{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:09:02Z","timestamp":1781147342243,"version":"3.54.1"},"reference-count":90,"publisher":"The Royal Society","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT-388914"],"award-info":[{"award-number":["PJT-388914"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["RGPIN-2020-03925"],"award-info":[{"award-number":["RGPIN-2020-03925"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>\n                    The dorsal medial region of the developing mammalian telencephalon plays a central role in the patterning of the adjacent brain regions. This review describes the development of this specialized region of the vertebrate brain, called the\n                    <jats:italic>cortical hem<\/jats:italic>\n                    , and the formation of the various cells and structures it gives rise to, including the choroid plexus, Cajal\u2013Retzius cells and the hippocampus. We highlight the ontogenic processes that create these different forebrain derivatives from their shared embryonic origin and discuss the key signalling pathways and molecules that influence the patterning of the cortical hem. These include BMP, Wnt, FGF and Shh signalling pathways acting with Homeobox factors to carve the medial telencephalon into district progenitor regions, which in turn give rise to the choroid plexus, dentate gyrus and hippocampus. We then link the formation of the lateral ventricle choroid plexus with embryonic and postnatal neurogenesis in the hippocampus.\n                  <\/jats:p>","DOI":"10.1098\/rsob.210042","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T03:06:15Z","timestamp":1620183975000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Development of the mammalian cortical hem and its derivatives: the choroid plexus, Cajal\u2013Retzius cells and hippocampus"],"prefix":"10.1098","volume":"11","author":[{"given":"Samantha A.","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, and Brain Repair Centre, Life Science Research Institute, 1348 Summer Street, Halifax, Nova Scotia, Canada, B3H4R2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-4295","authenticated-orcid":true,"given":"Angelo","family":"Iulianella","sequence":"additional","affiliation":[{"name":"Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, and Brain Repair Centre, Life Science Research Institute, 1348 Summer Street, Halifax, Nova Scotia, Canada, B3H4R2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp031"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00504-9"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.106914"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.11.2203"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.12.2315"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01428"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.04.034"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02324"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.08.038"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151695"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs421"},{"key":"e_1_3_6_13_2","first-page":"117","article-title":"Estudios sobre la corteza cerebral humana I: corteza visual","volume":"4","author":"Ramon y Cajal S","year":"1899","unstructured":"Ramon y Cajal S. 1899 Estudios sobre la corteza cerebral humana I: corteza visual. 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