{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:16:16Z","timestamp":1786371376434,"version":"build-2736575974"},"reference-count":76,"publisher":"The Royal Society","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/royalsociety.org\/journals\/ethics-policies\/data-sharing-mining\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFD0900101"],"award-info":[{"award-number":["2018YFD0900101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shandong Technical System of Fish Industry","award":["SDAIT-12-03"],"award-info":[{"award-number":["SDAIT-12-03"]}]}],"content-domain":{"domain":["royalsocietypublishing.org"],"crossmark-restriction":true},"short-container-title":["Open Biol."],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n                    Body colour is an important economic trait for commercial fishes. Recently, a new colour morph displaying market-favoured yellow skin (termed as yellow-mutant, YM) of northern snakehead (\n                    <jats:italic>Channa argus<\/jats:italic>\n                    ) was discovered in China. We confirmed that YM snakehead is an albino with complete loss of melanin in the skin and eyes by histological and ultrastructural observations, and inherited as a recessive Mendelian trait. By applying genomic analysis approaches, in combination with gene knockdown and rescue experiments, we suggested a non-sense mutation in\n                    <jats:italic>slc45a2<\/jats:italic>\n                    (c.383G &gt; A) is the causation for the YM snakehead. Notably, significantly higher levels of key melanogenesis genes (\n                    <jats:italic>tyr<\/jats:italic>\n                    ,\n                    <jats:italic>tyrp1<\/jats:italic>\n                    ,\n                    <jats:italic>dct<\/jats:italic>\n                    and\n                    <jats:italic>pmel<\/jats:italic>\n                    ) and phospho-MITF protein were detected in YM snakehead than those in wild-type individuals, and the underlying mechanism was further investigated by comparative transcriptomic analysis. Results revealed that differential expressed genes involved in pathways like MAPK, WNT and calcium signalling were significantly induced in YM snakehead, which might account for the increased amount of melanogenesis elements, and presumably be stimulated by fibroblast-derived melanogenic factors in a paracrine manner. Our study clarified the genetic basis of colour variation in\n                    <jats:italic>C. argus<\/jats:italic>\n                    and provided the preliminary clue indicating the potential involvement of fibroblasts in pigmentation in fish.\n                  <\/jats:p>","DOI":"10.1098\/rsob.220235","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T03:05:35Z","timestamp":1676430335000},"update-policy":"https:\/\/doi.org\/10.1098\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (\n                    <i>Channa argus<\/i>\n                    )"],"prefix":"10.1098","volume":"13","author":[{"given":"Donglei","family":"Sun","sequence":"first","affiliation":[{"name":"Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao 266003, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Qi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao 266003, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haishen","family":"Wen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao 266003, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1950-0190","authenticated-orcid":true,"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao 266003, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao 266003, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexin","family":"Tao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao 266003, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao 266003, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-9404","authenticated-orcid":true,"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (KLMME), Fisheries College, Ocean University of China, Qingdao 266003, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"175","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/gix011"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(00)00246-4"},{"key":"e_1_3_7_4_2","volume-title":"China fishery statistical yearbook","author":"China's Ministry of Agriculture","year":"2022","unstructured":"China's Ministry of Agriculture. 2022 China fishery statistical yearbook. 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