{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:55:56Z","timestamp":1790693756891,"version":"4.1.0"},"reference-count":242,"publisher":"The Royal Society","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"crossref","award":["Senior Postdoctoral Fellowship"],"award-info":[{"award-number":["Senior Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["DE190100174"],"award-info":[{"award-number":["DE190100174"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011718","name":"The Macular Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011718","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000377","name":"The Dunhill Medical Trust","doi-asserted-by":"crossref","award":["grant# RPGF1906\\173"],"award-info":[{"award-number":["grant# RPGF1906\\173"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["GNT1161439"],"award-info":[{"award-number":["GNT1161439"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary history. Genetic models in both vertebrates and invertebrates have shown that syndecans link to the actin cytoskeleton and can fine-tune cell adhesion, migration, junction formation, polarity and differentiation. Although often associated as co-receptors with other classes of receptors (e.g. integrins, growth factor and morphogen receptors), syndecans can nonetheless signal to the cytoplasm in discrete ways. Syndecan expression levels are upregulated in development, tissue repair and an array of human diseases, which has led to the increased appreciation that they may be important in pathogenesis not only as diagnostic or prognostic agents, but also as potential targets. Here, their functions in development and inflammatory diseases are summarized, including their potential roles as conduits for viral pathogen entry into cells.<\/jats:p>","DOI":"10.1098\/rsob.200377","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T19:12:20Z","timestamp":1612897940000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":65,"title":["Syndecan receptors: pericellular regulators in development and inflammatory disease"],"prefix":"10.1098","volume":"11","author":[{"given":"Sandeep","family":"Gopal","sequence":"first","affiliation":[{"name":"Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Arokiasamy","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csilla","family":"Pataki","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Biocentre 1.3.16, Ole Maal\u00f8es Vej 5, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Whiteford","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3409-7093","authenticated-orcid":true,"given":"John R.","family":"Couchman","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Centre, University of Copenhagen, Biocentre 1.3.16, Ole Maal\u00f8es Vej 5, 2200 Copenhagen N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160747"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.09.004"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100109-104126"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.116.198739"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.02.026"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2086"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-815"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2774-3"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20631"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011286"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0232"},{"key":"e_1_3_6_13_2","first-page":"276","article-title":"Insights into the key roles of proteoglycans in breast cancer biology and translational medicine","volume":"1855","author":"Theocharis AD","year":"2015","unstructured":"Theocharis AD et al. 2015 Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim. Biophys. Acta 1855, 276-300. (doi:10.1016\/j.bbcan.2015.03.00)","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.12.019"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02042"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21686"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.04.006"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010055"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.02.005"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.026"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018497"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201500092"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200602043"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03031"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-019-00617-0"},{"key":"e_1_3_6_26_2","first-page":"3236","article-title":"Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice","volume":"119","author":"Stanford KI","year":"2009","unstructured":"Stanford KI, Bishop JR, Foley EM, Gonzales JC, Niesman IR, Witztum JL, Esko JD. 2009 Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J. Clin. Invest. 119, 3236-3245. (doi:10.1172\/JCI38251)","journal-title":"J. Clin. Invest."},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00128"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.6.5.559"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.01.027"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.08.007"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12112"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvt024"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.21.14786"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.06.006"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.34.24113"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.06.019"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201501060"},{"key":"e_1_3_6_38_2","doi-asserted-by":"crossref","first-page":"e0174343","DOI":"10.1371\/journal.pone.0174343","article-title":"Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma","volume":"12","author":"Binder GA","year":"2017","unstructured":"Binder GA, Nussbaum G, Hermano E, Weizman B, Meirovitz A, Vlodavsky I, G\u00f6tte M, Elkin M. 2017 Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma. PLoS ONE 12, e0174343. (doi:10.1371\/journal.pone.0174343)","journal-title":"PLoS