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Pathogenic outcomes are more common in women and generally include mild vaginitis or cervicitis. However, more serious effects associated with trichomoniasis include adverse reproductive outcomes. Like other infectious agents, pathogenesis from\n                    <jats:italic>Tv<\/jats:italic>\n                    infection is predicted to be the result of both parasite and host factors. At the site of infection, neutrophils are the most abundant immune cells present and probably play key roles in both parasite clearance and inflammatory pathology. Here, we discuss the evidence that neutrophils home to the site of\n                    <jats:italic>Tv<\/jats:italic>\n                    infection, kill the parasite, and that in some circumstances, parasites possibly evade neutrophil-directed killing.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , the parasite is killed by neutrophils using a novel antimicrobial mechanism called trogocytosis, which probably involves both innate and adaptive immunity. While mechanisms of evasion are mostly conjecture at present, the persistence of\n                    <jats:italic>Tv<\/jats:italic>\n                    infections in patients argues strongly for their existence. Additionally, many strains of\n                    <jats:italic>Tv<\/jats:italic>\n                    harbour microbial symbionts\n                    <jats:italic>Mycoplasma hominis<\/jats:italic>\n                    or\n                    <jats:italic>Trichomonasvirus<\/jats:italic>\n                    , which are both predicted to impact neutrophil responses against the parasite. Novel research tools, especially animal models, will help to reveal the true outcomes of many factors involved in neutrophil-\n                    <jats:italic>Tv<\/jats:italic>\n                    interactions during trichomoniasis.\n                  <\/jats:p>","DOI":"10.1098\/rsob.200192","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T03:05:23Z","timestamp":1599015923000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Neutrophil interactions with the sexually transmitted parasite\n                    <i>Trichomonas vaginalis:<\/i>\n                    implications for immunity and pathogenesis"],"prefix":"10.1098","volume":"10","author":[{"given":"Suhani B.","family":"Bhakta","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7324-0270","authenticated-orcid":true,"given":"Frances","family":"Mercer","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7594.1"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000128"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0723"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009991041"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01244-12"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.05.006"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01121.x"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.794-803.2004"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.08.007"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.19972.1"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2019-054079"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-015-0860-0"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1545-6"},{"key":"e_1_3_6_16_2","unstructured":"Prevention CfDCa. 2020 STD facts. 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