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This dynamically reversible modification is installed, removed and recognized by methyltransferases, demethylases and readers, respectively. This modification has been found in most eukaryotic mRNA, tRNA, rRNA and other non-coding RNA. Recent studies have revealed important regulatory functions of the m\n                    <jats:sup>6<\/jats:sup>\n                    A including effects on gene expression regulation, organism development and cancer development. In this review, we summarize the discovery and features of m\n                    <jats:sup>6<\/jats:sup>\n                    A, and briefly introduce the mammalian m\n                    <jats:sup>6<\/jats:sup>\n                    A writers, erasers and readers. Finally, we discuss progress in identifying additional functions of m\n                    <jats:sup>6<\/jats:sup>\n                    A and the outstanding questions about the regulatory effect of this widespread modification.\n                  <\/jats:p>","DOI":"10.1098\/rsob.200091","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T19:05:18Z","timestamp":1599591918000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Insight into m\n                    <sup>6<\/sup>\n                    A methylation from occurrence to functions"],"prefix":"10.1098","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-5989","authenticated-orcid":true,"given":"Wenxiu","family":"Ru","sequence":"first","affiliation":[{"name":"Key laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&amp;F University, 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