ONE"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/35075100"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.08.002"},{"key":"e_1_3_6_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09605-z"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4610"},{"key":"e_1_3_6_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy248"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10559"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1998"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2017.03.008"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20204989"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106268200"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-83"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.11805"},{"key":"e_1_3_6_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.444737"},{"key":"e_1_3_6_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00082"},{"key":"e_1_3_6_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.09.011"},{"key":"e_1_3_6_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1062-1"},{"key":"e_1_3_6_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-014-0279-8"},{"key":"e_1_3_6_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2502"},{"key":"e_1_3_6_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713433114"},{"key":"e_1_3_6_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15205-z"},{"key":"e_1_3_6_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14828"},{"key":"e_1_3_6_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13022"},{"key":"e_1_3_6_61_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.098129"},{"key":"e_1_3_6_62_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200711129"},{"key":"e_1_3_6_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.07.011"},{"key":"e_1_3_6_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2019.107087"},{"key":"e_1_3_6_65_2","first-page":"207","volume-title":"Essentials of glycobiology","author":"Lindahl U","year":"2017","unstructured":"Lindahl U, Couchman J, Kimata K, Esko JD. 2017 Proteoglycans and sulfated glycosaminoglycans. In Essentials of glycobiology (eds A Varki et al.), pp. 207-222. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press."},{"key":"e_1_3_6_66_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060713-035314"},{"key":"e_1_3_6_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0189-6"},{"key":"e_1_3_6_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-016-9749-0"},{"key":"e_1_3_6_69_2","first-page":"493","volume-title":"Essentials of glycology","author":"Esko JD","year":"2017","unstructured":"Esko JD, Prestegard JH, Linhardt RJ. 2017 Proteins that bind sulfated glycosaminoglycans. In Essentials of glycology (eds A Varki et al.), pp. 493-500. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press."},{"key":"e_1_3_6_70_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502065200"},{"key":"e_1_3_6_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-020-09925-z"},{"key":"e_1_3_6_72_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20170395"},{"key":"e_1_3_6_73_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005831"},{"key":"e_1_3_6_74_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.232645"},{"key":"e_1_3_6_75_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.679084"},{"key":"e_1_3_6_76_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0545"},{"key":"e_1_3_6_77_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.118.3.631"},{"key":"e_1_3_6_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2016.02.008"},{"key":"e_1_3_6_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.12.003"},{"key":"e_1_3_6_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12135"},{"key":"e_1_3_6_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.41"},{"key":"e_1_3_6_82_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1711308"},{"key":"e_1_3_6_83_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401028101"},{"key":"e_1_3_6_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.06.027"},{"key":"e_1_3_6_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.019"},{"key":"e_1_3_6_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2014.01.031"},{"key":"e_1_3_6_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.01.016"},{"key":"e_1_3_6_88_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi1005199"},{"key":"e_1_3_6_89_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-34521-1_1"},{"key":"e_1_3_6_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2016.10.001"},{"key":"e_1_3_6_91_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-34521-1_4"},{"key":"e_1_3_6_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2017.10.007"},{"key":"e_1_3_6_93_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00570"},{"key":"e_1_3_6_94_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170216114248"},{"key":"e_1_3_6_95_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415586961"},{"key":"e_1_3_6_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/77108"},{"key":"e_1_3_6_97_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.16.3055"},{"key":"e_1_3_6_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.01.006"},{"key":"e_1_3_6_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1399"},{"key":"e_1_3_6_100_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.45.27127"},{"key":"e_1_3_6_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.09.015"},{"key":"e_1_3_6_102_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.293.5535.1663"},{"key":"e_1_3_6_103_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200212083"},{"key":"e_1_3_6_104_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.140871"},{"key":"e_1_3_6_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30646"},{"key":"e_1_3_6_106_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-797050"},{"key":"e_1_3_6_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2013.167"},{"key":"e_1_3_6_108_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54469"},{"key":"e_1_3_6_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00180-6"},{"key":"e_1_3_6_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14259"},{"key":"e_1_3_6_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.11.002"},{"key":"e_1_3_6_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2498-z"},{"key":"e_1_3_6_113_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030758"},{"key":"e_1_3_6_114_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0660"},{"key":"e_1_3_6_115_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.285361"},{"key":"e_1_3_6_116_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201008087"},{"key":"e_1_3_6_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00019-2"},{"key":"e_1_3_6_118_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300726200"},{"key":"e_1_3_6_119_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403031200"},{"key":"e_1_3_6_