{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:08:32Z","timestamp":1790798912369,"version":"4.1.0"},"reference-count":53,"publisher":"The Royal Society","issue":"8","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":1499,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":1499,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":1499,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Urp1 and Urp2 are two neuropeptides of the urotensin II family identified in teleost fish and mainly expressed in cerebrospinal fluid (CSF)-contacting neurons. It has been recently proposed that Urp1 and Urp2 are required for correct axis formation and maintenance. Their action is thought to be mediated by the receptor Uts2r3, which is specifically expressed in dorsal somites. In support of this view, it has been demonstrated that the loss of uts2r3 results in severe scoliosis in adult zebrafish. In the present study, we report for the first time the occurrence of urp2, but not of urp1, in two tetrapod species of the Xenopus genus. In X. laevis, we show that urp2 mRNA-containing cells are CSF-contacting neurons. Furthermore, we identified utr4, the X. laevis counterparts of zebrafish uts2r3, and we demonstrate that, as in zebrafish, it is expressed in the dorsal somatic musculature. Finally, we reveal that, in X. laevis, the disruption of utr4 results in an abnormal curvature of the antero-posterior axis of the tadpoles. Taken together, our results suggest that the role of the Utr4 signalling pathway in the control of body straightness is an ancestral feature of bony vertebrates and not just a peculiarity of ray-finned fishes.<\/jats:p>","DOI":"10.1098\/rsob.210065","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T19:05:16Z","timestamp":1628622316000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod"],"prefix":"10.1098","volume":"11","author":[{"given":"Faredin","family":"Alejevski","sequence":"first","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Leemans","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Leistenschneider","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"de Flori","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Bougerol","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-7945","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Le M\u00e9vel","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Herrel","sequence":"additional","affiliation":[{"name":"Paris, France 2","department":["M\u00e9canismes adaptatifs et \u00e9volution UMR 7179 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Fini","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"P\u00e9zeron","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0719-0922","authenticated-orcid":false,"given":"Herv\u00e9","family":"Tostivint","sequence":"additional","affiliation":[{"name":"Paris, France 1","department":["Physiologie mol\u00e9culaire et adaptation UMR 7221 CNRS and Mus\u00e9um National d'Histoire Naturelle,"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"2026010716464258200_RSOB210065C1","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1073\/pnas.0510700103","article-title":"Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families","volume":"103","author":"Tostivint","year":"2006","journal-title":"Proc. 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