{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:03:45Z","timestamp":1776953025722,"version":"3.51.4"},"reference-count":38,"publisher":"The Royal Society","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["31801174"],"award-info":[{"award-number":["31801174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Research Foundation of Chongqing Municipal Education","award":["KJQN201900446"],"award-info":[{"award-number":["KJQN201900446"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Cigarette smoke significantly induces oxidative stress, resulting in cardiovascular disease. NRF2, a well-known antioxidative stress response factor, is generally considered to play protective roles in cardiovascular dysfunction triggered by oxidative stress. Interestingly, recent studies reported adverse effects of NRF2 on the cardiovascular system. These unfavourable pathogenic effects of NRF2 need to be further investigated. Our work shows that cigarette smoke extract (CSE)-induced oxidative stress disturbs fibronectin (FN) assembly during angiogenesis. Furthermore, this effect largely depends on hyperactive NRF2-STAT3 signalling, which consequently promotes abnormal FN deposition. Consistently, disruption of this pathway by inhibiting NRF2 or STAT3 prevents CSE-induced FN disorganization and vasculature disruption in human umbilical vein endothelial cells or zebrafish. Taken together, these findings demonstrate the cardiovascular dysfunction caused by CSE from a novel perspective that NRF2-dependent signalling engages in FN disorganization.<\/jats:p>","DOI":"10.1098\/rsob.210310","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T19:05:17Z","timestamp":1650999917000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation"],"prefix":"10.1098","volume":"12","author":[{"given":"Jinjiang","family":"Xue","sequence":"first","affiliation":[{"name":"College of Basic Medicine, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"},{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenfeng","family":"Hua","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, 2 Fengyang Street, Zhengzhou 450001, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute of CNTC, 2 Fengyang Street, Zhengzhou 450001, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangfeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueru","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiguo","family":"Ran","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanghui","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxiong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-7118","authenticated-orcid":true,"given":"Liangjun","family":"Qiao","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Chongqing Medical University, 1 Yixueyuan Road, Chongqing 400016, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"175","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.8"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.11.028"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-014-9280-0"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7092151"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9030563"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-512749"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.02.026"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4683943"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.019"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101453"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124527"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041316"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06062"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00099-20"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2223-0"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201044"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6730315"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147600"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97459"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.03.042"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.4.1079"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100109-104020"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep04470"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.104885"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.10.035"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112050"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.8.3073"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks409"},{"key":"e_1_3_6_30_2","first-page":"D87","article-title":"JASPAR 2020: update of the open-access database of transcription factor binding profiles","volume":"48","author":"Fornes O","year":"2020","unstructured":"Fornes O et al. 2020 JASPAR 2020: update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 48, D87-D92. (doi:10.1093\/nar\/gkz1001)","journal-title":"Nucleic Acids Res."},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/diseases4040034"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/132931"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.007"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12747"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt150"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8309698"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.08.007"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.109617"},{"key":"e_1_3_6_39_2","doi-asserted-by":"crossref","unstructured":"Xue J et al. 2022 Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation. FigShare. (https:\/\/doi.org\/10.6084\/m9.figshare.c.5953708)","DOI":"10.1098\/rsob.210310"}],"container-title":["Open Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.210310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/full-xml\/10.1098\/rsob.210310","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/royalsocietypublishing.org\/doi\/pdf\/10.1098\/rsob.210310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T07:11:59Z","timestamp":1682665919000},"score":1,"resource":{"primary":{"URL":"https:\/\/royalsocietypublishing.org\/doi\/10.1098\/rsob.210310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1098\/rsob.210310"],"URL":"https:\/\/doi.org\/10.1098\/rsob.210310","relation":{"has-review":[{"id-type":"doi","id":"10.1098\/RSOB.210310\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.210310\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.210310\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.210310\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1098\/RSOB.210310\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2046-2441"],"issn-type":[{"value":"2046-2441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"2021-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"210310"}}