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90512-W"},{"key":"e_1_3_6_121_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901148106"},{"key":"e_1_3_6_122_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155412460242"},{"key":"e_1_3_6_123_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00227"},{"key":"e_1_3_6_124_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14397"},{"key":"e_1_3_6_125_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155420937087"},{"key":"e_1_3_6_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.5"},{"key":"e_1_3_6_127_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1104"},{"key":"e_1_3_6_128_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12160"},{"key":"e_1_3_6_129_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308424200"},{"key":"e_1_3_6_130_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.793752"},{"key":"e_1_3_6_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.043"},{"key":"e_1_3_6_132_2","first-page":"205","article-title":"Developmental expression of the syndecans: possible function and regulation","volume":"1993","author":"Bernfield M","year":"1993","unstructured":"Bernfield M, Hinkes MT, Gallo RL. 1993 Developmental expression of the syndecans: possible function and regulation. Dev. Suppl. 1993, 205-212.","journal-title":"Dev. Suppl"},{"key":"e_1_3_6_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.153"},{"key":"e_1_3_6_134_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-009-0829-3"},{"key":"e_1_3_6_135_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155412464638"},{"key":"e_1_3_6_136_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01394"},{"key":"e_1_3_6_137_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.18.10914"},{"key":"e_1_3_6_138_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002183"},{"key":"e_1_3_6_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.04.004"},{"key":"e_1_3_6_140_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-12-research0088"},{"key":"e_1_3_6_141_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.55"},{"key":"e_1_3_6_142_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200603003"},{"key":"e_1_3_6_143_2","doi-asserted-by":"publisher","DOI":"10.1534\/g3.114.012591"},{"key":"e_1_3_6_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.02.036"},{"key":"e_1_3_6_145_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1986.0056"},{"key":"e_1_3_6_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80021-5"},{"key":"e_1_3_6_147_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102919"},{"key":"e_1_3_6_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.01.006"},{"key":"e_1_3_6_149_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609384200"},{"key":"e_1_3_6_150_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13064-016-0066-x"},{"key":"e_1_3_6_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.06.015"},{"key":"e_1_3_6_152_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.017350"},{"key":"e_1_3_6_153_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep25300"},{"key":"e_1_3_6_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.07.020"},{"key":"e_1_3_6_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90284-0"},{"key":"e_1_3_6_156_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201003081"},{"key":"e_1_3_6_157_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042883"},{"key":"e_1_3_6_158_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155411405057"},{"key":"e_1_3_6_159_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13940"},{"key":"e_1_3_6_160_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12280"},{"key":"e_1_3_6_161_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3270473"},{"key":"e_1_3_6_162_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2011"},{"key":"e_1_3_6_163_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0416"},{"key":"e_1_3_6_164_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00828"},{"key":"e_1_3_6_165_2","first-page":"1","article-title":"Syndecans in skeletal muscle development, regeneration and homeostasis","volume":"2","author":"Pisconti A","year":"2012","unstructured":"Pisconti A, Bernet JD, Olwin BB. 2012 Syndecans in skeletal muscle development, regeneration and homeostasis. Muscles Ligaments Tendons J. 2, 1-9.","journal-title":"Muscles Ligaments Tendons J."},{"key":"e_1_3_6_166_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-016-0104-8"},{"key":"e_1_3_6_167_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02856-6"},{"key":"e_1_3_6_168_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001274"},{"key":"e_1_3_6_169_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0338OC"},{"key":"e_1_3_6_170_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-34521-1_16"},{"key":"e_1_3_6_171_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt076"},{"key":"e_1_3_6_172_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-265447"},{"key":"e_1_3_6_173_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119377"},{"key":"e_1_3_6_174_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.9.060906.151959"},{"key":"e_1_3_6_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2013.02.001"},{"key":"e_1_3_6_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.08.019"},{"key":"e_1_3_6_177_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12934"},{"key":"e_1_3_6_178_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-11-0763"},{"key":"e_1_3_6_179_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304720"},{"key":"e_1_3_6_180_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800450-JLR200"},{"key":"e_1_3_6_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2003.09.006"},{"key":"e_1_3_6_182_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03059.x"},{"key":"e_1_3_6_183_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13374"},{"key":"e_1_3_6_184_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703747104"},{"key":"e_1_3_6_185_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230835"},{"key":"e_1_3_6_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2016.04.004"},{"key":"e_1_3_6_187_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545532"},{"key":"e_1_3_6_188_2","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v9.i12.220"},{"key":"e_1_3_6_189_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-01-761643"},{"key":"e_1_3_6_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.08.132"},{"key":"e_1_3_6_191_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2010.