{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:29:18Z","timestamp":1791512958071,"version":"4.3.4"},"reference-count":90,"publisher":"The Royal Society","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["CIHR - FDN-143205"],"award-info":[{"award-number":["CIHR - FDN-143205"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Digit tip regeneration is one of the few examples of true multi-tissue regeneration in an adult mammal. The key step in this process is the formation of the blastema, a transient proliferating cell mass that generates the different cell types of the digit to replicate the original structure. Failure to form the blastema results in a lack of regeneration and has been postulated to be the reason why mammalian limbs cannot regrow following amputation. Understanding how the blastema forms and functions will help us to determine what is required for mammalian regeneration to occur and will provide insights into potential therapies for mammalian tissue regeneration and repair. This review summarizes the cellular and molecular mechanisms that influence murine blastema formation and govern digit tip regeneration.<\/jats:p>","DOI":"10.1098\/rsob.200194","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T03:12:36Z","timestamp":1601435556000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Cellular and molecular mechanisms that regulate mammalian digit tip regeneration"],"prefix":"10.1098","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0242-1418","authenticated-orcid":true,"given":"Mekayla A.","family":"Storer","sequence":"first","affiliation":[{"name":"Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Canada M5G 1L7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freda D.","family":"Miller","sequence":"additional","affiliation":[{"name":"Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Canada M5G 1L7"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Canada M5G 1A8"},{"name":"Department of Physiology, University of Toronto, Toronto, Canada M5G 1A8"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, Canada M5G 1A8"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140002"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800180-6.00004-9"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10248"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201300144"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077857"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm881"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08152"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147710"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900260203"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90038-3"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13998"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11499"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/208599a0"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402120211"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00298-2"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11164"},{"key":"e_1_3_6_18_2","first-page":"342","article-title":"Experimental investigations of morphogenesis in the growing antler","volume":"9","author":"Goss RJ","year":"1961","unstructured":"Goss RJ. 1961 Experimental investigations of morphogenesis in the growing antler. J. Embryol. Exp. Morphol. 9, 342-354.","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.07.007"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1686-y"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7100922"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.12.025"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-505-7_24"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00325287"},{"key":"e_1_3_6_25_2","first-page":"86","article-title":"Conservative management of guillotine amputation of the finger in children","volume":"8","author":"Douglas BS","year":"1972","unstructured":"Douglas BS. 1972 Conservative management of guillotine amputation of the finger in children. Aust. Paediatr. J. 8, 86-89. (doi:10.1111\/j.1440-1754.1972.tb01793.x)","journal-title":"Aust. Paediatr. J."},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80220-4"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1995.30410.x"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.11.035"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.34"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.002"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12214"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.150086"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140156"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12666"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(61)90009-4"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118017108"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10346"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.10.024"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.01.026"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.12.004"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.10.013"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090840408"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.02.031"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.04.013"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.03.006"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.81"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(77)90157-9"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(86)90062-X"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054764"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.11.007"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200509011"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.010"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01155"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2007.09.012"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0312"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2006.00296.x"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08899"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08804"},{"key":"e_1_3_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.04.014"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.064717"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90281-4"},{"key":"e_1_3_6_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050620204"},{"key":"e_1_3_6_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077804"},{"key":"e_1_3_6_64_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaq0681"},{"key":"e_1_3_6_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20268"},{"key":"e_1_3_6_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.51"},{"key":"e_1_3_6_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1518874112"},{"key":"e_1_3_6_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900722"},{"key":"e_1_3_6_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10049"},{"key":"e_1_3_6_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1085>3.0.CO;2-8"},{"key":"e_1_3_6_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401950111"},{"key":"e_1_3_6_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401340209"},{"key":"e_1_3_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.07.020"},{"key":"e_1_3_6_74_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.4.1065"},{"key":"e_1_3_6_75_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00710"},{"key":"e_1_3_6_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12044"},{"key":"e_1_3_6_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00139.x"},{"key":"e_1_3_6_78_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.042424"},{"key":"e_1_3_6_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.09.021"},{"key":"e_1_3_6_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08278-4"},{"key":"e_1_3_6_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2261"},{"key":"e_1_3_6_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/reg2.24"},{"key":"e_1_3_6_83_2","first-page":"84","article-title":"On the process of reproduction of the members of the aquatic salamander","volume":"16","author":"Todd TJ","year":"1823","unstructured":"Todd TJ. 1823 On the process of reproduction of the members of the aquatic salamander. Q. J. Sci. Lit. Arts 16, 84-96.","journal-title":"Q. J. Sci. Lit. Arts"},{"key":"e_1_3_6_84_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07827.x"},{"key":"e_1_3_6_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.08.003"},{"key":"e_1_3_6_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.04.017"},{"key":"e_1_3_6_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22529"},{"key":"e_1_3_6_88_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.133363"},{"key":"e_1_3_6_89_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2000.00277.x"},{"key":"e_1_3_6_90_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410097111"},{"key":"e_1_3_6_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.021"}],"container-title":["Open Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.200194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsob.200194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.200194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T05:20:40Z","timestamp":1669267240000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsob.200194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":90,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1098\/rsob.200194"],"URL":"https:\/\/doi.org\/10.1098\/rsob.200194","relation":{"has-review":[{"id-type":"doi","id":"10.1098\/RSOB.200194\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.200194\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.200194\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.200194\/v2\/response1","asserted-by":"object"}]},"ISSN":["2046-2441"],"issn-type":[{"value":"2046-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"2020-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"200194"}}