601-5607. (doi:10.3892\/ol.2019.10220)","journal-title":"Oncol. Lett."},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.2016.1121107"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000460618"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2016.07.006"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81135"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0975-5"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.03.099"},{"key":"e_1_3_7_17_2","first-page":"43","article-title":"New strategy for overcoming resistance to chemotherapy of ovarian cancer","volume":"56","author":"Kigawa J","year":"2013","unstructured":"Kigawa J. 2013 New strategy for overcoming resistance to chemotherapy of ovarian cancer. 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