10.007"},{"key":"e_1_3_6_192_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.1853.x"},{"key":"e_1_3_6_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.008"},{"key":"e_1_3_6_194_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0294OC"},{"key":"e_1_3_6_195_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081278"},{"key":"e_1_3_6_196_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.067645"},{"key":"e_1_3_6_197_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1783"},{"key":"e_1_3_6_198_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140232"},{"key":"e_1_3_6_199_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117404"},{"key":"e_1_3_6_200_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155415568995"},{"key":"e_1_3_6_201_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-270.v1"},{"key":"e_1_3_6_202_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214737"},{"key":"e_1_3_6_203_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.235762"},{"key":"e_1_3_6_204_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308504"},{"key":"e_1_3_6_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.08.008"},{"key":"e_1_3_6_206_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500993"},{"key":"e_1_3_6_207_2","first-page":"ra36","article-title":"Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis","volume":"8","author":"Elfenbein A","year":"2012","unstructured":"Elfenbein A, Lanahan A, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M. 2012 Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis. Sci. Signal 8, ra36. (doi:10.1126\/scisignal.2002495)","journal-title":"Sci. Signal"},{"key":"e_1_3_6_208_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35298"},{"key":"e_1_3_6_209_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.063875"},{"key":"e_1_3_6_210_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37817"},{"key":"e_1_3_6_211_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29093"},{"key":"e_1_3_6_212_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa4616"},{"key":"e_1_3_6_213_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39193"},{"key":"e_1_3_6_214_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1939-2"},{"key":"e_1_3_6_215_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21222"},{"key":"e_1_3_6_216_2","doi-asserted-by":"publisher","DOI":"10.1369\/0022155419851103"},{"key":"e_1_3_6_217_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2407-9"},{"key":"e_1_3_6_218_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.12.016"},{"key":"e_1_3_6_219_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300430200"},{"key":"e_1_3_6_220_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043049"},{"key":"e_1_3_6_221_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0088OC"},{"key":"e_1_3_6_222_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-02-0099"},{"key":"e_1_3_6_223_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38644"},{"key":"e_1_3_6_224_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050563"},{"key":"e_1_3_6_225_2","doi-asserted-by":"publisher","DOI":"10.3390\/v11070596"},{"key":"e_1_3_6_226_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80058-6"},{"key":"e_1_3_6_227_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07402.x"},{"key":"e_1_3_6_228_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.027052-0"},{"key":"e_1_3_6_229_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-866"},{"key":"e_1_3_6_230_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuu004"},{"key":"e_1_3_6_231_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.24.13125-13135.2003"},{"key":"e_1_3_6_232_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01721-13"},{"key":"e_1_3_6_233_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00330-13"},{"key":"e_1_3_6_234_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.11.1742"},{"key":"e_1_3_6_235_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00074-08"},{"key":"e_1_3_6_236_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-00192-8"},{"key":"e_1_3_6_237_2","doi-asserted-by":"crossref","unstructured":"Tandon R et al. 2020 Effective inhibition of SARS-CoV-2 entry by heparin and Enoxaparin derivatives. bioRxiv 8:2020.06.08.140236. (doi:10.1101\/2020.06.08.140236)","DOI":"10.1101\/2020.06.08.140236"},{"key":"e_1_3_6_238_2","unstructured":"Liu L Chopra P Li X Wolfert MA Tompkins SM Boons GJ. 2020 SARS-CoV-2 spike protein binds heparan sulfate in a length- and sequence-dependent manner. bioRxiv 10:2020.05.10.087288. (doi:10.1101.2020.05.10.087288)"},{"key":"e_1_3_6_239_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.033"},{"key":"e_1_3_6_240_2","first-page":"eabd3072","article-title":"Neuropilin-1 is a host factor for SARS-CoV-2 infection","volume":"20","author":"Daly JL","year":"2020","unstructured":"Daly JL et al. 2020 Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science 20, eabd3072. (doi:10.1126\/science.abd3072)","journal-title":"Science"},{"key":"e_1_3_6_241_2","first-page":"eabd2985","article-title":"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity","volume":"20","author":"Cantuti-Castelvetri L","year":"2020","unstructured":"Cantuti-Castelvetri L et al. 2020 Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science 20, eabd2985. (doi:10.1126\/science.abd2985)","journal-title":"Science"},{"key":"e_1_3_6_242_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.4.1547"},{"key":"e_1_3_6_243_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26792"}],"container-title":["Open Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.200377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsob.200377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.200377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T09:10:46Z","timestamp":1669626646000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsob.200377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":242,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1098\/rsob.200377"],"URL":"https:\/\/doi.org\/10.1098\/rsob.200377","relation":{"has-review":[{"id-type":"doi","id":"10.1098\/RSOB.200377\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.200377\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.200377\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.200377\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.200377\/v1\/review1","asserted-by":"object"}]},"ISSN":["2046-2441"],"issn-type":[{"value":"2046-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"200377"}}