{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:30:42Z","timestamp":1784169042274,"version":"3.55.0"},"reference-count":73,"publisher":"The Royal Society","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"name":"European Research Council","award":["294678"],"award-info":[{"award-number":["294678"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    Naked mole-rats (NM-R;\n                    <jats:italic>Heterocephalus glaber<\/jats:italic>\n                    ) live in multi-generational colonies with a social hierarchy, and show low cancer incidence and long life-spans. Here we asked if an immune component might underlie such extreme physiology. The largest lymphoid organ is the spleen, which plays an essential role in responding to immunological insults and may participate in combating cancer and slowing ageing. We investigated the anatomy, molecular composition and function of the NM-R spleen using RNA-sequencing and histological analysis in healthy NM-Rs. Spleen size in healthy NM-Rs showed considerable inter-individual variability, with some animals displaying enlarged spleens. In all healthy NM-Rs, the spleen is a major site of adult haematopoiesis under normal physiological conditions. However, myeloid-to-lymphoid cell ratio is increased and splenic marginal zone showed markedly altered morphology when compared to other rodents. Healthy NM-Rs with enlarged spleens showed potentially better anti-microbial profiles and were much more likely to have a high rank within the colony. We propose that the anatomical plasticity of the spleen might be regulated by social interaction and gives immunological advantage to increase the lifespan of higher-ranked animals.\n                  <\/jats:p>","DOI":"10.1098\/rsob.210292","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T03:05:54Z","timestamp":1649214354000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Immune competence and spleen size scale with colony status in the naked mole-rat"],"prefix":"10.1098","volume":"12","author":[{"given":"Val\u00e9rie","family":"B\u00e9gay","sequence":"first","affiliation":[{"name":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association (MDC), Laboratory for Molecular Physiology of Somatic Sensation, Robert-R\u00f6ssle Stra\u00dfe 10, D-13125 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branko","family":"Cirovic","sequence":"additional","affiliation":[{"name":"Division of Cellular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Barker","sequence":"additional","affiliation":[{"name":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association (MDC), Laboratory for Molecular Physiology of Somatic Sensation, Robert-R\u00f6ssle Stra\u00dfe 10, D-13125 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klopfleisch","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Free University Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-558X","authenticated-orcid":true,"given":"Daniel W.","family":"Hart","sequence":"additional","affiliation":[{"name":"Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-2947","authenticated-orcid":true,"given":"Nigel C.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2890-6352","authenticated-orcid":true,"given":"Gary R.","family":"Lewin","sequence":"additional","affiliation":[{"name":"Max-Delbr\u00fcck-Center for Molecular Medicine in the Helmholtz Association (MDC), Laboratory for Molecular Physiology of Somatic Sensation, Robert-R\u00f6ssle Stra\u00dfe 10, D-13125 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0006-x"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.52.1.41"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31157"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812471543"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0300985816630796"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw047"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32833370cf"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00198-8"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3896"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2410-x"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7209555"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6588"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12791"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2007.00177.x"},{"key":"e_1_3_6_17_2","first-page":"83","article-title":"Extreme susceptibility of African naked mole rats (Heterocephalus glaber) to experimental infection with herpes simplex virus type 1","volume":"59","author":"Artwohl J","year":"2009","unstructured":"Artwohl J, Ball-Kell S, Valyi-Nagy T, Wilson SP, Lu Y, Park TJ. 2009 Extreme susceptibility of African naked mole rats (Heterocephalus glaber) to experimental infection with herpes simplex virus type 1. 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