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The best characterized cardiovascular role is that of ADAMTS-13 in blood. Moderately low ADAMTS-13 levels increase the risk of ischeamic stroke and very low levels (less than 10%) can cause thrombotic thrombocytopenic purpura (TTP). Recombinant ADAMTS-13 is currently in clinical trials for treatment of TTP. Recently, new cardiovascular roles for ADAMTS proteases have been discovered. Several ADAMTS family members are important in the development of blood vessels and the heart, especially the valves. A number of studies have also investigated the potential role of ADAMTS-1, -4 and -5 in cardiovascular disease. They cleave proteoglycans such as versican, which represent major structural components of the arteries. ADAMTS-7 and -8 are attracting considerable interest owing to their implication in atherosclerosis and pulmonary arterial hypertension, respectively. Mutations in the\n                    <jats:italic>ADAMTS19<\/jats:italic>\n                    gene cause progressive heart valve disease and missense variants in\n                    <jats:italic>ADAMTS6<\/jats:italic>\n                    are associated with cardiac conduction. In this review, we discuss in detail the evidence for these and other cardiovascular roles of ADAMTS family members, their proteolytic substrates and the potential molecular mechanisms involved.\n                  <\/jats:p>","DOI":"10.1098\/rsob.200333","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T19:05:51Z","timestamp":1608663951000},"page":"200333","update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":99,"title":["ADAMTS proteases in cardiovascular physiology and disease"],"prefix":"10.1098","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-7776","authenticated-orcid":true,"given":"Salvatore","family":"Santamaria","sequence":"first","affiliation":[{"name":"Centre for Haematology, Imperial College London, Du Cane Road, London W12 0NN, 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